DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcb4

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_036822.1	Gene:	Abcb4 / 24891	RGDID:	620248	Length:	1278	Species:	Rattus norvegicus

Alignment Length:	1430	Identity:	307/1430 - (21%)
Similarity:	565/1430 - (39%)	Gaps:	313/1430 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPSVVRMILRAYGKIFVPMGLAFSI 98
            |..|.||||   |:::..              |:|                  |:|:.:|.|.:|
  Rat    33 KVNLIGPLT---LFRYSD--------------WQD------------------KLFMLLGTAMAI 62

  Fly    99 SETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHP----FIFYIFQVG 159
            :......||.:..|.:...|..|..:.|      ..:...:.||.|......    :.:|...:|
  Rat    63 AHGSGLPLMMIVFGEMTDKFVDNAGNFS------LPVNFSLSMLNPGRILEEEMTRYAYYYSGLG 121

  Fly   160 TKLRLALSGLIYRKVLQVSKSSSNDGLRGRAIN------ILSNDLGRFDVALCFLHDTWKGPME- 217
                   .|::....:|||..:...|.:.|.|.      ||..::|.||:         ||..|
  Rat   122 -------GGVLLAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMGWFDI---------KGTTEL 170

  Fly   218 -------------------------------SILIGFLMYREI-----GISAVIGVSFMLSFIPL 246
                                           ..::||:...::     .|:|::|:|..:....|
  Rat   171 NTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKIL 235

  Fly   247 QAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAY 311
            ..::.|:.|.|.:..|...:....:...|..|.|..::..::|..... .::.:|  |||..
  Rat   236 STFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENA-KKIGIK--KAISA--- 294

  Fly   312 IHAALGCTSMISPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALV 376
             :.::|...::...|..||.    :.|..|...|.||:       .::|..|:  ||...|.::.
  Rat   295 -NISMGIAFLLIYASYALAF----WYGSTLVISKEYTI-------GNAMTVFF--SILIGAFSVG 345

  Fly   377 SAKRCKDFLLDGDKAEVPI--NLEANQQTGKNKRKISKKDKQK-NVELNGSLLSNGQVHHNRLRD 438
            .|..|.|...:...|...|  .::.|.:......:..|.|..| |:|.:       .||.:
  Rat   346 QAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFS-------DVHFS---- 399

  Fly   439 YDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVG 503
            |...|..|  :||.::..                  :|.....|:||..|.|||:.:.:|.....
  Rat   400 YPSRANIK--ILKGLNLK------------------VKSGQTVALVGNSGCGKSTTVQLLQRLYD 444

  Fly   504 IDKGEAMVHGK-------------ISYASQESWVFEGTIRDNIVFVEDYNERRY----------K 545
            ..:|...:.|:             |...|||..:|..||.:||         ||          |
  Rat   445 PTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENI---------RYGRGNVTMDEIK 500

  Fly   546 KVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVG 610
            |.||.......:..||:...|:||:||..||||||.|:::|||:.|...|.|||:..||:||...
  Rat   501 KAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 565

  Fly   611 KHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR------------- 662
            ..: ...:......:..|::.|::..:.:.:.:.....|.|:.|||:.||.:
  Rat   566 AEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQT 629

  Fly   663 ------SRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVNQEQQTV 721
                  |.:|:.....:....|:..:...:.:.|:.::||::.......|.|....:::.....|
  Rat   630 SGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETNELDANVPPV 694

  Fly   722 GSIKMHVYASYIKALDST----FLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLL 782
            ..:|       :..|:.|    |::|.     :|| |....:....|  :|..|.||:      .
  Rat   695 SFLK-------VLRLNKTEWPYFVVGT-----LCA-IANGALQPAFS--IILSEMIAI------F 738

  Fly   783 NETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGA---TLIVYLIRTFGFFKM 844
            ...|.|:.                         :|:..:|....||.   :...:.::.|.|.|.
  Rat   739 GPGDDTVK-------------------------QQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKA 778

  Fly   845 CLRISLHLHDRLFRGITRASMYFF--NTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSG 907
            ...::..|....|:.:.|..|.:|  :.||:|.:..|.:.|...|. ....|.|..:|......|
  Rat   779 GEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQ-GATGTRLALIAQNTANLG 842

  Fly   908 VVIIVAIANYWLL-------IP-AAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQ 964
            ..||::....|.|       :| .|:.|::  .::.|..|..|..|.:|:..:     :..:..:
  Rat   843 TGIIISFIYGWQLTLLLLSVVPFIAVAGIV--EMKMLAGNAKRDKKEMEAAGK-----IATEAIE 900

  Fly   965 GLTTIRALQAQSALEQEFHE-----YQNTNTSA--WFLFLSCTRAFALWSDVLCIVYMTAVTFSF 1022
            .:.|:.:|..:...|..:.|     |:|:...|  :.:..|.::||..:|...|..:     .|:
  Rat   901 NIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRF-----GSY 960

  Fly  1023 LLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFK 1087
            |::.......||  .::.|..:.|....|...:...:.....:.....::....:.|:::   :.
  Rat   961 LIVNGHMRFKDV--ILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDS---YS 1020

  Fly  1088 PKSEWPSK--GRIEFINFKLRYSPK-EAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-- 1147
            .:..||.|  |.:.|......|..: ..|||:.|:..::..:.:.:||.:|.|||:::|.:.|
  Rat  1021 REGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1085

  Fly  1148 --LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDER---SDEEMWKAL 1207
              :|   |.:.:|..:.:.:.:..||:|:.|:.|:|:||..::..|:...|..   |.:|:.:|.
  Rat  1086 DPMA---GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAA 1147

  Fly  1208 GDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLI 1272
            .:..:..::.||......|:.|.|:..|.||:|.:.:|||::|..::|::||||:.:|.|::|::
  Rat  1148 KEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVV 1212

  Fly  1273 QQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAAT 1337
            |:.:.......|.:.|||||.|:.::|.::|:|.|:|:|.|...:||.:.|.|...:  |..|.|
  Rat  1213 QEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMV--NIQAGT 1275

Fly 1338 1337
Rat 1276 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	307/1430 (21%)
		ABC_membrane	94..360	CDD:294371	56/312 (18%)
		ABCC_MRP_domain1	448..650	CDD:213217	56/224 (25%)
		ABC_membrane	821..1046	CDD:294371	50/244 (20%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	67/226 (30%)
Abcb4	NP_036822.1	PTZ00265	29..1271	CDD:240339	304/1424 (21%)
		ABC_membrane	58..342	CDD:279056	60/325 (18%)
		ABC_MTABC3_MDL1_MDL2	392..628	CDD:213216	69/276 (25%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	622..646		2/23 (9%)
		ABC_membrane	714..984	CDD:279056	62/323 (19%)
		ABC_MTABC3_MDL1_MDL2	1033..1272	CDD:213216	71/243 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000