DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC3

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1415	Identity:	420/1415 - (29%)
Similarity:	682/1415 - (48%)	Gaps:	238/1415 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTN------------KFAELW 66
            |:::|...|..:|.||..|...|            ::||||.|.|..            ||..:.
plant   245 PYSRAGILSLLTFSWMSPLIDIG------------NKKTLDLEDVPQLHDTDSVVGLAPKFRSML 297

  Fly    67 E--DELKRSNPSVVRMILRAY----GKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDI 125
            |  |..:||..:..::|...|    .:|.|....||..  |:...:.|..:...|.|.  |....
plant   298 ESPDGGERSGVTTFKLIKALYFTAQWEILVTAFFAFIY--TVASYVGPALIDTFVQYL--NGRRQ 358

  Fly   126 SENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRA 190
            ..:..|:..:......:|..::...:.|.:.:||.::|.||..:||.|.|.:|..|......|..
plant   359 YNHEGYVLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRTSGEI 423

  Fly   191 INILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIG----VSFMLSFIPLQAWAA 251
            ||.::.|..|......::||.|...::..|..:::||.:|::::..    :..||...|.    .
plant   424 INFMTVDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPF----G 484

  Fly   252 KKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAAL 316
            :....:::...|..|.|:|..:||::.::::|:..||..|...|.::|..|...::...|..|.:
plant   485 RMQERFQEKLMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVYNSAVI 549

  Fly   317 -----GCTSMISPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALV 376
                 |..:::| :|.|.| |  :.||.||.:.|:.:..:.|.:|.:.:... |.:|:.|.:..|
plant   550 SFVFWGAPTLVS-VSTFGA-C--ILLGIPLESGKILSALATFRILQEPIYNL-PDTISMIVQTKV 609

  Fly   377 SAKRCKDFL-LDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYD 440
            |..|...:| ||..:.::             ..::.|......||:..|.|
plant   610 SLDRLASYLCLDNLQPDI-------------VERLPKGSSDVAVEVINSTL-------------- 647

  Fly   441 PEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGID 505
                           |||.|.  :|..::|.:..:......||.|.||:||||.|:.|||||...
plant   648 ---------------SWDVSS--SNPTLKDINFKVFPGMKVAVCGTVGSGKSSLLSSLLGEVPKV 695

  Fly   506 KGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGE 570
            .|...|.|..:|.:|..|:..|.|.|||:|.:.....||.||::.|.|.:|:|:|..||.||:||
plant   696 SGSLKVCGTKAYVAQSPWIQSGKIEDNILFGKPMERERYDKVLEACSLSKDLEILSFGDQTVIGE 760

  Fly   571 RGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQ 635
            ||::||||||.|:.:|||:|:.|||||.|||.||||.|.|.|:|...:...|.:|..|.|||||:
plant   761 RGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLCSKSVIYVTHQVE 825

  Fly   636 YLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFLEQT-QHDES-----GIDTHSVSSYLSRSDSE 694
            :|...:.:|:|..|:|...|.|.::..|.. .|:|.. .|.|:     .:|.:||        ||
plant   826 FLPAADLILVMKDGRISQAGKYNDILNSGT-DFMELIGAHQEALAVVDSVDANSV--------SE 881

  Fly   695 KSMEHQHNQLLRP----DEHVED-----------------VNQEQQTVGSIKMHVYASYIK---- 734
            ||...|.|.:::.    ||.:|.                 :.:|::..||:.:.||..||.
plant   882 KSALGQENVIVKDAIAVDEKLESQDLKNDKLESVEPQRQIIQEEEREKGSVALDVYWKYITLAYG 946

  Fly   735 -ALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINA 798
             ||....|||.|  ||   :::..|.:|    |:.|
plant   947 GALVPFILLGQV--LF---QLLQIGSNY----WMAW----------------------------- 973

  Fly   799 TDPYIAPLLASDIQAGIRQE--LVLFYATILGATLIVY----LIRTFGFFKMCLRISLHLHDRLF 857
                 |..::.|:||.::..  ::::.|...|::|.:.    |:.|.|:     :.:..|..::.
plant   974 -----ATPVSEDVQAPVKLSTLMIVYVALAFGSSLCILLRATLLVTAGY-----KTATELFHKMH 1028

  Fly   858 RGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIP 922
            ..|.|:.|.||::..||||::|.|.|...||.:||:........:|.:.|::.:::..: ||:.
plant  1029 HCIFRSPMSFFDSTPSGRIMSRASTDQSAVDLELPYQFGSVAITVIQLIGIIGVMSQVS-WLVF- 1091

  Fly   923 AAIIGVILGMIRY--LYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFH-- 983
            ...|.|:...|.|  .|:..:|.:.||..:.::|:....::|..|.||||      :..|||.
plant  1092 LVFIPVVAASIWYQRYYIAAARELSRLVGVCKAPLIQHFSETISGATTIR------SFSQEFRFR 1150

  Fly   984 -------------EYQNTNTSAWFLF-----LSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFD 1030
                         ::.......|..|     .|.|..|:|       |::.::....:      |
plant  1151 SDNMRLSDGYSRPKFYTAGAMEWLCFRLDMLSSLTFVFSL-------VFLVSIPTGVI------D 1202

  Fly  1031 SGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSK 1095
            ....|||:.:..::..:..|.:.....|||::.||||:|:|...|||..| ..|..:|:..|||:
plant  1203 PSLAGLAVTYGLSLNTLQAWLIWTLCNLENKIISVERILQYASVPSEPPL-VIESNRPEQSWPSR 1266

  Fly  1096 GRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA-CNEGMIRIDD 1159
            |.:|..:.::||:|....||:.:..|.:...:.|||||||:|||::||::||:. .:.|.||||.
plant  1267 GEVEIRDLQVRYAPHMPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAGEIRIDG 1331

  Fly  1160 VDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLN 1224
            |:|..|||||||.::|||||||.:|.||:|.||||::|.:|:::|:||...:|...|......|:
plant  1332 VNILTIGLHDLRLRLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRKKEQKLD 1396

  Fly  1225 CRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIA 1289
            ..:.:.|.|:|:||||||||.|.:|:.:|||::|||||:||..||.|||:|:|..|:.|||:|||
plant  1397 SSVSENGDNWSMGQRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDCTVITIA 1461

  Fly  1290 HRLHTVMDSDRVLVMDAGEVRELGHPYELLQ-RTGGYLRQLVDNTGAATS 1338
            ||:.:|:|||.||::..|.:.|...|..||: ::..:.:.:.:.|..::|
plant  1462 HRISSVIDSDMVLLLSNGIIEEYDTPVRLLEDKSSSFSKLVAEYTSRSSS 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	420/1415 (30%)
		ABC_membrane	94..360	CDD:294371	64/274 (23%)
		ABCC_MRP_domain1	448..650	CDD:213217	88/201 (44%)
		ABC_membrane	821..1046	CDD:294371	56/250 (22%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	106/219 (48%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	418/1401 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720