Protein Alignment rdog and Abcc8

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_037171.2
• Gene: Abcc8 / 25559
• RGDID: 3786
• Length: 1582
• Species: Rattus norvegicus
• Alignment Length: 1472
• Identity: 434/1472 - (29%)
• Similarity: 718/1472 - (48%)
• Gaps: 254/1472 - (17%)

  Fly     3 RTRRKVVRPKN----------PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSER 57
            :|.|:|..|::          ||  .|..|:.::|||....|..            |:|.:|...
  Rat   199 KTPREVKPPEDLQDLGVRFLQPF--VNLLSKGTYWWMNAFIKTA------------HKKPIDLRA 249

  Fly    58 V----------TN--KFAELWEDELKRSNPS------VVRMILRAYGKIFVPMGLAFSISETICK 104
            :          ||  :....::.:.::...|      :.|.:..|:|:..| :...|.|...:..
  Rat   250 IGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQGARAIWRALCHAFGRRLV-LSSTFRILADLLG 313

  Fly   105 SLMPLFLGGLVG------------------YFATNQTDISENTAYLYAMGIVICMLVPVITFHPF 151
            ...||.:.|:|.                  ||.::|..:  ..||:.|:.:.:.:|:. .||...
  Rat   314 FAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFL--GNAYVLAVLLFLALLLQ-RTFLQA 375

  Fly   152 IFYI-FQVGTKLRLALSGLIYRKVLQVSKSSSNDG--LRGRAINILSNDLGRFDVALCFLHDTWK 213
            .:|: .:.|..||.|:...||.|::.:|.|:.:.|  ..|:..|:::.|..:.........:.|.
  Rat   376 SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWA 440

  Fly   214 GPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQG 278
            .|::.|:...|:|..:|:||:||.:.::...|:|.:.|.|.:..::.|.|.::.|:|..||:::|
  Rat   441 MPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRG 505

  Fly   279 IQVIKMYAWEKSFARVIAEVRLKEVKAIRGTA-------YIHAALGCTSMI-------------- 322
            |:::|:||||..|...:.:.|.||:.::|..|       :::.|:...:::
  Rat   506 IKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESD 570

  Fly   323 -SPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLL 386
             ||...|.:|..:..|..||     :.:||.               :....:||||.::..:||.
  Rat   571 FSPSVAFASLSLFHILVTPL-----FLLSSV---------------VRSTVKALVSVQKLSEFLS 615

  Fly   387 DGDKAE---VPINLEANQQTGK---------NKRKISKKDKQKNVELNGSLLSNGQVHHNRLR-D 438
            ..:..|   .|.......|.||         |:::.::::.:   :|.|.|        .||. .
  Rat   616 SAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVR---DLLGPL--------QRLTPS 669

  Fly   439 YDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEV- 502
            .|.:|...||.:.....:| |.||..  .:.:.:..|....|..:||.||.||||.|...|||:
  Rat   670 TDGDADNFCVQIIGGFFTW-TPDGIP--TLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQ 731

  Fly   503 ----------------GID----------KGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNE 541
                            |.|          ..:|...|.::||||:.|:...|:.:||.|...:|:
  Rat   732 KVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNK 796

  Fly   542 RRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVD 606
            :|||.|::.|.|:.|:::||.||.|.:||||::|||||:.|:|:|||:|:..::..||||.||:|
  Rat   797 QRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALD 861

  Fly   607 THVGKHIFDRCIRDFLSNKIR--ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFL 669
            .|:..|:....|.:.|.:..|  :||||::|||...:.::.|..|.|..:|:.::.||| :.|..
  Rat   862 VHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRS-ECQLF 925

  Fly   670 EQ----TQHDESGIDTHSVSSYLSRSDSE---KSMEHQHNQLLRPDEHVEDV--NQEQQTVGSIK 725
            |.    ....:..::..:|....:...|:   ::|..:...||..||..|:.  ::|...:.|:
  Rat   926 EHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSV- 989

  Fly   726 MHVYA-----SYIKALDSTFLLGIVISLFVCARIM----LTGVDYFLSRWVIWEEQIAVNRTTTL 781
            :|..|     :..|.|.|..:|  ::||.|.::::    |..:||:|::|
  Rat   990 LHQRAKIPWRACTKYLSSAGIL--LLSLLVFSQLLKHMVLVAIDYWLAKW--------------- 1037

  Fly   782 LNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVL---FYATI------LGATLIVYLIR 837
               ||:.:.            ::|...:   ..:.||..|   .||.:      ||..|.  |:.
  Rat  1038 ---TDSALV------------LSPAARN---CSLSQECALDQSVYAMVFTVLCSLGIALC--LVT 1082

  Fly   838 TFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCL--A 900
            :.......|:::..||..|...|..|.|.||.|...|.||||||.|..|:|..:|.| |:||  :
  Rat  1083 SVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRS 1146

  Fly   901 FIIDVSGVVIIVAIANYWL--LIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTF 963
            .::.||.:.:|..:...:|  |:|.|::...:.  :|..| .||.:::|:..::.|:.|...:|.
  Rat  1147 TLLCVSALAVISYVTPVFLVALLPLAVVCYFIQ--KYFRV-ASRDLQQLDDTTQLPLLSHFAETV 1208

  Fly   964 QGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV------LCIVYMTAVTFSF 1022
            :|||||||.:.::..:|:..||.::|..| .|||:....   |.:|      .|:|.:.|.|...
  Rat  1209 EGLTTIRAFRYEARFQQKLLEYTDSNNIA-SLFLTAANR---WLEVRMEYIGACVVLIAAATSIS 1269

  Fly  1023 LLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERV--LEYTEQPSEALLETPEK 1085
            ..|..|..:|.|||.:.::..::....|.:|..|::|.|:.:|:|:  |..||..|...|..|..
  Rat  1270 NSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSL 1334

  Fly  1086 FKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA- 1149
            . ||: ||.:|:|:..|..:||.....||||.:|..|.|.:||||.||||:||||...:.||:.
  Rat  1335 I-PKN-WPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVD 1397

  Fly  1150 CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRS 1214
            ..||.|.||.:||..:.||.|||::|||.|||||||||:|:||||..:.||..:|:||...:|:.
  Rat  1398 MFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKL 1462

  Fly  1215 YVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSK 1279
            .|..|.|||:..:.:||.|||.|||||.|||||.:|...|.|||||||::|..|:.::|:.:.:.
  Rat  1463 VVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTA 1527

  Fly  1280 FAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQR 1321
            ||..||:|||||:||::.:|.|:|:..|.:.|...|.:||.:
  Rat  1528 FADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQ 1569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	430/1451 (30%)
Abcc8	NP_037171.2	MRP_assoc_pro	224..1579	CDD:188098	427/1445 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..768		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..962		3/22 (14%)