DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC1

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_016878726.1	Gene:	ABCC1 / 4363	HGNCID:	51	Length:	1549	Species:	Homo sapiens

Alignment Length:	1412	Identity:	486/1412 - (34%)
Similarity:	723/1412 - (51%)	Gaps:	203/1412 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDEL-------- 70
            |.:.|:|.|:.:|||:..|..||.:.||...:|:...|...||:|.....:.|:.|.
Human   227 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 291

  Fly    71 ---------------------------------KRSNPSVVRMILRAYGKIFVPMGLAFSISETI 102
                                             |..|||:.:::.:.:|..|: |...|.....:
Human   292 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL-MSFFFKAIHDL 355

  Fly   103 CKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALS 167
            .....|..|..|:.:  .|.|...:...|.|.:.:.:...:..:..|.:....|..|.:::.|:.
Human   356 MMFSGPQILKLLIKF--VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVI 418

  Fly   168 GLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGIS 232
            |.:|||.|.::.|:......|..:|::|.|..||.....:::..|..|::.||..:|::..:|.|
Human   419 GAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPS 483

  Fly   233 AVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAE 297
            .:.||:.|:..:|:.|..|.|...|:....:..|.|:||||||:.||:|:|:||||.:|...:..
Human   484 VLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLA 548

  Fly   298 VRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSY-VYL----GDPLTAQKVYTVSSYFNMLN 357
            :|.:|:|.::.:||:.|....|.:.:|..|  |||:: ||:    .:.|.||..:...:.||:|.
Human   549 IRQEELKVLKKSAYLSAVGTFTWVCTPFLV--ALCTFAVYVTIDENNILDAQTAFVSLALFNILR 611

  Fly   358 DSMVTFWPMSITFIAEALVSAKRCKDFL----LDGDKAEVPINLEANQQTGKNKRKISKKDKQKN 418
            ..: ...||.|:.|.:|.||.||.:.||    |:.|..|                       ::.
Human   612 FPL-NILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-----------------------RRP 652

  Fly   419 VELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAV 483
            |:..|...|                    :.::|.:.:|..||..   .:...:..|.:..|.||
Human   653 VKDGGGTNS--------------------ITVRNATFTWARSDPP---TLNGITFSIPEGALVAV 694

  Fly   484 VGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVV 548
            ||.||.||||.|:.||.|:...:|...:.|.::|..|::|:...::|:||:|.....|..|:.|:
Human   695 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVI 759

  Fly   549 KVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHI 613
            :.|.|..|:|:||.||.|.:||:||:||||||.|||||||||..|||||.||||||||.||||||
Human   760 QACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHI 824

  Fly   614 FDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL--------QRSRQFQF 668
            |:..|  :..|.||.||||||.:.||..|:.:::|..|||...||||||        :..|.:..
Human   825 FENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS 889

  Fly   669 LEQTQH-DESGID------------------THSVSSYLSRSDSEKS-----MEHQHN---QLLR 706
            .||.|. :|:|:.                  |.|....|.|..|..|     :...||   :|.:
Human   890 TEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 954

  Fly   707 PDEHVED----VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWV 767
            .:...|:    :..::...|.:|:.||..|:||: ..|:..:.|.||:|..:.....:|:||.|
Human   955 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAI-GLFISFLSIFLFMCNHVSALASNYWLSLW- 1017

  Fly   768 IWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLI 832
                             ||..|.|.|                       ||......::.||..|
Human  1018 -----------------TDDPIVNGT-----------------------QEHTKVRLSVYGALGI 1042

  Fly   833 VYLIRTFGFFKMCLRI-----SLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLP 892
            ...|..|| :.|.:.|     |..||..|...|.|:.|.||....||.::|||||::.|||:.:|
Human  1043 SQGIAVFG-YSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP 1106

  Fly   893 HTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFS 957
            ..:...:..:.:|.|..|::.:|.....|....:|:|...::..||.:||.:|||||:|||||:|
Human  1107 EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYS 1171

  Fly   958 LTNQTFQGLTTIRALQAQSALEQEFHEYQ---NTNTSAWFLFLSCTRAFALWSDVL--CIVYMTA 1017
            ..|:|..|::.|||.:.|   |:..|:..   :.|..|::..:...|..|:..:.:  |||...|
Human  1172 HFNETLLGVSVIRAFEEQ---ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAA 1233

  Fly  1018 VTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLET 1082
            : |: ::.:....:|.|||::.:|..:|....|.:|.::|:|..:.:|||:.||:|...||..:.
Human  1234 L-FA-VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1296

  Fly  1083 PEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR 1147
            .|. .|.|.||..||:||.|:.|||......||:.:|.||...||:||||||||||||:...:||
Human  1297 QET-APPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1360

  Fly  1148 L-ACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVE 1211
            : ...||.|.||.::|..|||||||.:::|||||||||||:||.||||..:.||||:|.:|....
Human  1361 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAH 1425

  Fly  1212 LRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTI 1276
            |:.:||.|...|:....:||.|.|||||||||||||:||..|||::|||||.||.|||.|||.||
Human  1426 LKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTI 1490

  Fly  1277 RSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323
            |::|..||||||||||:|:||..||:|:|.||::|.|.|.:|||:.|
Human  1491 RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	486/1412 (34%)
		ABC_membrane	94..360	CDD:294371	76/270 (28%)
		ABCC_MRP_domain1	448..650	CDD:213217	94/203 (46%)
		ABC_membrane	821..1046	CDD:294371	73/234 (31%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	129/219 (59%)
ABCC1	XP_016878726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660