DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and CG7806

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster

Alignment Length:	1358	Identity:	417/1358 - (30%)
Similarity:	665/1358 - (48%)	Gaps:	150/1358 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KANFFSQWSFWWMRDLFKRGLQGPLTD-EELYQHRKTLDSERVTNKF-------AELWEDELKRS 73
            :||..|::.|.|::.|..:|:.|.|.. |:|:.....|:..|::.|.       ..||
  Fly   229 EANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLHLALSQSQSLW------- 286

  Fly    74 NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIV 138
                 |.:.|.:|..|..:|:...|:: :.....||.||||:     .|.....|..|.||:|:.
  Fly   287 -----RALHRCFGVEFYLIGILRLIAD-LSGFAGPLLLGGLL-----RQDHADPNQVYYYALGLF 340

  Fly   139 ICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVS--KSSSNDGLRGRAINILSNDLGRF 201
            ...|:..:....|.:.:..|..|:|:.:...||||.|:..  |.|..|     .:|::|.|..|.
  Fly   341 GSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGLKESKPD-----LLNLMSTDTDRI 400

  Fly   202 DVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQ--MTAER 264
            ..:....|..|..|.:.....:|:|.::|.:.:.||.|....||:..|.||:...:..  |||:
  Fly   401 VNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAK- 464

  Fly   265 TDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFL 329
             |.|:....|.:||.:.||:.|||..|...|..:|.:|::.:....|:.|.  |....:...|.:
  Fly   465 -DARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAM--CVYFWATTPVLM 526

  Fly   330 ALCSY---VYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKA 391
            .|.::   |.:|:||.|...||..:...||...:..| |..:..:.||.||.||.:..:
  Fly   527 CLLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAF-PWVLNGLIEAWVSIKRVQQLM------ 584

  Fly   392 EVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSAS 456
            :|| ||:.:              ...|..:.||..|..       .|..|....|..||:...||
  Fly   585 DVP-NLDYS--------------SYYNPIMRGSGGSGA-------GDDAPLDAPKASVLQMKCAS 627

  Fly   457 W----DTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVH---GK 514
            :    |.........::|.:.|||...|..:.||||.||||||:.::..:....||..|.   ..
  Fly   628 FCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTG 692

  Fly   515 ISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQ 579
            ..|..|..|:..||||||||:...::|:.||.|:..|.||.|:::| .|||..|||.|.:|||||
  Fly   693 FGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQ 756

  Fly   580 KARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLL 644
            :|||:||||||:...:|||||.||::|.||.:||...||...|.:|.||:||..:|..|....:|
  Fly   757 RARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQIL 821

  Fly   645 LMGSGKIM-AQGSYQELQRSRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPD 708
            .:..|::: ::...|.::.|     |::...||........|..||....:||::   :.||
  Fly   822 QVKDGQLLPSEYMTQSIELS-----LDEDADDEQEPTVRRRSVELSNQYDKKSLD---SLLL--- 875

  Fly   709 EHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQI 773
                   :|.:..|.:..:|:..|.||:.|.....:::|: |..::.....|.:|:.||
  Fly   876 -------EELREYGHLSGNVFTCYWKAVTSPLAFTVLLSV-VLMQLTRNLSDAWLAYWV------ 926

  Fly   774 AVNRTTTLLNETDTTI---ANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLI--- 832
                       |:||:   .|||   :.....:.|.:.::.::|   ....||.:|..|..:
  Fly   927 -----------TETTLDPHKNDT---SLDHILMRPTVGNETESG---HTTKFYLSIFTAIAVSNS 974

  Fly   833 -VYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLL 896
             |.|.|.|.|....::.::.:|::|.:.:..|...||:..|.||||||||.|..|||..||..|.
  Fly   975 LVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILN 1039

  Fly   897 DCLAFIIDVSGVVIIVAIANYWL-LIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTN 960
            ..||.:..:.|.:.:...|..|| |:...::.:.|. ::..|.:.||.:|||.|.:.||:::...
  Fly  1040 ILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLS-LQQRYRHASRDIKRLSSNAMSPLYTHFT 1103

  Fly   961 QTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIV------YMTAVT 1019
            :|.|||||||:::|....:::|......:..|.....:..:..||...:|..:      .:.|:|
  Fly  1104 ETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAIT 1168

  Fly  1020 FSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPE 1084
            .|...     :.|.|||.|.::.::||.....:...||.|.::.:|||:.:|.:...|.  ....
  Fly  1169 ASHTT-----NPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQ--NASG 1226

  Fly  1085 KFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA 1149
            ..:|...||::|.:.|...:|.|....||.|:.:.|..|..|:|||||||||||:|::.::.|:|
  Fly  1227 SAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVA 1291

  Fly  1150 -CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELR 1213
             ...|.||:|.|:::.:.|..||.::.:|.|:|.||.||:|.||||.....|.|:|.|:.:....
  Fly  1292 PLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAA 1356

  Fly  1214 SYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRS 1278
            :.:...:|||:.::...|:|.|.|||||:|||||:|::.|::.:||.|:|:|.|:|..|||.:|:
  Fly  1357 TLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRN 1421

  Fly  1279 KFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRT-----GGYLRQLVD 1331
            .|..||:|.|||||..:...||::|:|.|.:.|.|:|..|...:     |..|.|.:|
  Fly  1422 AFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQDID 1479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	417/1358 (31%)
		ABC_membrane	94..360	CDD:294371	75/272 (28%)
		ABCC_MRP_domain1	448..650	CDD:213217	87/208 (42%)
		ABC_membrane	821..1046	CDD:294371	69/235 (29%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	93/219 (42%)
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	413/1349 (31%)
		ABC_membrane	328..560	CDD:294371	67/240 (28%)
		ABCC_MRP_domain1	621..827	CDD:213217	86/206 (42%)
		ABC_membrane	948..1192	CDD:279056	72/252 (29%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	93/219 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I4365
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.870