DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcb10

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	663	Identity:	163/663 - (24%)
Similarity:	274/663 - (41%)	Gaps:	135/663 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 LLGIV----------ISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLP 795
            |||:|          :.....:.::.....:||.|.:                        |.:.
Mouse   125 LLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRII------------------------DVIY 165

  Fly   796 INATDPY---IAPLLASDIQAGIRQELVLFYATILGAT---LIVYLIRTFGFFKMCLRISLHLHD 854
            .|.::.|   :..|.|           ||....:.||.   :.|||:::.|     ..|...|..
Mouse   166 TNPSEGYGDSLTRLCA-----------VLTCVFLCGAAANGIRVYLMQSSG-----QSIVNRLRT 214

  Fly   855 RLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVS---GVVIIV--AI 914
            .||..|.|..:.||:...:|.::||.|.|...:...:...|.|.|......|   |::..|  ::
Mouse   215 SLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSL 279

  Fly   915 ANYWLLI--PAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSA 977
            |.:.|.:  |.:::.||.|  |||     |.:.:....|.:....|..:....:.||||...:..
Mouse   280 ATFVLSVVPPISVLAVIYG--RYL-----RKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMT 337

  Fly   978 LEQEFHEYQNTNTSAWFLFLSCTRAFA---------LWSD--VLCIVYMTAVTF----------- 1020
               |..:|  |......|.|:...|.|         |..:  ||.::|...:..
Mouse   338 ---EVEKY--TGRVDQLLQLAQKEALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMTVGELS 397

  Fly  1021 SFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTE-QP----SEALL 1080
            |||:..........||:..:|..|.|:...|               |:.|..| ||    :|.::
Mouse   398 SFLMYAFWVGLSIGGLSSFYSELMKGLGAGG---------------RLWELLERQPRLPFNEGMV 447

  Fly  1081 ETPEKFKPKSEWPSKGRIEFINFKLRYSPK-EAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQS 1144
            ...:.|        :|.:||.|....|..: |..|.:|.:.:|.......:||.:|:|||:::..
Mouse   448 LDEKTF--------QGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSL 504

  Fly  1145 IFRL-ACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFS----GTLRYNLDPMDERSDEEMW 1204
            :.|| ..|.|.:.:|..||..:....|||::..:.|:|||||    ..:.|..|.:...:.:::.
Mouse   505 LLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVE 569

  Fly  1205 KALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETD 1269
            :|........::.:...|.:..:.:.|...|.||:|.:.:|||:|::.|||::||||:.:|.|.:
Mouse   570 RAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENE 634

  Fly  1270 KLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTG 1334
            .|:|:.:.......|||.|||||.|:.:::.|.|:|.|::.|.|...|||.:..|..|:|::.
Mouse   635 HLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLMNK-- 697

  Fly  1335 AATSFALQQAAEQ 1347
              .||.....|||
Mouse   698 --QSFLSYNGAEQ 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	160/657 (24%)
		ABC_membrane	94..360	CDD:294371
		ABCC_MRP_domain1	448..650	CDD:213217
		ABC_membrane	821..1046	CDD:294371	60/256 (23%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	70/224 (31%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	157/643 (24%)
		ABC_membrane	142..403	CDD:279056	65/312 (21%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	75/243 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000