DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcb5

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_006240775.1	Gene:	Abcb5 / 314537	RGDID:	1566342	Length:	1255	Species:	Rattus norvegicus

Alignment Length:	1397	Identity:	296/1397 - (21%)
Similarity:	553/1397 - (39%)	Gaps:	274/1397 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SERV------TNKFAELWEDELKRSNPSVVRMILRAYGK----IFVPMGLAFSISETICKSLMPL 109
            |||.      ..::..|.|...|..|.:|..:.:..:..    :.:.:|:..|:.......||.|
  Rat     4 SERANGLQESNQRYGSLQEQLPKAGNQAVGPIEIFRFADNLDIVLMTLGILASMINGATVPLMSL 68

  Fly   110 FLGGLVGYF------ATNQT--------------DISENTAYLYAMGIVICMLVPVITFHPFIFY 154
            .||.:..:|      .||:|              ||...|  ||.:||....|  |:.:....|:
  Rat    69 VLGEISDHFINGCLVQTNKTKYQNCSQSQEKLNEDIIMLT--LYYVGIGAAAL--VLGYVQISFW 129

  Fly   155 IFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFD-VALCFLHDTWKGPMES 218
            :....            |:..::.|...:        :||:.|:..|| ..:|.|:....|.:..
  Rat   130 VITAA------------RQTTRIRKQFFH--------SILAQDISWFDGTDICELNTRMNGDISK 174

  Fly   219 ILIGF-----LMYREI-GISAVIGVSF---------MLSFIPL-QAWAAKKAAYYRQMTAERTDM 267
            :..|.     ||::.| |.|..:.:|.         :||..|| .|.:|..:.....:|::..|.
  Rat   175 LCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLAILSTSPLIMAASALCSRMVISLTSKELDA 239

  Fly   268 RVK---LMNEIIQGIQVIKMY-AWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVF 328
            ..|   :..|.:..|:.:..: |.||...|....::..:...|:.......:||........:..
  Rat   240 YSKAGAVAEEALSSIRTVTAFGAQEKEIQRYTQNLKDAKDAGIKRAIASKLSLGAVYFFMNGAYG 304

  Fly   329 LAL---CSYVYLGDPLTAQKVYTVSS----YFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLL 386
            ||.   .|.::.|:|     .|||.:    :|::::.|      ..|..:|..|      :.|.:
  Rat   305 LAFWYGTSLIFGGEP-----GYTVGTILAVFFSVIHSS------YCIGSVAPHL------ETFTI 352

  Fly   387 DGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLK 451
            ....|   .|:         ...|.||....|....|               |.||:.:..:..|
  Rat   353 ARGAA---FNI---------FHVIDKKPNIDNFSTAG---------------YKPESIEGNIEFK 390

  Fly   452 NVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLL-------GEVGIDKGEA 509
            |||.|:.:.....  .::.|:..||.....|:|||.|:||::.:.:|.       |.:.:|:.:.
  Rat   391 NVSFSYPSRPSAK--ILKGFNLKIKSGETVALVGPSGSGKTTTVQLLQRLYDPEEGCITVDENDI 453

  Fly   510 MVHG------KISYASQESWVFEGTIRDNIVF-VEDYNERRYKKVVKVCGLERDMELLPRGDLTV 567
            ....      :|...|||..:|..||.:||.| .|..:|...::..:.......:...|:...|:
  Rat   454 RTQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVSEEEMEQAAREANAYDFIMAFPKKFNTL 518

  Fly   568 VGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTH 632
            |||:|..:|||||.|:::|||:.|...|.:||:..||:||. .:.:....:......:..::|.|
  Rat   519 VGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTE-SESLVQAALEKASKGRTTLVVAH 582

  Fly   633 QVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFLEQTQHDESGIDTHSVSSYLSRS-DSEKS 696
            ::..:...:.::.|..|:::.:|.:.||...:...:......|...:|....|...|.: ::...
  Rat   583 RLSTIRGADLIVTMKDGEVVEKGIHAELMAKQGLYYSLAVAQDIKKVDEQMESRTCSAAGNASNG 647

  Fly   697 MEHQHNQLLRP--DEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGV 759
            .....|....|  |:..|.|..::.|:..:.:.......|:.....:||.:.|.
  Rat   648 SLCNVNSAKSPCTDQFEEAVPHQKTTLPEVSLLKIFKLSKSEWPFVVLGTLASA----------- 701

  Fly   760 DYFLSRWVIWEEQIAVNRTTTLLNETD-TTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFY 823
               |:..|.....|...:..|:..:.: ||:..|.                        ||....
  Rat   702 ---LNGSVHPAFSIIFGKLVTMFEDKNKTTLKQDA------------------------ELYSMM 739

  Fly   824 ATILG-ATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFN--TNSSGRILNRFSKDIR 885
            ..:|| ..|:.||::...:.:....:::.|....|:.:....|.:::  .||:|.:....:.|:.
  Rat   740 LVVLGIVALVTYLMQGLFYGRAEEILAMRLRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVA 804

  Fly   886 TVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYW----LLIPAAIIGVILGMIRYL----YVNTSR 942
            .: .....:.|..:...:....:.|:::....|    |::..|.|..:.|||:..    :.|..:
  Rat   805 QI-RGAATSRLGIITQDVTNMSLSILISFVYGWEMTLLILSFAPILAVTGMIQTAAMAGFANKDK 868

  Fly   943 -SVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTN----------------T 990
             .:||...|:...|        :.:.|:.:|..:.|.|..:.|...|.                .
  Rat   869 QELKRAGKIATEAV--------ENIRTVVSLTREKAFEHMYEETLRTQHRNALKRAHITGSCYAV 925

  Fly   991 SAWFLFLSCTRAFALWSDVL---------CIVYMTAVTFSFLLLKD------EFDSGDVGLAILH 1040
            |..|:..:....|...:.::         ..:..||:.:..:.:.:      |:.....|.|.|.
  Rat   926 SHAFVHFAHAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGAAHLF 990

  Fly  1041 STTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKL 1105
                           |.|:|: .|::...:..|:|...                :|.:||.....
  Rat   991 ---------------ALLKNK-PSIDSCSQNGEKPDAC----------------EGNLEFREVSF 1023

  Fly  1106 RYSPK-EAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRL-ACNEGMIRIDDVDIEHIGLH 1168
            .|..: |.|||:|::.:||..:.:..||.:|.|||:.:|.:.|. ...:|.:.:|.||::.:.:.
  Rat  1024 FYPCRPEVPVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQ 1088

  Fly  1169 DLRSQVSIIPQDPVLFSGTLRYNLDPMDERSD---EEMWKALGDVELRSYVSTLIGGLNCRMYDG 1230
            .||||.:|:.|:||||:.::..|:...|....   ||:.:......:.|::..|.|..:.::...
  Rat  1089 WLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPGKYSTQVGLR 1153

  Fly  1231 GSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTV 1295
            |.:.|.||:|.:.:|||:||..|||::||||:.:|.|::|::||.:.......|.|.:||||.|:
  Rat  1154 GMHLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKMVQQALDKARRGRTCLVVAHRLSTI 1218

  Fly  1296 MDSDRVLVMDAGEVRELGHPYELLQRTGGYLR 1327
            .::|.::|:..|.::|.|...|||:....|.:
  Rat  1219 QNADMIVVLQNGRIKEQGTHQELLRNGETYFK 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	296/1397 (21%)
		ABC_membrane	94..360	CDD:294371	64/313 (20%)
		ABCC_MRP_domain1	448..650	CDD:213217	56/215 (26%)
		ABC_membrane	821..1046	CDD:294371	41/267 (15%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	74/223 (33%)
Abcb5	XP_006240775.1	PTZ00265	48..1252	CDD:240339	288/1353 (21%)
		ABC_membrane	53..334	CDD:279056	64/309 (21%)
		ABC_MTABC3_MDL1_MDL2	387..624	CDD:213216	60/239 (25%)
		ABC_membrane	697..963	CDD:279056	47/312 (15%)
		ABC_MTABC3_MDL1_MDL2	1017..1254	CDD:213216	77/234 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000