DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and abcc13

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_017209479.1	Gene:	abcc13 / 559093	ZFINID:	ZDB-GENE-050517-26	Length:	1020	Species:	Danio rerio

Alignment Length:	1328	Identity:	263/1328 - (19%)
Similarity:	478/1328 - (35%)	Gaps:	436/1328 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YQHRKTL--DSER----VTNK-------FAELWEDELKRSNPSVVRMILRAYGKIFVPMGLAFSI 98
            |:.|..|  ||.|    ||:|       ...||    |..:||:::::|             ..:
Zfish    70 YKERSDLEDDSGRKSLLVTSKTNAGYSLLYTLW----KTFHPSLIKIVL-------------LRL 117

  Fly    99 SETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLR 163
            |..:...|:|:.:..:: .|:..|..... |.|.||:.:...:.....:.|.|......:.....
Zfish   118 SSDLFSILVPITIRWVI-LFSERQAMFGW-TGYTYALVVFGALCCGAFSQHHFEKRSRIITANAH 180

  Fly   164 LALSGLIYRKVLQVSKSSSN---------DGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESI 219
            ..|||.:|||:..:|.|.|:         :.:.|.|..:     ....|.|..:   |..|:...
Zfish   181 AILSGTVYRKIKTLSLSHSSRWHSDTSHREDMLGEAERV-----AELVVTLACI---WSSPLRVT 237

  Fly   220 LIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKM 284
            |...|::.::|.|.::||:.:|..||:::...:||...|:......:...:|:.|::...|.:|:
Zfish   238 LYLGLLWAKLGPSVLVGVTLLLVLIPVKSAVERKAKQLRRTHRVIREKSEQLIKEMLHKYQALKL 302

  Fly   285 YAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLALCSYVYL--GDPLTAQKV 346
            ..||..|.:.:.|.|.:|::.:|...::.|.....|:..| |.:|.:|.::|.:  |:.||:.::
Zfish   303 LTWESWFFQRVTESRTRELEMLRIQGFLTAFSMLDSICMPFLVIFSSLGAFVLVDDGNVLTSSQI 367

  Fly   347 YTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKIS 411
            :|...:|.:|...::.|.
Zfish   368 FTSVCFFRLLRPPLLEFL----------------------------------------------- 385

  Fly   412 KKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIK 476
                        .|.|                     |||....|:
Zfish   386 ------------GLFS---------------------VLKQAQQSF------------------- 398

  Fly   477 DQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNE 541

Zfish   399 ----------------------------------------------------------------- 398

  Fly   542 RRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVD 606
                     |.||:                                       |:|.:|
Zfish   399 ---------CYLEK---------------------------------------IFLTED------ 409

  Fly   607 THVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFLEQ 671
                                                   :|:.:.:.:|:.:|.......|..::
Zfish   410 ---------------------------------------LGTSQFLTKGATEESSADSTQQPCDE 435

  Fly   672 TQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVNQEQQT----VGSIKMHVYASY 732
            .|.              .::||::..:|.|.:           |:.::.    :|:...|    :
Zfish   436 CQE--------------KQNDSDEKRDHYHFR-----------NEFREACWLYLGAFGWH----W 471

  Fly   733 IKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPIN 797
            :......:|....:||         ..|..|..|                       ..:...:.
Zfish   472 VSVCSLVYLSVCAVSL---------AQDGVLCMW-----------------------TGEAKEVQ 504

  Fly   798 ATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMC--LRISLHLHDRLFRGI 860
            ..|.:          ..:|...:..|| :|| .|..:|:....:...|  |:.|..||..|...:
Zfish   505 GLDGW----------KELRNSRLSAYA-LLG-LLQAFLVCCAAYCLTCGSLKASRTLHTELLSDV 557

  Fly   861 TRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAI 925
            ....::....|:. :::...::|::.:|.:||..|...|..::||...:.:::     .:||...
Zfish   558 LHLPVHSQKMNTR-KLMQALTQDMQVIDEELPKHLHSILKSLLDVLSTITLIS-----FIIPVFS 616

  Fly   926 IGVILGMIRYLYVNT--SRSVKRLESISRSPVFSLTNQTFQGLTTIRALQ-AQSALEQEFH---- 983
            :.|...:|..|::.:  |.:..::.::..:|..|||       :..|..| |:::|....|
Zfish   617 LAVCPMIILLLHIQSRISSTHMQIRNMEANPAVSLT-------SLARVTQCAEASLSGPEHRAVC 674

  Fly   984 --------------EYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDV 1034
                          :|...||.:|.:         ||.|.:..:.:..|  |.:||:.:.:||.|
Zfish   675 LKHCLQAFTQNLLLKYNTINTESWVV---------LWFDGVAGIVLLLV--SLILLQTQPESGLV 728

  Fly  1035 GLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIE 1099
            .|.::.|..:.....:..:..:.:...|.|::.:.:..:...||  |....::|..:||..|.::
Zfish   729 ALTLICSFNIKEALHYCPQAASVITTDMLSLQNLFDSAKAEKEA--EWTVNYRPPYDWPQHGEVK 791

  Fly  1100 FINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIE 1163
            |.|::...|....|.|:.::.||...||||:|.|.......:|.|:|| :....|.:.||:::|.
Zfish   792 FRNYESEASSDGTPALRGVHLTILKGEKIGVVSRQKTDTDVLINSLFRSVEARSGALLIDNINIS 856

  Fly  1164 HIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMY 1228
            .:||||||.::.||.|.||||||.||.||||..|.||.::|.||....|:..|..:...|...:.
Zfish   857 RMGLHDLRGRLQIISQVPVLFSGPLRANLDPFAEHSDAQVWLALELCHLKESVQQMPAQLLHPVQ 921

  Fly  1229 DGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLH 1293
            .....||.|||:|:|||||:|...:||:::|...:|||||:.|:||.|.::|..||||.::....
Zfish   922 RTALAFSFGQRRLLCLARALLARVRILLVEEPLHHVDPETEDLLQQVIHAEFKDCTVLFLSQNPL 986

  Fly  1294 TVMDSDRVLVMDAGEVRELGHPYELLQR 1321
            :|:.:|||||:|.|:..:...|..|||:
Zfish   987 SVLHTDRVLVLDKGQAVKFDAPSTLLQQ 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	263/1328 (20%)
		ABC_membrane	94..360	CDD:294371	62/277 (22%)
		ABCC_MRP_domain1	448..650	CDD:213217	11/201 (5%)
		ABC_membrane	821..1046	CDD:294371	52/247 (21%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	89/219 (41%)
abcc13	XP_017209479.1	SunT	29..>409	CDD:331423	89/577 (15%)
abcc13	XP_017209479.1	SunT	<461..1018	CDD:331423	163/628 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840