Protein Alignment rdog and Abcc1

DIOPT Version :9

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_071617.2
• Gene: Abcc1 / 24565
• RGDID: 3112
• Length: 1532
• Species: Rattus norvegicus
• Alignment Length: 1437
• Identity: 491/1437 - (34%)
• Similarity: 732/1437 - (50%)
• Gaps: 220/1437 - (15%)

  Fly     7 KVVRPKNPF--TKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDE 69
            :.||..||.  :.|:|.|:.:|||:..:..:|.:.||...:|:...|...||.|.......|:.|
  Rat   200 ETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKE 264

  Fly    70 LKRS------------------------------------------NPSVVRMILRAYGKIFVPM 92
            ..:|                                          :||:.:::.:.:|..|: |
  Rat   265 CVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFL-M 328

  Fly    93 GLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQ 157
            ...:.....:.....|..|..::.:  .|..:..:...|||...:.:...:..:..|.:....|.
  Rat   329 SFLYKALHDLMMFAGPEILELIINF--VNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFV 391

  Fly   158 VGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIG 222
            .|.:::.|:.|.:|||.|.::.|:......|..:|::|.|..||.....:::..|..|::..|..
  Rat   392 TGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLAL 456

  Fly   223 FLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAW 287
            :.::..:|.|.:.||:.|:..:|..|..|.|...|:....:..|.|:||||||:.||:|:|:|||
  Rat   457 YFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAW 521

  Fly   288 EKSFARVIAEVRLKEVKAIRGTAYIHAALG-----CTSMISPLSVFLALCSYVYLGDP--LTAQK 345
            |.:|...:..:|.:|:|.::.:||: ||:|     ||..:..||.|..   :|.:.:.  |.|:|
  Rat   522 ELAFQDKVMNIRQEELKVLKKSAYL-AAVGTFTWVCTPFLVALSTFAV---FVTVDEKNILDAKK 582

  Fly   346 VYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFL----LDGDKAEVPINLEANQQTGKN 406
            .:...:.||:|...: ...||.|:.|.:|.||.||.:.||    |:.|..|
  Rat   583 AFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-------------- 632

  Fly   407 KRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDF 471
              :.|.||       .|.:.|                    :.:||.:.:|...:..   .:...
  Rat   633 --RWSIKD-------GGGMNS--------------------ITVKNATFTWARDEPP---TLNGI 665

  Fly   472 STDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFV 536
            :..|.|..|.||||.||.||||.|:.||.|:...:|...:.|.::|..|::|:...::|:||:|.
  Rat   666 TFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFG 730

  Fly   537 EDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDP 601
            ....|..||.|::.|.|..|:|:||.||||.:||:||:||||||.|||||||||..:||||||||
  Rat   731 RPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDP 795

  Fly   602 LSAVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSR 664
            |||||.|||||||::.:  ...|.||.||||||.:.||..|:.:::|..|||...|||||| ..|
  Rat   796 LSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQEL-LDR 859

  Fly   665 QFQFLE------QTQHD---------------------ESGI-DTHSVSS----YLSRSDSEK-- 695
            ...|.|      .|:.|                     |:|| .|.:|..    :||.|.|..
  Rat   860 DGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVV 924

  Fly   696 -SMEHQHNQLLRPDEHVED----VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVIS-----LFV 750
             :.:|.....|:.....|:    :..::...|.:|:.||.:|:||      :|:.||     ||:
  Rat   925 TNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKA------IGLCISFLSIFLFL 983

  Fly   751 CARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGI 815
            |..:.....:|:||.|.  :::.|||.|
  Rat   984 CNHVSALASNYWLSLWT--DDRPAVNGT------------------------------------- 1009

  Fly   816 RQELVLFYATILGATLIVYLIRTFGFFKMCLRI-----SLHLHDRLFRGITRASMYFFNTNSSGR 875
             ||...|..::.||..|:..:..|| :.|.:.|     |..||..|.:.:.|:.|.||....||.
  Rat  1010 -QENRNFRLSVYGALGILQGVAVFG-YSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGN 1072

  Fly   876 ILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAII---GVILGMIRYLY 937
            ::|||||::.|||:.:|..:...:..:..|.|.|||:.:|.   .|.|.||   |::...::..|
  Rat  1073 LVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLAT---PIAAVIIPPLGLVYFFVQRFY 1134

  Fly   938 VNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRA 1002
            |.:||.:|||||:|||||:|..|:|..|::.|||.:.|....::.....:.|..|::..:...|.
  Rat  1135 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRW 1199

  Fly  1003 FALWSDVL--CIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSV 1065
            .|:..:.:  |||...|: |: ::.:....:|.|||::.:|..:|....|.:|.::|:|..:.:|
  Rat  1200 LAVRLECVGNCIVLFAAL-FA-VISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAV 1262

  Fly  1066 ERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGI 1130
            ||:.||:|...||..:..|. .|.|.||..||:||.::.|||......|||.:|.|||..||:||
  Rat  1263 ERLKEYSETEKEASWQIQET-APPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGI 1326

  Fly  1131 VGRTGAGKSSIIQSIFRL-ACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDP 1194
            ||||||||||:...:||: ...||.|.||.::|..||||:||.:::|||||||||||:||.||||
  Rat  1327 VGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDP 1391

  Fly  1195 MDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDE 1259
            ..:.||||:|.||....|:.:||.|...||....:||.|.|||||||||||||:||..|||::||
  Rat  1392 FSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1456

  Fly  1260 ATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGG 1324
            |||.||.|||.|||.|||::|...|||||||||:|:||..||:|:|.||:||.|.|.||||:.|.
  Rat  1457 ATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGV 1521

  Fly  1325 YLRQLVD 1331
            :.....|
  Rat  1522 FYSMAKD 1528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	489/1432 (34%)
		ABC_membrane	94..360	CDD:294371	72/272 (26%)
		ABCC_MRP_domain1	448..650	CDD:213217	95/203 (47%)
		ABC_membrane	821..1046	CDD:294371	74/234 (32%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	131/219 (60%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	491/1437 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660