Protein Alignment rdog and Abcc2

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_036965.1
• Gene: Abcc2 / 25303
• RGDID: 2366
• Length: 1541
• Species: Rattus norvegicus
• Alignment Length: 1435
• Identity: 464/1435 - (32%)
• Similarity: 738/1435 - (51%)
• Gaps: 222/1435 - (15%)

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPS 76
            :.|...|:|.|..:|.|......:|.:.|||.|:::...:...:..||:||......:|:::..:
  Rat   191 QTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQA 255

  Fly    77 VVRMILRA-------------------------------------YGKIFVPMGLAFSISETICK 104
            ..|.:.::                                     |.|.::...|..:....|.|
  Rat   256 FQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILK 320

  Fly   105 S------------LMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVIT------FHPF 151
            |            |.|..|..|:|:       :..:.:|:: .|.:..:|:..:|      ...:
  Rat   321 SFILKLIHDLLVFLNPQLLKLLIGF-------VKSSNSYVW-FGYICAILMFAVTLIQSFCLQSY 377

  Fly   152 IFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPM 216
            ..:.|.:|..:|..:...||:|.|.:|..:......|..:|::|.|..:...|..::...|...:
  Rat   378 FQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVI 442

  Fly   217 ESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQV 281
            :..|..|.::||:|.|.:.||..|:..||:....|.|....:....:..|.|:|:||||:.||::
  Rat   443 QITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKI 507

  Fly   282 IKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSYVYLGDP---LTA 343
            :|.:|||.||...:..:|.||:|.:.....:.:.|.....|:|:.|.:...|...|.|.   |.|
  Rat   508 LKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNA 572

  Fly   344 QKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKR 408
            :|.:|..:.||:|...: :..||..:.|.:|.||..|.:.: |.||
  Rat   573 EKAFTSITLFNILRFPL-SMLPMVTSSILQASVSVDRLERY-LGGD------------------- 616

  Fly   409 KISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFST 473
                       :|:.|.:       .|:.::|     |.|.....|.:||..   ....|:|.:.
  Rat   617 -----------DLDTSAI-------RRVSNFD-----KAVKFSEASFTWDPD---LEATIQDVNL 655

  Fly   474 DIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVED 538
            |||...|.||||.||:||||.::.:|||:....|...:.|..:|..|:||:..|||:|||:|..:
  Rat   656 DIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSE 720

  Fly   539 YNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLS 603
            |||::|::|:|.|.|..|:|:||.||:..:||:|::||||||.|||||||.|:.||||:||||||
  Rat   721 YNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLS 785

  Fly   604 AVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR---- 662
            |||.|||||||::.:  ...|:.|.||.|||.:.:|..|:.::::|.|.|:.:|||::|..
  Rat   786 AVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGV 850

  Fly   663 -SRQFQ-FLE--------------QTQHDESGI---------DTHSVS-----------SYLSRS 691
             :|.:: |::              :.:.|:.|:         |..|::           |..|||
  Rat   851 FARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRS 915

  Fly   692 DSE--KSMEH-----QHNQLLRPDEHVED---VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVI 746
            .|.  ||:::     ..|.|...::.||.   :.:|....|.:|..:|..|::|:....:|.|::
  Rat   916 SSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIIL 980

  Fly   747 SLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDI 811
             .:....:...|.:.:||.|....:.         ||.|:.:.::                 .|:
  Rat   981 -FYGLNNVAFIGSNLWLSAWTSDSDN---------LNGTNNSSSH-----------------RDM 1018

  Fly   812 QAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRI 876
            :.|:...|.|       |..|..||.|......|...|..||.:|...|.||.|.||:|..:|||
  Rat  1019 RIGVFGALGL-------AQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRI 1076

  Fly   877 LNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIAN---YWLLIPAAIIGVILGMIRYLYV 938
            :||||.||.|||..||.||...:.....::|.::::.:|.   ..::||.:|:.:   .::..||
  Rat  1077 VNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYI---SVQVFYV 1138

  Fly   939 NTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEF---HEYQ-NTNTSAWFLFLSC 999
            .|||.::||:|:::||::|..::|..||..|||.:.|    |.|   :|.| :.|....|.:::.
  Rat  1139 ATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQ----QRFLAWNEKQIDINQKCVFSWITS 1199

  Fly  1000 TRAFALWSDVL--CIVYMTAVTFSFLLLKDEFDSGD-VGLAILHSTTMTGMCQWGMRQTAELENQ 1061
            .|..|:..:::  .:|:.:|:   .|::..:..:|| ||..:.::..:|....|.:|.|:|.|..
  Rat  1200 NRWLAIRLELVGNLVVFCSAL---LLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAETN 1261

  Fly  1062 MTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPRE 1126
            :.:|||:.||....:||...|.:  :|.::||..|.|:|.|:::||.|:...|||.:...|:..|
  Rat  1262 IVAVERISEYINVENEAPWVTDK--RPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNIKSGE 1324

  Fly  1127 KIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRY 1190
            |:|:||||||||||:...:|| |....|.|.||.:|:..|||||||.:::||||||:||||:||.
  Rat  1325 KVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRM 1389

  Fly  1191 NLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKIL 1255
            ||||.::.||||:|:||....|||:||.|..||...:.:||.|.|:|||||:||.||:||.:|||
  Rat  1390 NLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKIL 1454

  Fly  1256 IMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQ 1320
            ::|||||.||.|||.|||.|||.:|:.|||:||||||||:||||:::|:|.|::.|.|.|.|||.
  Rat  1455 VLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLS 1519

  Fly  1321 RTGGY 1325
            ..|.:
  Rat  1520 NRGSF 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	463/1429 (32%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	464/1435 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	862..881		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..923		6/21 (29%)