DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC10

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1351	Identity:	409/1351 - (30%)
Similarity:	670/1351 - (49%)	Gaps:	152/1351 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKR----SNP 75
            |.||..||..||||:..|.|||....|.:|::.:.||...:|...:.|.|...::.:|    ..|
plant   207 FAKAGLFSTLSFWWLNSLIKRGNVKDLEEEDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQP 271

  Fly    76 SVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVIC 140
            |::::.:....:..:..|. |:..:.:..|..||.|...:        .::|..|.....|:|:.
plant   272 SILKVTVLCVWRELLTSGF-FAFMKIVAVSAGPLLLNAFI--------LVAEGNASFRYEGLVLA 327

  Fly   141 ML------VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLG 199
            :|      :..::...:.|....||.::|..|:..|.:|.|:::.||.........:|..:.|..
plant   328 VLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAY 392

  Fly   200 RFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAER 264
            |......:.|..|....:.::...:::..:|::....::.::..:...|..||....::......
plant   393 RIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTS 457

  Fly   265 TDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVR---LKEVKAIRGTAYIHAALGCTSMISPLS 326
            .|.|:|..||.:..::|:|:||||..|.:||.::|   ||.:||::.....:|.|..:|.:...:
plant   458 QDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWSSPVFVSA 522

  Fly   327 VFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKA 391
            ...|.|  .:|..||.|..|:|..:...::.|. |...|..|....:|.|:..|...|
plant   523 ATFATC--YFLDIPLRASNVFTFVATLRLVQDP-VRMIPDVIGVTIQAKVAFSRIATF------- 577

  Fly   392 EVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSAS 456
                 |||.:..|..:|:     ||::                       |..:..:::|:.|.|
plant   578 -----LEAPELQGGERRR-----KQRS-----------------------EGNQNAIIIKSASFS 609

  Fly   457 WDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQE 521
            |: ..|.....:.:.|.::|.....||.|.||:|||:.|..:|||.....|....:|.|:|.||.
plant   610 WE-EKGSTKPNLRNVSLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQT 673

  Fly   522 SWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLA 586
            :|:..|||||||:|....:|.||::.::...|::|:||||.||.|.:|||||:||||||.|:.||
plant   674 AWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLA 738

  Fly   587 RAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKI 651
            ||:|:.|||||||||.||||.|....:|...:.|.|:.|..:||||||.:|...:.:|||..|:|
plant   739 RALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEI 803

  Fly   652 MAQGSYQE-LQRSRQFQFLEQTQHDESGID--------THSVSSYLSRSDSEKSMEHQHNQLLRP 707
            ....:||| |.|||.||.|.....:.:|.:        |..|.. ::|..|.:|      ::|:|
plant   804 TEADTYQELLARSRDFQDLVNAHRETAGSERVVAVENPTKPVKE-INRVISSQS------KVLKP 861

  Fly   708 DEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQ 772
            ...::   ||::..|...:..|..|:.....      .|..|:.:...:|
plant   862 SRLIK---QEEREKGDTGLRPYIQYMNQNKG------YIFFFIASLAQVT--------------- 902

  Fly   773 IAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIR 837
            .||.:          .:.|..:..|..:|.::.|           :|:|.|..|...:::..::|
plant   903 FAVGQ----------ILQNSWMAANVDNPQVSTL-----------KLILVYLLIGLCSVLCLMVR 946

  Fly   838 TFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFI 902
            :.....||::.|..|..:|...:.||.|.|:::...||||:|.|.|:..||.|:|..|:..:|..
plant   947 SVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDVPFGLIFVVASS 1011

  Fly   903 IDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLT 967
            ::....:.::||..:.:|..:..:..:...::..|..|::.:.|:...:||.|.:...::..|..
plant  1012 VNTGCSLGVLAIVTWQVLFVSVPMVYLAFRLQKYYFQTAKELMRINGTTRSYVANHLAESVAGAI 1076

  Fly   968 TIRALQAQSALEQEFHEYQNTNTSAWF----------LFLSCTRAFALWSDVLCIVYMTAVTFSF 1022
            ||||...:....::.....:||.|.:|          ..|....|..|.|...|::.:...|||
plant  1077 TIRAFDEEERFFKKSLTLIDTNASPFFHSFAANEWLIQRLETVSAIVLASTAFCMILLPTGTFS- 1140

  Fly  1023 LLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFK 1087
                    ||.:|:|:.:..::.....:.::....|.|.:.||||:.:||....|| .|..|:.:
plant  1141 --------SGFIGMALSYGLSLNMGLVYSVQNQCYLANWIISVERLNQYTHLTPEA-PEVIEETR 1196

  Fly  1088 PKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNE 1152
            |...||..||:|..:.::||..:...|||.::.|.|...|||||||||:||:::|.::|||.  |
plant  1197 PPVNWPVTGRVEISDLQIRYRRESPLVLKGISCTFEGGHKIGIVGRTGSGKTTLISALFRLV--E 1259

  Fly  1153 ---GMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRS 1214
               |.|.:|.|||..||:|||||:..||||||.||:||:|:||||:.:.||.|:|:.||..:|:.
plant  1260 PVGGKIVVDGVDISKIGVHDLRSRFGIIPQDPTLFNGTVRFNLDPLCQHSDAEIWEVLGKCQLKE 1324

  Fly  1215 YVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSK 1279
            .|.....||:..:.:.|||:|:|||||.||.||:||.:::|::|||||::|..||.::|:|||.:
plant  1325 VVQEKENGLDSLVVEDGSNWSMGQRQLFCLGRAVLRRSRVLVLDEATASIDNATDLILQKTIRRE 1389

  Fly  1280 FAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLV 1330
            ||.|||:|:|||:.||||...||.:..|.:.|...|.:|::.......:||
plant  1390 FADCTVITVAHRIPTVMDCTMVLSISDGRIVEYDEPMKLMKDENSLFGKLV 1440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	409/1351 (30%)
		ABC_membrane	94..360	CDD:294371	60/274 (22%)
		ABCC_MRP_domain1	448..650	CDD:213217	91/201 (45%)
		ABC_membrane	821..1046	CDD:294371	56/234 (24%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	109/221 (49%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	407/1346 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720