DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and YCF1

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_010419.3	Gene:	YCF1 / 851713	SGDID:	S000002542	Length:	1515	Species:	Saccharomyces cerevisiae

Alignment Length:	1393	Identity:	458/1393 - (32%)
Similarity:	722/1393 - (51%)	Gaps:	179/1393 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TRRKVVRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWED 68
            ||||    .||:..||.||:.:|.||..|.|.|.:..|.:.:||:..:...||.::.|..:.||:
Yeast   205 TRRK----PNPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWEN 265

  Fly    69 ELK-RSNPSVVRMILRAYGKIFVPMGLAFSISETIC---KSLMPLFLGGLVGYFATNQTDIS--- 126
            ||| :||||:...|.|.:|...:......:|.:.:.   ..|:.:.:..:..|.:..|.|.|
Yeast   266 ELKQKSNPSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQ 330

  Fly   127 --ENT---------AYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKS 180
              ||.         .:|.|..:.:.........|.:...:|..|..::.||:.|||:|.|.:|..
Yeast   331 GFENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNE 395

  Fly   181 SSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIP 245
            :|.....|..:|::|.|:.:......:|:..|.||.:.|:..:.:|:.:|.|..:||..::..:|
Yeast   396 ASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMP 460

  Fly   246 LQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVR-LKEVKAIRGT 309
            |.::..:.....::...:..|.|.::::||:..|:.:|:|||||.:...:.||| .||:|.:
Yeast   461 LNSFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNL--- 522

  Fly   310 AYIHAALGC----TSMISPLSVFLALCS----YVYLGD-PLTAQKVYTVSSYFNMLNDSMVTFWP 365
                ..|||    ||....:..||..|.    :||..| .||...|:...:.||:|:..::.. |
Yeast   523 ----TKLGCYMAVTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPLMII-P 582

  Fly   366 MSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQ 430
            |.:....||.||..|...|.             .|::...:  .:.:..|.||:   |.:..|..
Yeast   583 MVLNSFIEASVSIGRLFTFF-------------TNEELQPD--SVQRLPKVKNI---GDVAINIG 629

  Fly   431 VHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFL 495
            .....|....||..   |.|||:  ::....|:..|                :||.||:||::.|
Yeast   630 DDATFLWQRKPEYK---VALKNI--NFQAKKGNLTC----------------IVGKVGSGKTALL 673

  Fly   496 NVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELL 560
            :.:||::...||.|.|||.::|.||..|:..||:::||:|...|:...|:|.:|.|.|..|:.:|
Yeast   674 SCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAIL 738

  Fly   561 PRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCI--RDFLS 623
            ..||.|:|||:|:|||||||||:|||||||.:||.|||||||:|||.||.:|:.:..:  ...|.
Yeast   739 MDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLH 803

  Fly   624 NKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQ--------------------RSRQFQF 668
            .|.::|.|::|..|...:.:.|:.:|:|..||:|.|:.                    :|.:|..
Yeast   804 TKTKVLATNKVSALSIADSIALLDNGEITQQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFGD 868

  Fly   669 LEQTQHDESGIDTHSVSSYLSR--------SDSEKSMEHQHNQLLRPDEHVEDVN---QEQQTVG 722
            ..::...||.|........|.:        ||: .|:....:..|...:..:|.|   :|.:..|
Yeast   869 SSESSVRESSIPVEGELEQLQKLNDLDFGNSDA-ISLRRASDATLGSIDFGDDENIAKREHREQG 932

  Fly   723 SIKMHVYASYIKALD----STFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLN 783
            .:|.::|..|.||.:    ..|:|.||||:|    :.:.| :.:|..|                :
Yeast   933 KVKWNIYLEYAKACNPKSVCVFILFIVISMF----LSVMG-NVWLKHW----------------S 976

  Fly   784 ETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMC-LR 847
            |.::..        .::|..|..||            :::|..:|:.|.. ||:|...:..| :.
Yeast   977 EVNSRY--------GSNPNAARYLA------------IYFALGIGSALAT-LIQTIVLWVFCTIH 1020

  Fly   848 ISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIV 912
            .|.:||:.:...:.||.|.||.|...||||||||.||..||..|..|........:.|:..:.::
Yeast  1021 ASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVI 1085

  Fly   913 AIANYW----LLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQ 973
            . |..|    ::||.::..:   ..:..|:.|||.::||:||:|||::|...:|..||.|:|...
Yeast  1086 C-ATTWQFIFIIIPLSVFYI---YYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYS 1146

  Fly   974 AQSALEQEFHEYQ---NTNTSAWFLFLSCTRAFALWSDVL-CIVYMTAVTFS-FLLLKDEFDSGD 1033
            .|....   |..|   :.|.||::..::..|..|...::: .|:.:.|.|.| |.|.:....:|.
Yeast  1147 QQKRFS---HINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGM 1208

  Fly  1034 VGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRI 1098
            |||::.::..:|....|.:|.|.|:|..:.||||:.||.:..|||.| ..|..:|..||||:|.|
Yeast  1209 VGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPL-IVEGHRPPKEWPSQGDI 1272

  Fly  1099 EFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDI 1162
            :|.|:..||.|:...|||.:|..|:|.||:||||||||||||:..::|| :..:||.|.||::.|
Yeast  1273 KFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAI 1337

  Fly  1163 EHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIG-GLNCR 1226
            ..|||:|||.::||||||..:|.||:|.|:||:::.:||.:|:||....|:.:|.::.. ||:.:
Yeast  1338 NEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQ 1402

  Fly  1227 MYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHR 1291
            :.:||.|.|||||||:|||||:|..:|||::|||||.||.||||::|:|||:.|...|:||||||
Yeast  1403 LTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHR 1467

  Fly  1292 LHTVMDSDRVLVMDAGEVRELGHPYELL 1319
            |:|:|||||::|:|.|:|.|...|.:||
Yeast  1468 LNTIMDSDRIIVLDNGKVAEFDSPGQLL 1495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	454/1385 (33%)
		ABC_membrane	94..360	CDD:294371	72/292 (25%)
		ABCC_MRP_domain1	448..650	CDD:213217	83/203 (41%)
		ABC_membrane	821..1046	CDD:294371	70/234 (30%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	117/220 (53%)
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	458/1393 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720