Protein Alignment rdog and YOR1

DIOPT Version :9

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_011797.3
• Gene: YOR1 / 853198
• SGDID: S000003513
• Length: 1477
• Species: Saccharomyces cerevisiae
• Alignment Length: 1435
• Identity: 420/1435 - (29%)
• Similarity: 676/1435 - (47%)
• Gaps: 178/1435 - (12%)

  Fly     6 RKVVRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQ--HRKTLDS------------- 55
            ||:.    |....|..|...|||:..:.:.|.:..:...:|::  .|.::::
Yeast   105 RKIY----PLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYF 165

  Fly    56 ERVTNKF----AELWEDEL----KRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLG 112
            |:...|:    .|..|:|:    |....:|:|.:|..:.|.:. |.:.|:|.........|:...
Yeast   166 EKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYF-MSIVFAILANCTSGFNPMITK 229

  Fly   113 GLVGYFATNQT--DISENTAYLYAMGIVICMLVPVITFHPFIFYIFQV-GTKLRLALSGLIYRKV 174
            .|:.:......  .:..|....||:|..:.|.|..:||:.| |:..|: |.:.:..|:....:|:
Yeast   230 RLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHF-FHTSQLTGVQAKSILTKAAMKKM 293

  Fly   175 LQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGF---------LMYREIG 230
            ...|..:.:....|:..:.::.||.|.:.||.|         :..|.||         |:...:|
Yeast   294 FNASNYARHCFPNGKVTSFVTTDLARIEFALSF---------QPFLAGFPAILAICIVLLIVNLG 349

  Fly   231 ISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVI 295
            ..|::|:........:..:|.|....:|......||.||.:|.|::..|::||.|.||.::.:.|
Yeast   350 PIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNI 414

  Fly   296 AEVRLKEVKAIR----GTAYIHAALGCTSMISPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNML 356
            .::|.||:..:|    ...::.|.......|:.|..|||:  |...........::...|.|.:|
Yeast   415 QDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAM--YKVNKGGRQPGNIFASLSLFQVL 477

  Fly   357 NDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISK--------K 413
            :..|. |.|::|....:.::...|.:. ||:..:.:....:|.....|.:.:...|        :
Yeast   478 SLQMF-FLPIAIGTGIDMIIGLGRLQS-LLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEWE 540

  Fly   414 DKQKN---VELNGSLLSNGQVHHNRLRDY--DPEA-TKKCVVLKNVSASWDTSDGHANCA---IE 469
            |.:.|   .|..|.....|:.:..:.:|.  .|.| |.|...|.|:....|..:.....:   .:
Yeast   541 DYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFK 605

  Fly   470 DFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIV 534
            |.:.|||......:.||:|.||||.||.:.|.:....|:..|:|.:..... .|:...::||||:
Yeast   606 DLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNII 669

  Fly   535 FVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLD 599
            |...:|:.:|.:||:||.|:.|:::||.||:|.:||||::||||||||::|||:||:|.||||.|
Yeast   670 FGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFD 734

  Fly   600 DPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSR 664
            |.|||||:.|||||.|.|:...|:||.|||.|||:..:.....::::|:...:..|:..||:...
Yeast   735 DVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKARN 799

  Fly   665 Q-----FQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEH---------QHNQLLRPDEHVED-- 713
            |     .||..|....|.......|:..|.:...|..::.         :.:|.....:.|.|
Yeast   800 QTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGH 864

  Fly   714 -VNQEQQTVGSIKMHVYASYIKALDSTFLLG----IVISLFVCARIMLTGVDYFLSRWV-IWEEQ 772
             .::|::.|.||.:.:|..||||     .:|    |.:.|:....:..|....|.|.|: .|.|.
Yeast   865 TSSKEERAVNSISLKIYREYIKA-----AVGKWGFIALPLYAILVVGTTFCSLFSSVWLSYWTEN 924

  Fly   773 IAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIR 837
            ...||..:                                         ||..:....:....|.
Yeast   925 KFKNRPPS-----------------------------------------FYMGLYSFFVFAAFIF 948

  Fly   838 TFGFF----KMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDC 898
            ..|.|    .|.:..|..|:.|..:.|....|.:.:|...|||||||:||..::|.:|..:|...
Yeast   949 MNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLM 1013

  Fly   899 LAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTF 963
            .:...::.||.::..:...|..|....:.||..:|...|.::.|.:||||::.||.|::..|:..
Yeast  1014 TSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVL 1078

  Fly   964 QGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDE 1028
            .|:.||:|.::|.....:.....|....|.:|.:...|...::.|::.|.:...:|...:.....
Yeast  1079 GGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFP 1143

  Fly  1029 FDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEY-TEQPSEALLETPEKFKPKSEW 1092
            ..:..||:.:.:...:.|:....:|...:.||.|.|.||::.| ||.|.||....||...|:| |
Yeast  1144 ISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPES-W 1207

  Fly  1093 PSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNE---GM 1154
            ||.|.|.|.|....|.|....|||:||..|:..|||||.||||||||:|:.:::||  ||   |.
Yeast  1208 PSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRL--NELTAGK 1270

  Fly  1155 IRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKA-----------LG 1208
            |.||:|||..:||.|||.:::|||||||||.||:|.||||.:||:|:|:|.|           |.
Yeast  1271 ILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLP 1335

  Fly  1209 DVELRSYVSTLIGGLNCRMY---------DGGSNFSVGQRQLVCLARAILRHNKILIMDEATANV 1264
            :|:|:....   .|.:.:|:         :.|||||:|:|||:.|.||::|.:||||:||||::|
Yeast  1336 EVKLQKPDE---NGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSV 1397

  Fly  1265 DPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQL 1329
            |.|||..||..|..:|..||:|.|||||.|:::.||:||::.|||.|...|:.|..:.....|.:
Yeast  1398 DYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSM 1462

  Fly  1330 VDNTG 1334
            ...:|
Yeast  1463 CSRSG 1467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	418/1429 (29%)
		ABC_membrane	94..360	CDD:294371	63/281 (22%)
		ABCC_MRP_domain1	448..650	CDD:213217	85/204 (42%)
		ABC_membrane	821..1046	CDD:294371	55/228 (24%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	116/241 (48%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	420/1435 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I2258
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.660