DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC11

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1424	Identity:	445/1424 - (31%)
Similarity:	686/1424 - (48%)	Gaps:	212/1424 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RPK------NPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLD-SERVTNKFAELWE 67
            |||      .|...|..||..:..|:..|..:.|:..| ||.........| |::...:...|||
Human    75 RPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRL-DENTIPPLSVHDASDKNVQRLHRLWE 138

  Fly    68 DELKR---SNPSVVRMILRAYGK--IF-VPMGLAFSISETICKSLMP-LFLGGLVGYFATNQTDI 125
            :|:.|   ...||:.::||....  || ..:|:.|.|:..    |.| |.:..::.|......::
Human   139 EEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASV----LGPILIIPKILEYSEEQLGNV 199

  Fly   126 SENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQ---VSKSSSNDGLR 187
            .......:|:.:..|  |..::|........:...:.|.|:|...:.|::|   |...:|
Human   200 VHGVGLCFALFLSEC--VKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS----- 257

  Fly   188 GRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLM------YREIGISAVIGVSFMLSFIPL 246
            |.||:..:.|:......:|:      ||:..|....|:      |..||.:|.|.:...|...||
Human   258 GEAISFFTGDVNYLFEGVCY------GPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPL 316

  Fly   247 QAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAY 311
            ..:..:.|...:..|:|.:|.|:::.:|::..|::||||.|||.||::|.::|.||.|.:.....
Human   317 AVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGL 381

  Fly   312 IHAALGCTSMISPLSVFLALCSYVY--LGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEA 374
            :.:....|..|.| :|..|:...::  |...|||...:::.:..|:|..| |.|.|:::..:..:
Human   382 VQSLTSITLFIIP-TVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLS-VFFVPIAVKGLTNS 444

  Fly   375 LVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDY 439
            ..:..|.|.|.|.    |.|:......|
Human   445 KSAVMRFKKFFLQ----ESPVFYVQTLQ------------------------------------- 468

  Fly   440 DPEATKKCVVLKNVSASW-DTSDGHANCAIE--------------------------------DF 471
            ||   .|.:|.:..:.|| .|..|..|.|:|                                ..
Human   469 DP---SKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKI 530

  Fly   472 STDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFV 536
            :..:....:..|.|..|:||||.|:.:|.|:.:.:|...|.|.::|..|::|:..|.||:||:..
Human   531 NLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMG 595

  Fly   537 EDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDP 601
            ..|::.||.:|:..|.|.||:||||.||:|.:||||::||||||.|:|||||||....|||||||
Human   596 GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDP 660

  Fly   602 LSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL-QRSRQ 665
            |||||.|||||||:.||:..|..|..:|||||:|||.....::|:.:|||...|::.|| |:..:
Human   661 LSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGK 725

  Fly   666 FQFLEQTQHDESGID----------THSVSSYLSRSDSEKSM--------EHQHNQLLRPDEHVE 712
            :..|.|..|.|:..|          ...|.|....:..|:|:        |||..|
Human   726 YAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAGNVPEHQLTQ--------- 781

  Fly   713 DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWV-IWEEQIAVN 776
               :|:...||:...||..||:|... :::..:|..||...:.||...::   |: .|.||   .
Human   782 ---EEEMEEGSLSWRVYHHYIQAAGG-YMVSCIIFFFVVLIVFLTIFSFW---WLSYWLEQ---G 836

  Fly   777 RTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYL---IRT 838
            ..|....|::.|:|:  |...|.:|.::                 ||..:.|...::.:   :.:
Human   837 SGTNSSRESNGTMAD--LGNIADNPQLS-----------------FYQLVYGLNALLLICVGVCS 882

  Fly   839 FGFF-KMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFI 902
            .|.| |:..:.|..||::||..:.|..|.||:|...||:||.|:.|:..:|..||......|...
Human   883 SGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLS 947

  Fly   903 IDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLT 967
            :.|..|::||::.:.::|:..|||.||..:...::.......||||:.||||:||....:.|||:
Human   948 LMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLS 1012

  Fly   968 TIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVT-----------FS 1021
            :|...........:|....:...:...||||.||..||..:::..:...||.           :|
Human  1013 SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYS 1077

  Fly  1022 FLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQ-PSEALLETPEK 1085
            |.::.       |.:.:..:::.....:.|:    |.|.|.|:|||:|:|.:. .|||.|.....
Human  1078 FKVMA-------VNIVLQLASSFQATARIGL----ETEAQFTAVERILQYMKMCVSEAPLHMEGT 1131

  Fly  1086 FKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA- 1149
            ..|:. ||..|.|.|.::.::|......||..:|.||...|.:|||||||:||||:..::|||.
Human  1132 SCPQG-WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVE 1195

  Fly  1150 CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRS 1214
            ...|.|.||.|||..|||.||||::|:|||||||.|||:|:||||.|..:|:::|.||....|..
Human  1196 PMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTK 1260

  Fly  1215 YVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSK 1279
            .:|.....|:..:.:.|.|||||:|||:|:|||:||::||:::|||||::|.|||.|||:|||..
Human  1261 AISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREA 1325

  Fly  1280 FAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATS 1338
            |..||||.||||:.||::.|.:|||..|:|.|...|..|.::.|.....|:   ..|||
Human  1326 FQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALM---ATATS 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	443/1422 (31%)
		ABC_membrane	94..360	CDD:294371	66/277 (24%)
		ABCC_MRP_domain1	448..650	CDD:213217	94/234 (40%)
		ABC_membrane	821..1046	CDD:294371	64/239 (27%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	112/219 (51%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	438/1401 (31%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		0/18 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650