DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and BPT1

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_013086.1	Gene:	BPT1 / 850645	SGDID:	S000003938	Length:	1559	Species:	Saccharomyces cerevisiae

Alignment Length:	1445	Identity:	451/1445 - (31%)
Similarity:	702/1445 - (48%)	Gaps:	233/1445 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSER------------VTNKFAELWE 67
            :...:..|..:|.||..|.          .|.|:::|..|..:            ::.:|...||
Yeast   216 YPPVHVLSYITFIWMNKLI----------VETYRNKKIKDPNQLPLPPVDLNIKSISKEFKANWE 270

  Fly    68 DELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMP----LFLGGLVGYFATNQTDISE- 127
            .|...:..|:.|.|.:::|:. :.:.:.:..:..:...:.|    :|:.||      |....|:
Yeast   271 LEKWLNRNSLWRAIWKSFGRT-ISVAMLYETTSDLLSVVQPQFLRIFIDGL------NPETSSKY 328

  Fly   128 ---NTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGR 189
               |..:: |:.:.:..:|.|...:.|...||:.|..:|.:|:.|:|:|.|:::.:..|:...|.
Yeast   329 PPLNGVFI-ALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGD 392

  Fly   190 AINILSNDLGR----FDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWA 250
            .:|::|.|:.|    |:.|...:    ..|::.|::...:|..:|.:.:.|:..|...:|:.|:.
Yeast   393 ILNLMSVDVLRIQRFFENAQTII----GAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFL 453

  Fly   251 AKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVR----LKEVKAIRGTA- 310
            ::|.....:...:..|||:|.:.|::..|:.||:||||:.....:..||    ||..:.|...:
Yeast   454 SRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSN 518

  Fly   311 YIHAALGCTSMISPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEAL 375
            .|:.|..|..::...|.| .|.| ::...||:...|:...|.||:||.::.:. |..|..|.|..
Yeast   519 LIYFAWNCVPLMVTCSTF-GLFS-LFSDSPLSPAIVFPSLSLFNILNSAIYSV-PSMINTIIETS 580

  Fly   376 VSAKRCKDFLL--------------DGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLL 426
            ||.:|.|.|||              ..|:..:|. :|.|..|...|.|              .:|
Yeast   581 VSMERLKSFLLSDEIDDSFIERIDPSADERALPA-IEMNNITFLWKSK--------------EVL 630

  Fly   427 SNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGK 491
            ::.|...|...|.:.......:.|||               |:.|  :.|...|..|||.|||||
Yeast   631 TSSQSGDNLRTDEESIIGSSQIALKN---------------IDHF--EAKRGDLVCVVGRVGAGK 678

  Fly   492 SSFLNVLLGEVGIDKGE--------AMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVV 548
            |:||..:||::....|.        .:....::|.|||||:...::|:||:|...:::..|...:
Yeast   679 STFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTI 743

  Fly   549 KVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHI 613
            |.|.|..|:::||.||.|:|||:|:|||||||||:|||||||.:||||||||.|||||..|.|:|
Yeast   744 KACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNI 808

  Fly   614 FDRCI---RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR-----SRQFQFLE 670
            .:..:   ...|.||..||.|:.|..|...:.:..:.:|:|:.||:|:::..     |:..:.||
Yeast   809 IEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLE 873

  Fly   671 --------------QTQH-DESGID-------THSVSSYLSRSDSEKSMEHQHNQ-----LLRPD 708
                          ||:| .||.:|       |.|.:.....::||..:...:::     .|||.
Yeast   874 EFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPR 938

  Fly   709 EHV----EDVNQ-----EQQTVGSIKMHVYASYIKALDSTFLLGIVI-SLF-VCARIMLTGVDYF 762
            ..|    :.|.:     |:..||.:|..:|.:||||..   :||:|: .|| :..|:.....:::
Yeast   939 PFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKACG---VLGVVLFFLFMILTRVFDLAENFW 1000

  Fly   763 LSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATIL 827
            |..|....|:...|....:.....:.|.                :||.....:|..::|.|.:|.
Yeast  1001 LKYWSESNEKNGSNERVWMFVGVYSLIG----------------VASAAFNNLRSIMMLLYCSIR 1049

  Fly   828 GATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLP 892
            |                    |..||:.:.:.:.|:.|.||.|...|||:||||.|:..||::|.
Yeast  1050 G--------------------SKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQ 1094

  Fly   893 HTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFS 957
            :........|:.....||:|.....|.|:....:.||....:..|:..||.:|||.|||.||:.|
Yeast  1095 YIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMS 1159

  Fly   958 LTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV------LCIVYMT 1016
            |.:::..|.:.|.|...........:|....|....|.|.|..|    |..|      ..||..|
Yeast  1160 LMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNR----WLSVRLQTIGATIVLAT 1220

  Fly  1017 AV-TFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALL 1080
            |: ..:.:..|.:..||.|||.:.:|..:||...|.:|.|..:|..:.||||::||.|.|.||..
Yeast  1221 AILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQS 1285

  Fly  1081 ETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSI 1145
            ..||| :|...|||||.|||.|:..:|.....|||.::|..|||.||:|||||||||||::..::
Yeast  1286 INPEK-RPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLAL 1349

  Fly  1146 FR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGD 1209
            || |...||.|.||.:||..|||.||||.::|||||...|.||::.||||.:..|::|:.:|:..
Yeast  1350 FRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQ 1414

  Fly  1210 VELRSYVSTLI-------------GGLN----CRMYDGGSNFSVGQRQLVCLARAILRHNKILIM 1257
            ..|:.::..::             |.:|    .::.:.|||.|||||||:|||||:|..:|||::
Yeast  1415 AHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVL 1479

  Fly  1258 DEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQ-- 1320
            |||||:||.||||:||.|||.:|...|:||||||:.||:|||:::|:|.|.|||...|.:||.
Yeast  1480 DEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDK 1544

  Fly  1321 --------RTGGYLR 1327
                    ..||||:
Yeast  1545 TSIFYSLCEKGGYLK 1559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	451/1445 (31%)
		ABC_membrane	94..360	CDD:294371	69/282 (24%)
		ABCC_MRP_domain1	448..650	CDD:213217	85/212 (40%)
		ABC_membrane	821..1046	CDD:294371	66/231 (29%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	115/236 (49%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	447/1434 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650