DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and Cftr

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_006236159.1 Gene:Cftr / 24255 RGDID:2332 Length:1530 Species:Rattus norvegicus


Alignment Length:1513 Identity:416/1513 - (27%)
Similarity:702/1513 - (46%) Gaps:273/1513 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RTRRKV----VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFA 63
            ||:..|    :..|:|..||:|.|:..|.|...:.::|.:..|...::||...:..::.::.|..
  Rat    44 RTQTLVHHGDIMQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLE 108

  Fly    64 ELWE-DELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISE 127
            ..|: ::..:..|.::..:.|.:...||..|:...:.| :.|::.|:.||.::..:..:.|:  |
  Rat   109 REWDREQASKKKPQLIHALRRCFVWRFVFYGVLLYLGE-VTKAVQPVLLGRIIASYDPDNTE--E 170

  Fly   128 NTAYLYAMGIVICML--VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRA 190
            .:..:| :||.:|:|  |..:..||.||.:..:|.::|:|:..|||:|.|::|....:....|:.
  Rat   171 RSIAIY-LGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 234

  Fly   191 INILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAA 255
            |::|||:|.:||..|...|..|..|::.:|:..|::..:..||..|:..::..:..||...|...
  Rat   235 ISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMV 299

  Fly   256 YYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTS 320
            .||...|.:.:.|:.:.:|:|..|..:|.|.||.:..::|..:|.:|:|..|.:||:........
  Rat   300 KYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAF 364

  Fly   321 MISP-LSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDF 384
            ..|. ..|||::..|..: :.:..:|::|..|:..:|..|:...:|.::....::|...::.:||
  Rat   365 FFSGFFVVFLSVLPYTVI-NGIVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDF 428

  Fly   385 LLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVV 449
            |                ||          .:.|.:|.|  |:..|                  :|
  Rat   429 L----------------QT----------QEYKVLEYN--LMFTG------------------LV 447

  Fly   450 LKNVSASWD------------------TSDGH-----------ANCAIEDFSTDIKDQTLAAVVG 485
            ::||:|.|:                  ||:|.           .|..:::.:.:||...:.|:.|
  Rat   448 MENVTAFWEEGFQELLEKVQLNNDDRKTSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITG 512

  Fly   486 PVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKV 550
            ..||||:|.|.::|||:...:|.....|::|::||.||:..|||::||:|...|:|.|||.|||.
  Rat   513 STGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKA 577

  Fly   551 CGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFD 615
            |.|:.|:......|.||:||.||:|||||:||:|||||||:.||:||||.|...:|....:.||:
  Rat   578 CQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFE 642

  Fly   616 RCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSR-QFQ--------FLEQ 671
            .|:...:::|.|||||.:::.|...:.:|::..|.....|::.|||..| .|.        |.:.
  Rat   643 SCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQF 707

  Fly   672 TQHDESGIDTHSV------------------------------SSYLSRSDSEK----------S 696
            |:...|.|.|.::                              :|.||...|.|          |
  Rat   708 TEERRSSILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLS 772

  Fly   697 MEHQHNQL------LRPD-EHVEDV---------------------------------NQEQQTV 721
            :|.:.:.|      |.|| ||.|..                                 :..|:|.
  Rat   773 IEGESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQRTR 837

  Fly   722 GSIKMHVYASYIK-----------ALDST-----------------------------------F 740
            .||:....|..|.           :.|||                                   |
  Rat   838 ASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYF 902

  Fly   741 LL--GIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYI 803
            .|  |:...|..|..:.|  |:...|.:|:|           ||........|:...| |...|:
  Rat   903 TLHRGLFAVLIWCVLVFL--VEVAASLFVLW-----------LLKNNPVNGGNNGTKI-ANTSYV 953

  Fly   804 APLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFF 868
            ..:.:|..     ..:...|..:....|.:.|.|........:..|..||.::...|..|.|..|
  Rat   954 VVITSSSF-----YYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTF 1013

  Fly   869 NTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIV-AIANYWLL--IPAAIIGVIL 930
            |...:|.|||||||||..:|..||.|:.|.:..:..|.|.:|:| |:..|..|  :|...:.::|
  Rat  1014 NKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAVFILL 1078

  Fly   931 GMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFL 995
               |..:::||:.:|:|||..|||:|:....:.:||.|:||.:.|:..|..||:..|.:|:.||:
  Rat  1079 ---RAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFM 1140

  Fly   996 FLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELEN 1060
            :|:..|.|.:..|::.:::...|||..:|...| ..|..|:.:..:..:....||.:..:.:.::
  Rat  1141 YLATLRWFQMRIDMIFVLFFIVVTFISILTTGE-GEGTTGIILTLAMNIMSTLQWAVNSSIDTDS 1204

  Fly  1061 QMTSVERVLEY------------------TEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRY 1107
            .|.||.||.::                  :|....||:...|..|....|||.|.:...:..::|
  Rat  1205 LMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGEMVVKDLTVKY 1269

  Fly  1108 SPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRS 1172
            ......:|::::|:|.|.:::|::||||:|||:::.:..|:...:|.|:||.|....:.|.:.|.
  Rat  1270 VDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGVSWNSMTLQEWRK 1334

  Fly  1173 QVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVG 1237
            ...:|.|...:||||.|.||||..:..|||:||....|.|:|.:....|.||..:.|||...|.|
  Rat  1335 AFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGGYVLSHG 1399

  Fly  1238 QRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVL 1302
            .:||:||||::|...||:::||.:||:||.|.::|::.:|..||.|||:...||:..::|..|.|
  Rat  1400 HKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFL 1464

  Fly  1303 VMDAGEVRELGHPYELLQ 1320
            |::.|.|.:    ||.||
  Rat  1465 VIEQGNVWQ----YESLQ 1478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 413/1500 (28%)
ABC_membrane 94..360 CDD:294371 73/268 (27%)
ABCC_MRP_domain1 448..650 CDD:213217 86/230 (37%)
ABC_membrane 821..1046 CDD:294371 71/227 (31%)
ABCC_MRP_domain2 1096..1315 CDD:213211 80/218 (37%)
CftrXP_006236159.1 CFTR_protein 55..1518 CDD:273530 413/1502 (27%)
ABC_membrane 139..357 CDD:294371 65/221 (29%)
ABCC_CFTR1 444..724 CDD:213258 99/297 (33%)
CFTR_R 693..898 CDD:291094 29/204 (14%)
ABC_membrane 915..1196 CDD:279056 86/303 (28%)
P-loop_NTPase 1258..1518 CDD:304359 84/225 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345090
Domainoid 1 1.000 58 1.000 Domainoid score I10508
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.950

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