DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcc2

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1435	Identity:	464/1435 - (32%)
Similarity:	738/1435 - (51%)	Gaps:	222/1435 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPS 76
            :.|...|:|.|..:|.|......:|.:.|||.|:::...:...:..||:||......:|:::..:
  Rat   191 QTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQA 255

  Fly    77 VVRMILRA-------------------------------------YGKIFVPMGLAFSISETICK 104
            ..|.:.::                                     |.|.::...|..:....|.|
  Rat   256 FQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILK 320

  Fly   105 S------------LMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVIT------FHPF 151
            |            |.|..|..|:|:       :..:.:|:: .|.:..:|:..:|      ...:
  Rat   321 SFILKLIHDLLVFLNPQLLKLLIGF-------VKSSNSYVW-FGYICAILMFAVTLIQSFCLQSY 377

  Fly   152 IFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPM 216
            ..:.|.:|..:|..:...||:|.|.:|..:......|..:|::|.|..:...|..::...|...:
  Rat   378 FQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVI 442

  Fly   217 ESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQV 281
            :..|..|.::||:|.|.:.||..|:..||:....|.|....:....:..|.|:|:||||:.||::
  Rat   443 QITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKI 507

  Fly   282 IKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSYVYLGDP---LTA 343
            :|.:|||.||...:..:|.||:|.:.....:.:.|.....|:|:.|.:...|...|.|.   |.|
  Rat   508 LKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNA 572

  Fly   344 QKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKR 408
            :|.:|..:.||:|...: :..||..:.|.:|.||..|.:.: |.||
  Rat   573 EKAFTSITLFNILRFPL-SMLPMVTSSILQASVSVDRLERY-LGGD------------------- 616

  Fly   409 KISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFST 473
                       :|:.|.:       .|:.::|     |.|.....|.:||..   ....|:|.:.
  Rat   617 -----------DLDTSAI-------RRVSNFD-----KAVKFSEASFTWDPD---LEATIQDVNL 655

  Fly   474 DIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVED 538
            |||...|.||||.||:||||.::.:|||:....|...:.|..:|..|:||:..|||:|||:|..:
  Rat   656 DIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSE 720

  Fly   539 YNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLS 603
            |||::|::|:|.|.|..|:|:||.||:..:||:|::||||||.|||||||.|:.||||:||||||
  Rat   721 YNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLS 785

  Fly   604 AVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR---- 662
            |||.|||||||::.:  ...|:.|.||.|||.:.:|..|:.::::|.|.|:.:|||::|..
  Rat   786 AVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGV 850

  Fly   663 -SRQFQ-FLE--------------QTQHDESGI---------DTHSVS-----------SYLSRS 691
             :|.:: |::              :.:.|:.|:         |..|::           |..|||
  Rat   851 FARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRS 915

  Fly   692 DSE--KSMEH-----QHNQLLRPDEHVED---VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVI 746
            .|.  ||:::     ..|.|...::.||.   :.:|....|.:|..:|..|::|:....:|.|::
  Rat   916 SSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIIL 980

  Fly   747 SLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDI 811
             .:....:...|.:.:||.|....:.         ||.|:.:.::                 .|:
  Rat   981 -FYGLNNVAFIGSNLWLSAWTSDSDN---------LNGTNNSSSH-----------------RDM 1018

  Fly   812 QAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRI 876
            :.|:...|.|       |..|..||.|......|...|..||.:|...|.||.|.||:|..:|||
  Rat  1019 RIGVFGALGL-------AQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRI 1076

  Fly   877 LNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIAN---YWLLIPAAIIGVILGMIRYLYV 938
            :||||.||.|||..||.||...:.....::|.::::.:|.   ..::||.:|:.:   .::..||
  Rat  1077 VNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYI---SVQVFYV 1138

  Fly   939 NTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEF---HEYQ-NTNTSAWFLFLSC 999
            .|||.::||:|:::||::|..::|..||..|||.:.|    |.|   :|.| :.|....|.:::.
  Rat  1139 ATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQ----QRFLAWNEKQIDINQKCVFSWITS 1199

  Fly  1000 TRAFALWSDVL--CIVYMTAVTFSFLLLKDEFDSGD-VGLAILHSTTMTGMCQWGMRQTAELENQ 1061
            .|..|:..:::  .:|:.:|:   .|::..:..:|| ||..:.::..:|....|.:|.|:|.|..
  Rat  1200 NRWLAIRLELVGNLVVFCSAL---LLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAETN 1261

  Fly  1062 MTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPRE 1126
            :.:|||:.||....:||...|.:  :|.::||..|.|:|.|:::||.|:...|||.:...|:..|
  Rat  1262 IVAVERISEYINVENEAPWVTDK--RPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNIKSGE 1324

  Fly  1127 KIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRY 1190
            |:|:||||||||||:...:|| |....|.|.||.:|:..|||||||.:::||||||:||||:||.
  Rat  1325 KVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRM 1389

  Fly  1191 NLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKIL 1255
            ||||.::.||||:|:||....|||:||.|..||...:.:||.|.|:|||||:||.||:||.:|||
  Rat  1390 NLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKIL 1454

  Fly  1256 IMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQ 1320
            ::|||||.||.|||.|||.|||.:|:.|||:||||||||:||||:::|:|.|::.|.|.|.|||.
  Rat  1455 VLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLS 1519

  Fly  1321 RTGGY 1325
            ..|.:
  Rat  1520 NRGSF 1524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	464/1435 (32%)
		ABC_membrane	94..360	CDD:294371	73/286 (26%)
		ABCC_MRP_domain1	448..650	CDD:213217	97/203 (48%)
		ABC_membrane	821..1046	CDD:294371	72/234 (31%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	125/219 (57%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	464/1435 (32%)
		ABC_membrane	322..589	CDD:279056	69/274 (25%)
		ABCC_MRP_domain1	633..834	CDD:213217	97/203 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		6/21 (29%)
		ABC_membrane	979..1245	CDD:279056	82/309 (27%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	125/219 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660