Protein Alignment rdog and Abcc3

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001350116.1
• Gene: Abcc3 / 76408
• MGIID: 1923658
• Length: 1523
• Species: Mus musculus
• Alignment Length: 1456
• Identity: 476/1456 - (32%)
• Similarity: 738/1456 - (50%)
• Gaps: 261/1456 - (17%)

  Fly    11 PKN------PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELW--- 66
            |:|      |...|.|||:.||||...|...|.:.||.|.:|:...:...|.:|..:..|.|
Mouse   199 PENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQ 263

  Fly    67 ------------------EDEL------KRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLM 107
                              ||.:      |...||.:|.::|.:....: |...|::.:.:...:.
Mouse   264 QNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLL-MSACFNLIQNLLGFVN 327

  Fly   108 PLFLGGLVGYFATNQTDISENTA-----YLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALS 167
            |..|..|:.:       ||:.||     :|.|..:.:...:..:..|.:...||.:..:||.|:.
Mouse   328 PQLLSILIRF-------ISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAII 385

  Fly   168 GLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGIS 232
            |:||||.|.::.|...:...|..:|::|.|..||.....|::..|..|::.||..:.:::.:|.|
Mouse   386 GVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPS 450

  Fly   233 AVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAE 297
            |:.||:.::..|||....:.|...|:....:..|.|:|||:||:.||:|:|:||||.||...:..
Mouse   451 ALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKG 515

  Fly   298 VRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCS-----------YVYLGDP--LTAQKVYTV 349
            :|..|::.:|..||:.|          :|.|:.:|:           |||:.:.  |.|:|.:..
Mouse   516 IRQSELQLLRKGAYLQA----------ISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVS 570

  Fly   350 SSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKD 414
            .|.||:|...: ...|..|:.:.:|.||.||.:|||              ||
Mouse   571 LSLFNILKIPL-NMLPQLISGLTQASVSLKRIQDFL--------------NQ------------- 607

  Fly   415 KQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTS--DGHANCA------IEDF 471
                                  .:.||:    ||..|.:|..:..:  :|....|      :...
Mouse   608 ----------------------NELDPQ----CVERKTISPGYAITIHNGTFTWAQDLPPTLHSL 646

  Fly   472 STDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFV 536
            :..|....|.|||||||.||||.::.||||:...:|...|.|.::|..|::|:...|:::|::|.
Mouse   647 NIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFG 711

  Fly   537 EDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDP 601
            :..|.:||::.::.|.|..|:::||.||.|.:||:|::|||||:.|||||||||..|:|:|||||
Mouse   712 QPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDP 776

  Fly   602 LSAVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQE-LQRS 663
            |||||:||.|||||:.|  ...|:.|.|:||||.:.:|...:.::::..|::...|.|.. ||..
Mouse   777 LSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEMGHYSALLQHD 841

  Fly   664 RQF-QFLEQTQHDESGID---------------THSVSSYLSRSDSEKSMEHQHNQLLR------ 706
            ..| .||.....||...|               ..::|::...:|:|.::.....|.:|
Mouse   842 GSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLS 906

  Fly   707 ----------PDEHVEDVNQE------QQT----------VGSIKMHVYASYIKALDSTFLLGIV 745
                      |.:|...:.:|      ::|          .|::|:.||..|.|:      :|:.
Mouse   907 SEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDYAKS------MGLC 965

  Fly   746 ISLFVC--------ARIMLTGVDYFLSRWV-IWEEQIAVNRTTTLLNETDTTIANDTLPINATDP 801
            .:|.:|        |.|   |.:.:||.|. ..||....|:|:..|.                 .
Mouse   966 TTLSICLLYGGQSAAAI---GANVWLSAWSNDAEEHGQQNKTSVRLG-----------------V 1010

  Fly   802 YIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMY 866
            |.|        .||.|.|::..:..   |::|..|:       ..|:   ||:.|.....|:...
Mouse  1011 YAA--------LGILQGLLVMLSAF---TMVVGAIQ-------AARL---LHEALLHNKIRSPQS 1054

  Fly   867 FFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCL-AFIIDVSGVVIIVAIANYWLLI--PAAIIGV 928
            ||:|..||||||||||||..:|..|..|:|..| :|...:|.:::|||....::::  |.|   |
Mouse  1055 FFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLA---V 1116

  Fly   929 ILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNT----N 989
            :.|.::..||.|||.:||||||||||:||..::|..|.:.|||.    ...|:|....:|    |
Mouse  1117 LYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAY----GRIQDFKVLSDTKVDNN 1177

  Fly   990 TSAWFLFLSCTRAFALWSDVL--CIVYMTAVTFSFLLL-KDEFDSGDVGLAILHSTTMTGMCQWG 1051
            ..:.:.:::..|...:..:.:  |:|...|:   |.:: ::..:.|.|||::.::..:|....|.
Mouse  1178 QKSSYPYIASNRWLGVHVEFVGNCVVLFAAL---FAVIGRNSLNPGLVGLSVSYALQVTMALNWM 1239

  Fly  1052 MRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLK 1116
            :|..::||:.:.:||||.||::..:||.........|:. ||::|.:||.|:.:||.|....|||
Mouse  1240 IRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAPEG-WPTRGMVEFRNYSVRYRPGLELVLK 1303

  Fly  1117 DLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQD 1180
            ::...::..||:||||||||||||:...:|| |...||.|.||.:::.||||||||||::|||||
Mouse  1304 NVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQD 1368

  Fly  1181 PVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLA 1245
            |:|||||||.||||....|:|::|:||....|.::||:...||:.:..:||.|.|||||||||||
Mouse  1369 PILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLA 1433

  Fly  1246 RAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVR 1310
            ||:||.:::|::|||||.:|.|||.|||.|||::|..||||||||||:|:||.:||||:|.|.|.
Mouse  1434 RALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVA 1498

  Fly  1311 ELGHPYELLQRTGGYLRQLVDNTGAA 1336
            |...|..|: ..||....:..:.|.|
Mouse  1499 EFDSPVNLI-AAGGIFYGMAKDAGLA 1523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	470/1432 (33%)
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	474/1453 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	903..923		2/19 (11%)