DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and cftr

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001038348.1 Gene:cftr / 559080 ZFINID:ZDB-GENE-050517-20 Length:1485 Species:Danio rerio


Alignment Length:1513 Identity:405/1513 - (26%)
Similarity:704/1513 - (46%) Gaps:267/1513 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELK--RSN 74
            ::|...||..|::.|||...:.::|.:..|...::||......::.:..:..:.|:.|:.  :..
Zfish     3 RSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGKKK 67

  Fly    75 PSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVI 139
            ||::|.:.|.|.|.|:..|....|.|. .|::.|..||.::..|.........| .|..|.|:.:
Zfish    68 PSLLRAMARCYIKPFLLFGFLLYIGEA-TKTVQPQLLGRIIASFDPAHEPERAN-GYFLAFGLGL 130

  Fly   140 CMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVA 204
            ......:...|.:|.:..:|.::|:||..:||:|.|::|....:....|:.::::|.:||:||.:
Zfish   131 LFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFDQS 195

  Fly   205 LCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRV 269
            |...|..|..|::.||...|::..|.:::...::.:.....|||:.:.|...|:......|:.|:
Zfish   196 LGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKVLLTNKRL 260

  Fly   270 KLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSY 334
            .|.:||::.:..:|.|.||:....:|..:|..|||..|....:..........|.:.|.:|....
Zfish   261 ALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSSAYFFSAIFVIVAAVVP 325

  Fly   335 VYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEA 399
            ..|...:..::::|..||..:|..::....|.||....:.:....:.::||              
Zfish   326 HALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRLIWKIEEFL-------------- 376

  Fly   400 NQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWD------ 458
                       ||::                   .:|.:||...|:  :.|::|:||||      
Zfish   377 -----------SKEE-------------------YKLMEYDLSITE--LELQDVTASWDEGPGEL 409

  Fly   459 --------TSDGHAN-------------CAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEV 502
                    .::||.|             ..::|.|..:|...:.||.|.:|:||||.|..:|||:
Zfish   410 LERIKQENKANGHHNGDAGLFFTNLYVAPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGEL 474

  Fly   503 GIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTV 567
            ....|:....|:|||:||.:|:..|||||||:|...|:|.|||.|||.|.||.|:..||..|.|.
Zfish   475 VPSSGKIRHSGRISYSSQTAWIMPGTIRDNILFGLTYDEYRYKSVVKACQLEEDLAALPEKDKTP 539

  Fly   568 VGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTH 632
            :.|.|::|||||||||:|||||||.||:||||.|.:.:|....|.|||:|:...:::|.|||||:
Zfish   540 MAEGGLNLSGGQKARVALARAVYRDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTN 604

  Fly   633 QVQYLFDVEHLLLMGSGKIMAQGSYQELQ--------------------RSRQFQFLEQTQH--- 674
            ::::|...:.:||:.:|:....|::.|||                    ..|:...|.:|.|   
Zfish   605 KIEHLKRADKILLLHNGESFFYGTFPELQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVS 669

  Fly   675 ----------------------------------------------------------------- 674
                                                                             
Zfish   670 VDESAGMQPERSAFRQVPPTKPMYIDERKASVIVNPLGVARKASFIQVPEEEVRRTLPDRKFSLV 734

  Fly   675 ------DES--GIDTH-------------SVSSYLSRSDSEKSMEHQHNQLLR------------ 706
                  |||  |.|.:             ||.::::.:..:...||..:...|            
Zfish   735 PENELVDESFMGSDVYHNHGVHMAGQRRQSVLAFMTNAQGQGRREHLQSSFRRRLSVVPQSELAS 799

  Fly   707 --------------------PDEHVE-----DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVI 746
                                .:|::|     ::::.::|..:.|.:.|..|:.  ::..||.::|
Zfish   800 ELDIYTRRLSDSTYDMTGILEEENIEACLTDEIDEIEETFETTKWNTYVRYVS--NNKSLLYVLI 862

  Fly   747 SLFVCARIMLTG--VDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDP---YIAPL 806
            .:...|.|.:.|  ...||....:|.|: .......:...::.:.:..|..|..|..   ||   
Zfish   863 FILFIAAIEIAGSVAGIFLITDELWREE-HQRSEPNMTKHSNASSSGQTYAITVTPTSSYYI--- 923

  Fly   807 LASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTN 871
                        |.::.|| ..:.|.:...|...|....:.||..||.::...:..|.|...||.
Zfish   924 ------------LYIYVAT-SESLLAMGFFRGLPFVHTTITISKKLHQKMLHAVLSAPMSVLNTM 975

  Fly   872 SSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYL 936
            .:|||:|||:||:.|:|..||..:.|.:...:.|.|.:::|:|...::.:.|..:.:|..::|..
Zfish   976 KTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGCILVVSIVRPYIFLAATPLAIIFIVMRKY 1040

  Fly   937 YVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTR 1001
            ::.|.:.:|:||:.:|||:||....:.:||.||||.:.|:..|..||:..||:|:.|||:||..|
Zfish  1041 FLRTGQQLKQLETEARSPIFSHLIMSLKGLWTIRAFERQAYFEALFHKTLNTHTATWFLYLSTLR 1105

  Fly  1002 AFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVE 1066
            .|...:|:|.:.:.|...: ..:..::...|::|:.|..:..:.|..||.:..:..::..|.||:
Zfish  1106 WFLFRADILFVFFFTLAAW-IAVGTNQDKPGEIGIIICLAMLILGTFQWCVATSIAVDGMMRSVD 1169

  Fly  1067 RVLEYTEQPSEALLETPEKFKPK--------------SEWPSKGRIEFINFKLRYSPKEAPVLKD 1117
            ||.::.:.||    |||:..|.|              |.||.:|:||..|..::|:.....|||:
Zfish  1170 RVFKFIDLPS----ETPKPDKGKDSDLIIENVDAQADSSWPHRGQIEVRNLTVKYTEAGHAVLKN 1230

  Fly  1118 LNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPV 1182
            |:|:.|.|:::||:||||:||||:..::.:|...:|.|.||.|:...:.|...|....::||...
Zfish  1231 LSFSAEGRQRVGILGRTGSGKSSLFNALLKLVYTDGEISIDGVNWNKMPLQKWRKAFGVVPQKVF 1295

  Fly  1183 LFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARA 1247
            :|:|.||.||||....||||:|:...:|.|::.:......|:.::..||...|.|.:||:||||:
Zfish  1296 IFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVIEQFPDKLDFQLEYGGYVLSNGHKQLICLARS 1360

  Fly  1248 ILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVREL 1312
            ||...:||::||.:|::||.|.|::::|:|..|:.||:|...|::..:::....|:||.|:|:..
Zfish  1361 ILSGARILLLDEPSAHLDPVTIKVLKKTLRQSFSTCTILLSEHKVEPLLECQSFLMMDKGQVKTY 1425

  Fly  1313 GHPYELLQRTGGYLRQLV 1330
            ....:||..| .:|:|.:
Zfish  1426 DSIQKLLNET-SHLKQAI 1442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 405/1513 (27%)
ABC_membrane 94..360 CDD:294371 64/265 (24%)
ABCC_MRP_domain1 448..650 CDD:213217 96/228 (42%)
ABC_membrane 821..1046 CDD:294371 68/224 (30%)
ABCC_MRP_domain2 1096..1315 CDD:213211 81/218 (37%)
cftrNP_001038348.1 AAA 1..1485 CDD:333001 405/1513 (27%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 653..826 15/172 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1485
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1483..1485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586109
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.850

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