DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcb9

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	666	Identity:	160/666 - (24%)
Similarity:	294/666 - (44%)	Gaps:	116/666 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 LRPD-EHVEDVNQ---------EQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGV 759
            :||| |.:|..|:         .:|..|: .:....||.|. |..||:.....|.|.| :..|.:
Mouse   140 VRPDAEALEPGNEGFHGEGGAPAEQASGA-TLQKLLSYTKP-DVAFLVAASFFLIVAA-LGETFL 201

  Fly   760 DYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLA--SDIQAGIRQELVLF 822
            .|:..|.:                  |:.:...::....|...:..|||  |.:.||||.
Mouse   202 PYYTGRAI------------------DSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGIRG----- 243

  Fly   823 YATILGATLIVYLIRTFGFFKMCL-RISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRT 886
                             |.|.:.. |:::.|.:.|||.:......||:.|.:|.:::|.:.|...
Mouse   244 -----------------GIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 291

  Fly   887 VDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGV-ILGMIRYLYVNTSRSVKRLESI 950
            |...:...:...|...:.|:|||:.: .:..|.|.....:|. |:.|:..:|   .:..|||...
Mouse   292 VSDLVSQNINIFLRNTVKVTGVVVFM-FSLSWQLSLVTFMGFPIIMMVSNIY---GKYYKRLSKE 352

  Fly   951 SRSPV---FSLTNQTFQGLTTIRAL-----QAQSALE--QEFHEYQNTNTSAWFLFLSCTRAFAL 1005
            .:|.:   .:...:|...:.|:|:.     :|:..|.  |:.::......:|:..:        :
Mouse   353 VQSALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSY--------V 409

  Fly  1006 W-SDVLCIVYMTAVTF--SFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQT-AELENQMTSVE 1066
            | |.:..:|...::.:  ..|::..:..||::...|::...: |.|...:... :.|...:.:.|
Mouse   410 WGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVL-GDCMESVGSVYSGLMQGVGAAE 473

  Fly  1067 RVLEYTEQPSEALLETPEKFKPKSEWPS--KGRIEFINFKLRYSPK-EAPVLKDLNFTIEPREKI 1128
            :|.|:.::       .|......|..|.  :||::|.|....|..: ...||::::|::.|.:..
Mouse   474 KVFEFIDR-------QPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVT 531

  Fly  1129 GIVGRTGAGKSS---IIQSIFRLACNEGMIRIDDVDIEHIGLHD---LRSQVSIIPQDPVLFSGT 1187
            .:||.:|:||||   |:::.:.|  ..|.:.:|.   :.||.:|   |...:|::.|:||||:.:
Mouse   532 ALVGPSGSGKSSCVNILENFYPL--QGGRVLLDG---KPIGAYDHKYLHRVISLVSQEPVLFARS 591

  Fly  1188 LRYNLD------PMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLAR 1246
            :..|:.      |.     |.:.:|........::..|..|.:....:.|:..|.||:|.|.:||
Mouse   592 ITDNISYGLPTVPF-----EMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMAR 651

  Fly  1247 AILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRE 1311
            |::|:..:||:||||:.:|.|::.||||.|.......|||.|||||.||..:..::|:|.|.|.:
Mouse   652 ALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQ 716

  Fly  1312 LGHPYELLQRTGGYLR 1327
            .|...:||.:.|.|.:
Mouse   717 QGTHQQLLAQGGLYAK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	160/666 (24%)
		ABC_membrane	94..360	CDD:294371
		ABCC_MRP_domain1	448..650	CDD:213217
		ABC_membrane	821..1046	CDD:294371	43/239 (18%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	74/231 (32%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	160/666 (24%)
		ABC_membrane	189..451	CDD:279056	59/314 (19%)
		ABCC_TAP	489..714	CDD:213215	74/234 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000