DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC12

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1376	Identity:	419/1376 - (30%)
Similarity:	694/1376 - (50%)	Gaps:	175/1376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPSVV 78
            |...|:.||:..|.|:..|.:.|.:.|:|:::::|..|...:|.:..:|...|.:|.:|..|.::
plant   228 PERHASIFSRIYFGWITPLMQLGYRKPITEKDVWQLDKWDQTETLIKRFQRCWTEESRRPKPWLL 292

  Fly    79 RMILRAYGKIFVPMGL--AFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICM 141
            |.:..:.|..|...|:  ...|...:.:.:.|:.|..|:   .:.|........|:||..|.:.:
plant   293 RALNNSLGGRFWLAGIFKVTRIGNDLSQFVGPVILSHLL---RSMQEGDPAWVGYVYAFIIFVGV 354

  Fly   142 LVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALC 206
            .:.|:....:...:::||.:||..|...|:.|.|:::..:..:...|:..|:::.|.........
plant   355 TLGVLCEAQYFQNVWRVGFRLRSTLVAAIFHKSLRLTHEARKNFASGKVTNMITTDANALQQISQ 419

  Fly   207 FLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAER---TDMR 268
            .||..|..|...|:...|:|:::|::::.|...:...||||.....|   .|::|.|.   ||.|
plant   420 QLHGLWSAPFRIIVSMILLYQQLGVASLFGSLILFLLIPLQTLIISK---MRKLTKEGLQWTDKR 481

  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCS 333
            |.:.|||:..:..:|.|||||||...|..:|.:|:...| .|.:.:|.. :.:::.:.|.:.:.|
plant   482 VGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFR-KAQLLSAFN-SFILNSIPVVVTVVS 544

  Fly   334 ---YVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPI 395
               :|.||..||..:.:|..|.|.:|...: ...|..::.:..|.||.:|.::.||..::.
plant   545 FGVFVLLGGDLTPARAFTSLSLFAVLRFPL-NMLPNLLSQVVNANVSLQRIEELLLSEERI---- 604

  Fly   396 NLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTS 460
             |..|.........||                                      :||...|||:.
plant   605 -LAQNPPLQPGTPAIS--------------------------------------IKNGYFSWDSK 630

  Fly   461 DGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVG-IDKGEAMVHGKISYASQESWV 524
            .  ....:.|.:.:|...||.|:||..|.||:|.::.:|||:. .:....::.|.::|..|.||:
plant   631 T--TKPTLSDINLEIPVGTLVAIVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWI 693

  Fly   525 FEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAV 589
            |..|:|:||:|..|:...||.:.:....|:.|::|||..|||.:|||||::|||||.|||:||||
plant   694 FNATVRENILFGSDFESERYWRAIDATALQHDLDLLPGRDLTEIGERGVNISGGQKQRVSMARAV 758

  Fly   590 YRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQ 654
            |..:|:|:.||||||:|.||...:||.|::|.|..|.|:|||:|:.:|..::.::|:..|.|..:
plant   759 YSNSDVYIFDDPLSALDAHVAHQVFDSCMKDELRGKTRVLVTNQLHFLPLMDKIILVSEGMIKEE 823

  Fly   655 GSYQELQRSRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLR--PDEHVED---- 713
            |::.||.:              |||....:.....:.|:.:.:......:|:  |...|:.
plant   824 GTFVELSK--------------SGILFKKLMENAGKMDATQEVNTNDENILKLGPTVTVDVSERN 874

  Fly   714 --------------VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLS 764
                          :.||::..|.|..:|...|.:|:...:::.|:::.::...::......:||
plant   875 LGSTKQGKRRRSVLIKQEERETGIISWNVLMRYKEAVGGLWVVMILLACYLATEVLRVSSSTWLS 939

  Fly   765 RWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGA 829
            .|                  ||.:.:.:..|                  |.   .::.||.:...
plant   940 IW------------------TDQSTSKNYSP------------------GF---YIVVYALLGFG 965

  Fly   830 TLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVD---TDL 891
            .:.|....:|......|..:..|||.:...|.||.|.||:||.:||::|||||||..:|   .:|
plant   966 QVAVTFTNSFWLITSSLHAARRLHDAMLSSILRAPMLFFHTNPTGRVINRFSKDIGDIDRNVANL 1030

  Fly   892 PHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYV-NTSRSVKRLESISRSPV 955
            .:..::.|..::....::..|:..:.|.::|.    :||....|||. :|||.|:||:|::|||:
plant  1031 MNMFMNQLWQLLSTFALIGTVSTISLWAIMPL----LILFYAAYLYYQSTSREVRRLDSVTRSPI 1091

  Fly   956 FSLTNQTFQGLTTIRALQAQSALEQ----------EFHEYQNTNTSAWF-LFLSCTRAFALWSDV 1009
            ::...:...||::|||.:|...:.:          .| ...||:::.|. :.|.......:|
plant  1092 YAQFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRF-TLANTSSNRWLTIRLETLGGVMIW--- 1152

  Fly  1010 LCIVYMTAVTFSFLLLKDEFDSGD------VGLAILHSTTMTGMCQWGMRQTAELENQMTSVERV 1068
                    :|.:|.:|::...:..      :||.:.::..:|.:....:||.:..||.:.|||||
plant  1153 --------LTATFAVLQNGNTNNQAGFASTMGLLLSYTLNITSLLSGVLRQASRAENSLNSVERV 1209

  Fly  1069 LEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGR 1133
            ..|.:.|||| .:..|..:|...|||.|.|:|.:..|||.|...|||..|.|.:.|.||:|:|||
plant  1210 GNYIDLPSEA-TDIIENNRPVCGWPSGGSIKFEDVHLRYRPGLPPVLHGLTFFVSPSEKVGVVGR 1273

  Fly  1134 TGAGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDE 1197
            |||||||::.::||:. ..:|.|.|||.|:...||.|:|..:|||||.|||||||:|:|:||..|
plant  1274 TGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVLSIIPQSPVLFSGTVRFNIDPFSE 1338

  Fly  1198 RSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATA 1262
            .:|..:|:||....::..:|....||:..:.:||.|||||||||:.||||:||.:|||::|||||
plant  1339 HNDAGLWEALHRAHIKDVISRNPFGLDAEVCEGGENFSVGQRQLLSLARALLRRSKILVLDEATA 1403

  Fly  1263 NVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLR 1327
            :||..||.|||:|||.:|..||:|.|||||:|::|.|::||:.:|:|.|...|.|||.|......
plant  1404 SVDVRTDSLIQRTIREEFKSCTMLVIAHRLNTIIDCDKILVLSSGQVLEYDSPQELLSRDTSAFF 1468

  Fly  1328 QLVDNTGAATS 1338
            ::|.:||.|.:
plant  1469 RMVHSTGPANA 1479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	419/1376 (30%)
		ABC_membrane	94..360	CDD:294371	70/273 (26%)
		ABCC_MRP_domain1	448..650	CDD:213217	83/202 (41%)
		ABC_membrane	821..1046	CDD:294371	63/245 (26%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	114/219 (52%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720