Protein Alignment rdog and Cftr

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1462
• Identity: 555/1462 - (37%)
• Similarity: 812/1462 - (55%)
• Gaps: 208/1462 - (14%)

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSN-- 74
            |||...||..||..|.|...|..||.:..|..::|.|..|...||::.::..:.|..||:||:
  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74

  Fly    75 ---PSVVRMILRAY-------G---------KIFVPMGLA---------------------FSIS 99
               |.:...:.|.:       |         |..:|..||                     .|||
  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISIS 139

  Fly   100 ETICK-----------------------SLMPLFL---GGL---------VGYFAT------NQT 123
            :::.:                       :|.|..|   |.|         |.:.||      :||
  Fly   140 DSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQT 204

  Fly   124 ------DISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSS 182
                  |::...|.|....:..|.|:..:.....:     :|.::|:|...|||||.|::|..::
  Fly   205 VEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRL-----MGARMRIACCSLIYRKTLRLSMKTA 264

  Fly   183 NDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIG-VSFMLSFIPL 246
            .....|..||:||||:.|.|....|:|..|..|::::|..:|::..|||.|::| |..:|..:|:
  Fly   265 GQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPV 329

  Fly   247 QAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAY 311
            |...:|..:..|...|||||.||.:|||::|||||||||||||.|..|:||.|..|:|.||..:|
  Fly   330 QTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASY 394

  Fly   312 IHAALGCTSMISPLS-VFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEAL 375
            :......|.:.:..| :::.|.:...:|..:||..|::.:||:|:|......::|::::|.||||
  Fly   395 LRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEAL 459

  Fly   376 VSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYD 440
            ||.:|.:|||:          ||     |:.:|                  :.|..|.   ||.:
  Fly   460 VSLRRIQDFLM----------LE-----GREER------------------TQGLTHK---RDQE 488

  Fly   441 PEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGID 505
             ....:.|.:|:::||||......  .::..:..|:...|.||:|||||||||.|.:||||:.:.
  Fly   489 -GGDSRAVTIKDINASWDIEKPQK--TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVI 550

  Fly   506 KGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGE 570
            .|...:.|.:|||:||.|:|.|::|:||:|.|:::.:||::|.:.|.|..|.:.||.||.|:|||
  Fly   551 DGGVFIQGDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGE 615

  Fly   571 RGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCI--RDFLS--NKIRILVT 631
            ||.||||||:||:|||||||:.|.|||:||||||||.|||:|:||..|  |..|:  ...|||||
  Fly   616 RGASLSGGQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVT 680

  Fly   632 HQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS-RQF-QFLEQTQHDESGIDTHSVSSYLS----R 690
            |||.:|.:.:.::::..|:|:.||:||||..| ..| :.||:.:.:|.|.::.:.:|.||    .
  Fly   681 HQVHFLSEADVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLE 745

  Fly   691 SDSE-----KSMEHQHNQLLRP---------------DEHV-EDVNQEQQTVGSIKMHVYASYIK 734
            ||.|     ..::..:.||.:.               |::| ||...|.|..|.|...|:..|..
  Fly   746 SDDEDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFH 810

  Fly   735 ALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINAT 799
            |..:......::.:.|.::::.:..|:|.:.|...|.|.:....|.      :|.
  Fly   811 AGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATF------STF---------- 859

  Fly   800 DPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRAS 864
                              |.:..|..::.|.:|:...|.|.|||:|:..|..||||:|..|..|:
  Fly   860 ------------------ECMYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHAT 906

  Fly   865 MYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVI 929
            |.||:|..|||||||||||:..:|..||..::|.:...:.:.|::|::.|.|..|:....::.|:
  Fly   907 MRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVV 971

  Fly   930 LGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWF 994
            ..:|..||:..|:.:||||.|.||||||..:.:..||..||:.|.|..:.:||...|:.::|.|.
  Fly   972 DVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQ 1036

  Fly   995 LFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELE 1059
            |.::......||.|.:..:::|:|||||::..:...||:|||||..:..:|||.|:|:||.||..
  Fly  1037 LTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESL 1101

  Fly  1060 NQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEP 1124
            .|||||||||:|||...|..|  .|| .|..:||::|::||.|...||.|..:|||::||.|||.
  Fly  1102 QQMTSVERVLQYTELEQEPAL--GEK-TPPQQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEA 1163

  Fly  1125 REKIGIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLR 1189
            ..|:||||||||||||:|.::||||..||.|.||.::...|.|..||:::|||||||||||.|:|
  Fly  1164 GWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIR 1228

  Fly  1190 YNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKI 1254
            |||||.:..:|.|:|.||.|||||.    .|.||:..:.:.|.|||||||||:||||||||:||:
  Fly  1229 YNLDPFERYTDAELWSALEDVELRK----AIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKV 1289

  Fly  1255 LIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELL 1319
            |::|||||||||:||.|||:|||.||..|||||:||||||||||||::|||||...|...||.||
  Fly  1290 LVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLL 1354

  Fly  1320 QRTGGYLRQLVDNTGAATSFALQQAAEQSYSK 1351
            :::.|:|||:|:.|| ..|.||::.|..|:.:
  Fly  1355 KKSQGHLRQMVEATG-GESEALKKTASDSHKR 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	541/1430 (38%)
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	541/1428 (38%)