DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC2

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1397	Identity:	441/1397 - (31%)
Similarity:	708/1397 - (50%)	Gaps:	173/1397 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLD-SERVTNKFAELWEDELKRSNPSV 77
            |...||.|.:..|.||..|...|.:.|||::::: :..|.| :|.:...|...|:.||::..|.:
plant   227 PEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVW-YLDTWDQTETLFTSFQHSWDKELQKPQPWL 290

  Fly    78 VRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICML 142
            :|.:..:.|..|. .|..:.|.....:.:.||.|..|:   .:.|.|......|:||..|.:.::
plant   291 LRALNNSLGGRFW-WGGFWKIGNDCSQFVGPLLLNQLL---KSMQEDAPAWMGYIYAFSIFVGVV 351

  Fly   143 VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLR----GRAINILSNDLGRFDV 203
            ..|:....:...:.:||.:||.||...::||.|::    :|:|.|    |:..|:::.|......
plant   352 FGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRL----TNEGRRKFQTGKITNLMTTDAESLQQ 412

  Fly   204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268
            ....||..|..|...|:...|:|:::|::::||...::...|||.....|.....:...:|||.|
plant   413 ICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKLTKEGLQRTDKR 477

  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSM--ISPLSVFLAL 331
            :.||||::..:..:|.||||.||...:..||..|:...|.:    ..||..:|  ::.:.|.:.:
plant   478 IGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKS----QLLGALNMFILNSIPVLVTI 538

  Fly   332 CS---YVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEV 393
            .|   :..||..||..:.:|..|.|.:|...:... |..||.:..|.||.||.::.|...::.
plant   539 VSFGVFTLLGGDLTPARAFTSLSLFAVLRFPLFML-PNIITQVVNANVSLKRLEEVLATEERI-- 600

  Fly   394 PINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWD 458
                                           ||.|..:          |..:..:.::|...|||
plant   601 -------------------------------LLPNPPI----------EPGEPAISIRNGYFSWD 624

  Fly   459 TSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMV--HGKISYASQE 521
            :.....  .:.:.:.|:...:|.||||..|.||:|.::.:|||:.. ..:|:|  .|.::|..|.
plant   625 SKGDRP--TLSNINLDVPLGSLVAVVGSTGEGKTSLISAILGELPA-TSDAIVTLRGSVAYVPQV 686

  Fly   522 SWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLA 586
            ||:|..|:||||:|...::..:|::.:.|..|:.|:||||.||||.:|||||::|||||.|||:|
plant   687 SWIFNATVRDNILFGSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGVNISGGQKQRVSMA 751

  Fly   587 RAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKI 651
            ||||..:|:|:.||||||:|.|||:.:|::||:..|..|.|:|||:|:.:|..|:.::|:..|.:
plant   752 RAVYSNSDVYIFDDPLSALDAHVGQQVFEKCIKRELGQKTRVLVTNQLHFLSQVDRIVLVHEGTV 816

  Fly   652 MAQGSYQELQRSRQ-FQFL-----------------EQTQHDESGIDTHSVSS-YLSRSDSEKSM 697
            ..:|:|:||..:.. ||.|                 |..|..|..:...:.:. .:..||.:||.
plant   817 KEEGTYEELSSNGPLFQRLMENAGKVEEYSEENGEAEADQTAEQPVANGNTNGLQMDGSDDKKSK 881

  Fly   698 EHQH---NQLLRPDEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGV 759
            |...   ..:|        :.||::..|.:...|...|..||...:   :|:.|.:|
plant   882 EGNKKGGKSVL--------IKQEERETGVVSWRVLKRYQDALGGAW---VVMMLLLC-------- 927

  Fly   760 DYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYA 824
             |.|:      |...|..:|.|...||.          .|.....||..:           |.||
plant   928 -YVLT------EVFRVTSSTWLSEWTDA----------GTPKSHGPLFYN-----------LIYA 964

  Fly   825 TILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDT 889
            .:....::|.|..::......|..:..|||.:...|.||.|.||:||..|||:|||:||:..:|.
plant   965 LLSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHSILRAPMSFFHTNPLGRIINRFAKDLGDIDR 1029

  Fly   890 DLP---HTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESIS 951
            .:.   :..:..::.::....::.||:..:.|.::|..::  ..|...| |.||:|.|||::|||
plant  1030 TVAVFVNMFMGQVSQLLSTVVLIGIVSTLSLWAIMPLLVL--FYGAYLY-YQNTAREVKRMDSIS 1091

  Fly   952 RSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVL--CIVY 1014
            ||||::...:...||:||||.:|...:........:.|.....:.:...|...:..:.|  .:::
plant  1092 RSPVYAQFGEALNGLSTIRAYKAYDRMADINGRSMDNNIRFTLVNMGANRWLGIRLETLGGLMIW 1156

  Fly  1015 MTAVTFSFLLLKD------EFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTE 1073
            :||   ||.::::      :..:..:||.:.::..:|.:....:|..:..||.:.:||||..|.|
plant  1157 LTA---SFAVMQNGRAENQQAFASTMGLLLSYALNITSLLTGVLRLASLAENSLNAVERVGNYIE 1218

  Fly  1074 QPSEALLETP--EKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGA 1136
            .|.||   .|  |..:|...|||.|.|:|.:..|||.|:..|||..::|.|.|.:|:||||||||
plant  1219 IPPEA---PPVIENNRPPPGWPSSGSIKFEDVVLRYRPQLPPVLHGVSFFIHPTDKVGIVGRTGA 1280

  Fly  1137 GKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSD 1200
            ||||::.::||:. ..:|.|.|||.|:...||.|||..:.||||.|||||||:|:||||..|.:|
plant  1281 GKSSLLNALFRIVEVEKGRILIDDCDVGKFGLMDLRKVLGIIPQSPVLFSGTVRFNLDPFGEHND 1345

  Fly  1201 EEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVD 1265
            .::|::|....|:..:.....||:..:.:.|.|||||||||:.|:||:||.:|||::|||||.||
plant  1346 ADLWESLERAHLKDTIRRNPLGLDAEVSEAGENFSVGQRQLLSLSRALLRRSKILVLDEATAAVD 1410

  Fly  1266 PETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLV 1330
            ..||.|||:|||.:|..||:|.|||||:|::|.|::||:|:|.|:|...|..||...|....::|
plant  1411 VRTDALIQKTIREEFKSCTMLIIAHRLNTIIDCDKILVLDSGRVQEFSSPENLLSNEGSSFSKMV 1475

  Fly  1331 DNTGAATSFALQQAAEQSYSKQILGDDTAAED 1362
            .:||||.:         .|.:.::.|:..|:|
plant  1476 QSTGAANA---------EYLRSLVLDNKRAKD 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	437/1376 (32%)
		ABC_membrane	94..360	CDD:294371	73/274 (27%)
		ABCC_MRP_domain1	448..650	CDD:213217	86/203 (42%)
		ABC_membrane	821..1046	CDD:294371	62/235 (26%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	113/219 (52%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	441/1397 (32%)
		ABC_membrane	309..570	CDD:279056	73/271 (27%)
		ABCC_MRP_domain1	614..815	CDD:213217	86/203 (42%)
		ABC_membrane	925..1179	CDD:294371	72/295 (24%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	113/219 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720