DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and abcc12

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_009301629.1	Gene:	abcc12 / 568482	ZFINID:	ZDB-GENE-050517-25	Length:	1368	Species:	Danio rerio

Alignment Length:	1398	Identity:	465/1398 - (33%)
Similarity:	734/1398 - (52%)	Gaps:	184/1398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELY--QHRKTLDSERVT-NKFAELWEDELKR-- 72
            :|...|.|||..||.||..:..|..:..|.::.|:  .|    |...:. .:|..||::|:.|
Zfish    67 HPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLFLSPH----DGAHINGERFQRLWDEEVARVG 127

  Fly    73 -SNPSVVRMILRAYGKIFVPMGLAFSISETICKSLM---PLFLG-GLVGYFATNQTDISENTAYL 132
             ...|:..:|:|.....|:...||         |:|   .:|:| .::.|...|..:.||.:..:
Zfish   128 LEKASLSAVIMRFQKTRFIVSFLA---------SVMFAFAVFVGPSILVYEILNYVEQSEPSTVV 183

  Fly   133 YAMGIVICMLVPVIT--FHPFIFYIFQVGTKLRL--ALSGLIYRKVLQVSKSSSNDGLRGRAINI 193
            :.:|:.:.:.:...:  |...:.:...:.|.:|:  |.|.|.::|:  :|..|......|..||:
Zfish   184 HGVGVCVALFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKI--ISLRSLTTITVGETINV 246

  Fly   194 LSNDLGRFDVALCFLHDTWKGPMESILIGFLMYR--EIGISAVIGVSFMLSFIPLQAWAAKKAAY 256
            |::|..|...|:.|  .|:...:..:||..::|.  .:|.:|:||:...|.|:|:|...|:....
Zfish   247 LTSDGYRLFDAVIF--GTFLLCVPVLLIICIIYACFILGYTALIGILVYLIFLPIQFSIARLIGV 309

  Fly   257 YRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAA-LGCTS 320
            :|:.....||.||:.|||::..|::|||||||:||.:.|.::|..|...::...|:.:. ...|:
Zfish   310 FRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSLNSSLTT 374

  Fly   321 MISPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFL 385
            ::..|:..:....:..|..||.....||:.:.||.:..|| ...|.|:..:|||.|:..|.|..:
Zfish   375 IVPTLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSM-GLLPFSVKAVAEAKVALTRLKRIM 438

  Fly   386 LDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVL 450
            |                 .:|.:....:|  ||::|                         .:|:
Zfish   439 L-----------------VQNPKGYLTQD--KNMDL-------------------------ALVM 459

  Fly   451 KNVSASWDTSD------------------GHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNV 497
            :..:.||..:|                  ..:..::.:.|..:...:|..|.|.||:||:|.::.
Zfish   460 EKATFSWSPTDDKNTSQMPENPSQNGKHKAESQPSLRNISLTLSKGSLLGVCGNVGSGKTSLISS 524

  Fly   498 LLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPR 562
            :|.::.:..|....:|.::|.||::|:|.||:||||:..|.::|.||..|:..|.|:.|:.:||.
Zfish   525 ILEQMHLLSGSVSANGTLAYVSQQAWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPY 589

  Fly   563 GDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIR 627
            ||.|.:||||::||||||.|||||||||...||:||||||||||.|||||||:.||:..|..|..
Zfish   590 GDQTEIGERGINLSGGQKQRVSLARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECIKKELKGKSV 654

  Fly   628 ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS--RQFQFLEQTQHDESGIDTHSVSSYLSR 690
            ||||||:|||...:.::|:.:|:|...|::.:|.::  |..|.:.....:::.          .|
Zfish   655 ILVTHQLQYLEFCDEVMLLDNGEIKEAGTHSDLMKTKGRYSQLITNVHLEQNN----------ER 709

  Fly   691 SDSEKSMEHQHNQLLRPDE----HVED-----------------------------VNQEQQTVG 722
            :||:...||..::...|||    .:|:                             |.:|....|
Zfish   710 ADSKPQTEHNDSEQTNPDEPKANGIENPAFDMSDEKPATNETPKDSSETKGKKDQLVTREVAQEG 774

  Fly   723 SIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWV-IWEEQIAVNRTTTLLNETD 786
            |:....|..|.:|.....||.:|:.||.    :|.|...|.:.|: .|.:|.:.|.:::......
Zfish   775 SVTWRTYHQYCQAAGGYILLFLVVLLFT----LLVGSTAFSNWWLSYWLDQGSGNNSSSNATSNS 835

  Fly   787 TTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILG----ATLIVYLIRTFGFFKMCLR 847
            ..|:.:            |.|:             ||..:.|    |.:::.:::.:.|.|:.||
Zfish   836 GNISEN------------PDLS-------------FYQMVYGVIIIAMIVLSILKGYTFTKVTLR 875

  Fly   848 ISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIV 912
            .|..|||.:|:.|..:.|.||:|..:||::||||||...||..||..:.:.|.|.:.|:..::.:
Zfish   876 SSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTI 940

  Fly   913 AIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSA 977
            .|...:|||...|:|:|...|.|::..:.|.:||:|::||||..|||..|.|||:||.|...:..
Zfish   941 CIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQ 1005

  Fly   978 LEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDV-GLAILHS 1041
            ..:.|....:.|::.:.||.:.||..:.|.|||.......|:...:|..:|..:..: |||:.::
Zfish  1006 YIERFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSLFVVLSPNETINPSLKGLALSYT 1070

  Fly  1042 TTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKP---KSEWPSKGRIEFINF 1103
            ..:||:.|:.:|.:.|:|.:.|||||:|||.   :..:.|.|.:.|.   .:.||.:|.|.|.|:
Zfish  1071 IQLTGILQFVVRLSTEVEAKFTSVERLLEYI---TSCVSEGPRRVKDANIPAGWPQEGTITFKNY 1132

  Fly  1104 KLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGL 1167
            .:||......||.:||.||.|.||:|||||||:||||:..::|||| ..||.|.|||:||..:||
Zfish  1133 SMRYRDNTPIVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTILIDDMDICKLGL 1197

  Fly  1168 HDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGS 1232
            .|||||:|:||||||||.||:||||||.:...|||:|.||....::..:|.|...|...:.:.|.
Zfish  1198 KDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLPEKLQSPVVENGE 1262

  Fly  1233 NFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMD 1297
            |||||:|||:|:|||:||::||:::|||||::|.|||.|||.|||..|.|||:||||||::||::
Zfish  1263 NFSVGERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLE 1327

  Fly  1298 SDRVLVMDAGEVRELGHPYELLQRTGGYLRQLV 1330
            |||:||||.|:|.|...|.:|:||.......|:
Zfish  1328 SDRILVMDQGKVIEFDPPQDLIQRPNSLFASLL 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	465/1398 (33%)
		ABC_membrane	94..360	CDD:294371	72/276 (26%)
		ABCC_MRP_domain1	448..650	CDD:213217	92/219 (42%)
		ABC_membrane	821..1046	CDD:294371	76/229 (33%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	125/219 (57%)
abcc12	XP_009301629.1	CFTR_protein	68..1366	CDD:273530	465/1397 (33%)
		ABC_membrane	149..414	CDD:294371	72/277 (26%)
		ABCC_MRP_domain1	457..677	CDD:213217	92/219 (42%)
		ABC_membrane	809..1077	CDD:294371	86/292 (29%)
		ABCC_MRP_domain2	1125..1345	CDD:213211	125/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660