DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC13

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001323940.1	Gene:	ABCC13 / 815414	AraportID:	AT2G07680	Length:	1426	Species:	Arabidopsis thaliana

Alignment Length:	1352	Identity:	402/1352 - (29%)
Similarity:	666/1352 - (49%)	Gaps:	164/1352 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 WWMRDLF---------KRGLQGPLTDEELYQHRKTLDSERVTNKFAELWE-DELKR-SNPSVVRM 80
            ||  |||         |.|....|..|.|......:|...........|: .|... |.||::..
plant   195 WW--DLFTFGYIGSIMKHGSVKQLELENLLTLPPEMDPFTCCENLLRCWQLQECNNYSTPSLIWS 257

  Fly    81 ILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPV 145
            |...||..:..:||....::.| ....||.|..|:.|.   :.....:..|..|:.:....:...
plant   258 IYGVYGWPYFRLGLLKVFNDCI-GFAGPLLLNRLIKYL---EKGSGSSVGYTLAISLGFISIFKS 318

  Fly   146 ITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALC-FLH 209
            .....:.|.:.::..|||.::..:||||.|.|:.::.:....|.....:|.|..|. |.|| .||
plant   319 FLDTQYTFRLSKLKLKLRSSIMSVIYRKCLWVNTANRSGFSEGEIQTFMSVDADRI-VNLCNSLH 382

  Fly   210 DTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNE 274
            |.|..|::..:..:|:|.::..:.:.|::..:..||:..|.:...|...:...:..|.|::...|
plant   383 DLWSLPLQIGIALYLLYTQVKFAFLSGLAITILLIPVNKWISVLIASATEKMMKLKDERIRKTGE 447

  Fly   275 IIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCS---YVY 336
            ::..|:.:|||.|:..||..:.|.|..||..:....|:.|  .|....:......:||:   :..
plant   448 LLTNIRTLKMYGWDNWFADWLKETRATEVTHLATRKYLDA--WCVFFWATTPTLFSLCTFGLFAL 510

  Fly   337 LGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQ 401
            :|..|.|..|:|..:.||.|...:.:| |..|..:.:|.:|.:|...||.
plant   511 MGHQLDAATVFTCLALFNSLISPLNSF-PWVINGLIDAFISTRRVSKFLC--------------- 559

  Fly   402 QTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKK--CVVLKNVSASWDTS-DGH 463
                                        .:.|:|....|...|.:  .|.:::.|.:|.:: :..
plant   560 ----------------------------CLEHSRDFSIDSGFTSEDLAVCVEDASCTWSSNVEED 596

  Fly   464 ANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGT 528
            .|..|:..|..:...:..||:|.||:||:|.||.||||:....|..:::|.::|..|..|:..||
plant   597 YNLTIKQVSLRVPKGSFVAVIGEVGSGKTSLLNSLLGEMRCVHGSILLNGSVAYVPQVPWLLSGT 661

  Fly   529 IRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKA 593
            :|:||:|.:.::.:||.:.:..|.|:.|:.|:..||:..:|::|::|||||:||.:||||||..:
plant   662 VRENILFGKPFDSKRYFETLSACALDVDISLMVGGDMACIGDKGLNLSGGQRARFALARAVYHGS 726

  Fly   594 DIYLLDDPLSAVDTHVGKHIFDRC-IRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSY 657
            |:|||||.|||||:.||..|..|. :...|:.|.|::.||.:|.:...:.:::|..||:...||.
plant   727 DMYLLDDVLSAVDSQVGCWILQRALLGPLLNKKTRVMCTHNIQAISCADMIVVMDKGKVNWSGSV 791

  Fly   658 QELQRSRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVNQ------ 716
            .::.:|....|....:.|.|.      .::|::.....|::         ::.|:::::
plant   792 TDMPKSISPTFSLTNEFDMSS------PNHLTKRKETLSIK---------EDGVDEISEAAADIV 841

  Fly   717 --EQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIM---LTGVDYFLSRWVIWEEQIAVN 776
              |::..|.::|.||.:|  |:.|.:.:.|||  .|.|.:|   ..|.|.:||.||
plant   842 KLEERKEGRVEMMVYRNY--AVFSGWFITIVI--LVSAVLMQGSRNGNDLWLSYWV--------- 893

  Fly   777 RTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGF 841
                  ::|...:::     .:|..|:               :||....|:.:  |:.|:|.|.|
plant   894 ------DKTGKGVSH-----YSTSFYL---------------MVLCIFCIINS--ILTLVRAFSF 930

  Fly   842 FKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVS 906
            ....|:.::|:|:.|...:..|...||:...|||||||||.|:.|:|..||..|...||..:.:.
plant   931 AFGGLKAAVHVHNALISKLINAPTQFFDQTPSGRILNRFSSDLYTIDDSLPFILNILLANFVGLL 995

  Fly   907 GVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRA 971
            |::::::......|:.......|...::..|.:|||.::||:|:||||:::...:|..|.:||||
plant   996 GIIVVLSYVQVLFLLLLLPFWYIYSKLQVFYRSTSRELRRLDSVSRSPIYASFTETLDGSSTIRA 1060

  Fly   972 LQAQSALEQEFHE----YQNTNTSAWF--LFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFD 1030
            .:::......|.|    ||.|:.|...  |:|| .|...|.|.::..|.:.||..|.......|.
plant  1061 FKSEEHFVGRFIEHLTLYQRTSYSEIIASLWLS-LRLQLLGSMIVLFVAVMAVLGSGGNFPISFG 1124

  Fly  1031 S-GDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPS 1094
            : |.||||:.::..:..:....:....|.|.:|.||||||:|.:.|.|. :..|:....|  ||.
plant  1125 TPGLVGLALSYAAPLVSLLGSLLTSFTETEKEMVSVERVLQYMDVPQEE-VSGPQSLSDK--WPV 1186

  Fly  1095 KGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRL--ACNEGMIRI 1157
            .|.:||.|..:||.....|.|..::|||:....:|::||||||||||:.::|||  .|: |.|.:
plant  1187 HGLVEFHNVTMRYISTLPPALTQISFTIQGGMHVGVIGRTGAGKSSILNALFRLTPVCS-GEILV 1250

  Fly  1158 DDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGG 1222
            |..:|.|:.:.:|||.::::||.|.||.|:||.||||:....|..:|:.|...::::.|.: :||
plant  1251 DGKNISHLPIRELRSCLAVVPQSPFLFQGSLRDNLDPLGLSEDWRIWEILDKCKVKAAVES-VGG 1314

  Fly  1223 LNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLT 1287
            |:..:.:.|.:||||||||:|||||:|:.:|||.:||.|||:|..|..|:..||.|:....||:|
plant  1315 LDSYVKESGCSFSVGQRQLLCLARALLKSSKILCLDECTANIDVHTASLLHNTISSECKGVTVIT 1379

  Fly  1288 IAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSF 1339
            ||||:.||:|.|.:|::|.|.:.|.|.|..|||          |::...:||
plant  1380 IAHRISTVVDLDSILILDRGILVEQGKPQHLLQ----------DDSSTFSSF 1421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	402/1352 (30%)
		ABC_membrane	94..360	CDD:294371	65/269 (24%)
		ABCC_MRP_domain1	448..650	CDD:213217	76/203 (37%)
		ABC_membrane	821..1046	CDD:294371	73/231 (32%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	98/220 (45%)
ABCC13	NP_001323940.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I4365
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720