Protein Alignment rdog and Tap1

DIOPT Version :9

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_114444.2
• Gene: Tap1 / 24811
• RGDID: 3817
• Length: 725
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 131/532 - (24%)
• Similarity: 236/532 - (44%)
• Gaps: 88/532 - (16%)

  Fly   851 HLHDR----LFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTL----------LDCLAF 901
            |:|.|    :||.:......||..|.:|.|.:|.::|...|...:...|          |..|||
  Rat   232 HMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAF 296

  Fly   902 IIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGL 966
            :|..|..:.:|.:.:..||.   ::...||.     |..|.:||..||:::|...:|  :....:
  Rat   297 MIWGSFYLTVVTLLSLPLLF---LLPRRLGK-----VYQSLAVKVQESLAKSTQVAL--EALSAM 351

  Fly   967 TTIRALQAQSALEQEF----HEYQNTN--------TSAWFLFLSCTRAFALWSDVLC---IVYMT 1016
            .|:|:...:....|:|    .|.:..|        |..|.:.:         |.:|.   |:|:.
  Rat   352 PTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSV---------SGMLLKVGILYLG 407

  Fly  1017 AVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLE 1081
            ..    |:::....||::...:|:....|...:..:.....::..:.:.|::.||.::
  Rat   408 GQ----LVVRGAVSSGNLVSFVLYQLQFTRAVEVLLSIYPSMQKSVGASEKIFEYLDR------- 461

  Fly  1082 TPEKFKPKSEWP--SKGRIEFINFKLRY-SPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSI-- 1141
            ||......|..|  .||.::|.:....| :.....||:.|.||:.|.:...:||..|:|||::
  Rat   462 TPCSPLSGSLAPLNMKGLVKFQDVSFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAA 526

  Fly  1142 -IQSIFRLACNEGMIRIDD---VDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNL-------DPM 1195
             :|::::  ...|.:.:|.   |..:|   |.|.:||:.:.|:|:||..:.|.|:       ..|
  Rat   527 LLQNLYQ--PTGGKVLLDGELLVQYDH---HYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTPTM 586

  Fly  1196 DERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEA 1260
            :|.:...|.....|     ::|....|.:..:.:.|:..|.||||.|.||||::|..::||:|:|
  Rat   587 EEITAVAMESGAHD-----FISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDA 646

  Fly  1261 TANVDPETDKLIQQTI--RSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323
            |:.:|......:|:.:  ..::|..|||.|..:|.....:..:|.:..|.|.|.|...:|::| |
  Rat   647 TSALDAGNQLRVQRLLYESPEWASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLMER-G 710

  Fly  1324 GYLRQLVDNTGA 1335
            |..|.:|:...|
  Rat   711 GCYRSMVEALAA 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	131/532 (25%)
		ABC_membrane	94..360	CDD:294371
		ABCC_MRP_domain1	448..650	CDD:213217
		ABC_membrane	821..1046	CDD:294371	49/223 (22%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	66/234 (28%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	129/525 (25%)
		ABC_membrane	177..435	CDD:279056	50/225 (22%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	352..397		9/53 (17%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	430..464		5/40 (13%)
		P-loop_NTPase	469..697	CDD:304359	66/237 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000