DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and YBT1

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_013052.1	Gene:	YBT1 / 850678	SGDID:	S000003971	Length:	1661	Species:	Saccharomyces cerevisiae

Alignment Length:	1473	Identity:	431/1473 - (29%)
Similarity:	707/1473 - (47%)	Gaps:	267/1473 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQW----SFWW--------MRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELW 66
            |.|....|..|    ||.|        ::|::  ||.  :.|...:          |..||....
Yeast   282 PVTSIAGFICWAWLDSFVWKAHKVSIKVKDIW--GLM--MQDYSFF----------VVKKFRYFV 332

  Fly    67 EDELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFAT----------- 120
            :.::||.             :|| .:.|.|..|..:.......|||.::.:..|
Yeast   333 DHKVKRK-------------RIF-SLNLFFFFSNYLVLQCFWAFLGSVLSFIPTVLLKRILEYVE 383

  Fly   121 NQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVL---------- 175
            :|:....|.|:.|...:.:..::..|.....:|:..:|..:::..:...||.|.|
Yeast   384 DQSSAPSNLAWFYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTK 448

  Fly   176 ------------------QVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIG 222
                              :.|.||:|   .|..||:::.|..:......:||...:..:.:::..
Yeast   449 PSNEDPQEINDQKSINGDEESTSSAN---LGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVAL 510

  Fly   223 FLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAW 287
            .|:||.:|.:|::||..:::.:||....||.....::.....||.|::.:||..|.|::||.::|
Yeast   511 ALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSW 575

  Fly   288 EKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLA-LCSYVYL-GDPLTAQKVYTVS 350
            |::|.:.|..:|..|:..:...:.:.:.......::|..|..| ...|:|: |:.||....:|..
Yeast   576 EENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTAL 640

  Fly   351 SYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDK 415
            |.|.:|.|.:.....| ::|:.::.||..|.:|||.:.|                     :||..
Yeast   641 SLFTLLRDPLDRLSDM-LSFVVQSKVSLDRVQDFLNEND---------------------TKKYD 683

  Fly   416 QKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTL 480
            |..::.||          ||.            ..:|.:.|||..  :.:..::|.:.:.|...|
Yeast   684 QLTIDPNG----------NRF------------AFENSTISWDKD--NQDFKLKDLNIEFKTGKL 724

  Fly   481 AAVVGPVGAGKSSFLNVLLGEVGIDKGEAMV----------------HGKISYASQESWVFEGTI 529
            ..|:||.|:||:|.|..||||:.:..|:.:|                ...|:|.||.:|:...|:
Yeast   725 NVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTV 789

  Fly   530 RDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKAD 594
            ::||:|...:||.|||.||:.|||:||.|:|..||||.:||:|::||||||.|||||||:|..|.
Yeast   790 KNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNAR 854

  Fly   595 IYLLDDPLSAVDTHVGKHIFDRCIR-DFLSNKIRILVTHQVQY-LFDVEHLLLMGSGKIMAQGSY 657
            ..||||.|||||:|....|:|.||. ..:.::..|||:|.:.. |.:.|.::|:..|::..||..
Yeast   855 HVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDP 919

  Fly   658 QELQRSRQFQFLEQTQHDESGIDTHSVSSYLSRSDS-------------------EKSMEHQHN- 702
            .::.:...|           |.|....||.|||::|                   |:.:...:|
Yeast   920 IDMLQKGLF-----------GEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNS 973

  Fly   703 ---------QLLRPD-EHVED---VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARI 754
                     :.||.: |..||   :.:|.:..|.:.:.||..|:|......::..:.|||:.|::
Yeast   974 SHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQL 1038

  Fly   755 MLTGVDYFLSRW--------VIWEEQIAV----NRTTTLLN---ETDTTIA---NDTLPINATDP 801
            :..|..:::..|        :|...|.|:    .:.:.|::   .:..::|   |.....::|..
Yeast  1039 LYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMY 1103

  Fly   802 YIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMY 866
            |:...|           ::.|...:|||.      :|...|...:..|..:.:.:...:..:.:.
Yeast  1104 YLVLYL-----------IIGFAQALLGAG------KTILNFVAGINASRKIFNMILNKVLHSKIR 1151

  Fly   867 FFNTNSSGRILNRFSKDIRTVDTDLP-------HTLLDCLAFIIDVSGVVIIVAIANYWLLIPAA 924
            ||:...:|||:|||||||..:|.:|.       ::|::||      |.|::|..|...:|.: |.
Yeast  1152 FFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECL------STVILITFITPQFLSV-AI 1209

  Fly   925 IIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQE-FHEYQNT 988
            ::.::...:.|.|:..||.:||.|||||||::...::|..|:|||||...:....|| .|:....
Yeast  1210 VVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDEN 1274

  Fly   989 NTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMR 1053
            |...::|::: .|..|...|::..:.:.......|...:..|||..|:::.::.:.|....|.:|
Yeast  1275 NKPFFYLWVA-NRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVR 1338

  Fly  1054 QTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDL 1118
            ..:|:|..|.|||||.||.|...|...|  .|..|..:||..|:||..:..|||:|....|:|::
Yeast  1339 LYSEVEMNMNSVERVKEYMEIEQEPYNE--HKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNV 1401

  Fly  1119 NFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPV 1182
            :|:::.:.|||||||||||||:||.::|| |....|.|:||::||..:.|..||..::||||||.
Yeast  1402 SFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPT 1466

  Fly  1183 LFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGG---------------------LNCR 1226
            |||||::.||||.||.||.::::||..|.|.|......|.                     |:..
Yeast  1467 LFSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSE 1531

  Fly  1227 MYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHR 1291
            :.:||||.|.|||||:||||::||..||:::|||||::|..:|..||:|||.:|...|:||||||
Yeast  1532 ISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHR 1596

  Fly  1292 LHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTG 1334
            |.:|:|.|::||||||||:|..|||.||.........:.:::|
Yeast  1597 LRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCEHSG 1639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	431/1473 (29%)
		ABC_membrane	94..360	CDD:294371	67/306 (22%)
		ABCC_MRP_domain1	448..650	CDD:213217	87/219 (40%)
		ABC_membrane	821..1046	CDD:294371	63/232 (27%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	114/240 (48%)
YBT1	NP_013052.1	MRP_assoc_pro	<353..1639	CDD:188098	409/1372 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640