DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and Abcc4

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001028508.2 Gene:Abcc4 / 239273 MGIID:2443111 Length:1325 Species:Mus musculus


Alignment Length:1387 Identity:546/1387 - (39%)
Similarity:817/1387 - (58%) Gaps:130/1387 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRS 73
            |:| ||...||..|:..|||:..|||.|.:..|.:::::.......|:.:..:....|:.||.|:
Mouse     8 VKP-NPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRA 71

  Fly    74 -----NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTD--ISENTAY 131
                 .||:.:.|::.|.|.::.:|: |::.|...:.:.|||||.::.||.....|  ::.:|||
Mouse    72 KKDSRKPSLTKAIIKCYWKSYLILGI-FTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAY 135

  Fly   132 LYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSN 196
            .||..:.:|.|:..|..|.:.:::...|.:||:|:..:||||.|::|.|:......|:.:|:|||
Mouse   136 GYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSN 200

  Fly   197 DLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMT 261
            |:.:||....|||..|.||:::|.:..|::.|||||.:.|::.::..:|||:...|..:..|..|
Mouse   201 DVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRSKT 265

  Fly   262 AERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAA-LGCTSMISPL 325
            |..||.|::.|||:|.|:::|||||||||||.:||.:|.||:..|.|::|:... :....:.:.:
Mouse   266 AAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIANKV 330

  Fly   326 SVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGD- 389
            .:|:...|||.||:.:||..|:...:.:..:..::..|:|.:|...:||:||.:|.|:|||..: 
Mouse   331 ILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLDEL 395

  Fly   390 ---KAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLK 451
               ||.||                                |:|               |..|.::
Mouse   396 PQRKAHVP--------------------------------SDG---------------KAIVHVQ 413

  Fly   452 NVSASWDTS-DGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKI 515
            :.:|.||.: |   :..::..|...:...|.||||||||||||.|:.:|||:....|...|||:|
Mouse   414 DFTAFWDKALD---SPTLQGLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRI 475

  Fly   516 SYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQK 580
            :|.||:.|||.||:|.||:|.:.|.:.||:||:|.|.|::|::||..|||||:|:||.:||||||
Mouse   476 AYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQK 540

  Fly   581 ARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLL 645
            |||:||||||:.||||||||||||||..||||:|..||...|..||.||||||:|||....|:|:
Mouse   541 ARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILI 605

  Fly   646 MGSGKIMAQGSYQELQRSR-QFQFLEQTQHDESGID-----------THSVSSYLSRSDSEKSM- 697
            :..|:::.:|:|.|..:|. .|..|.:.:::|:...           |.|.:|..|:..|..|: 
Mouse   606 LKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLK 670

  Fly   698 -------EHQHNQLLRPDEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIM 755
                   :.::.|.::|        :|.::.|.|....|.:|..|..|.|.:..::.|.:..::.
Mouse   671 DGAPEGQDAENTQAVQP--------EESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVF 727

  Fly   756 LTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIAN----DTLPINATDPYIAPLLASDIQAGIR 816
            ....|::||.|.  .:|.|:|.|..         ||    :||.::......|.|.|..:..||.
Mouse   728 YVLQDWWLSHWA--NKQGALNNTRN---------ANGNITETLDLSWYLGIYAGLTAVTVLFGIA 781

  Fly   817 QELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFS 881
            :.|::||                    :.:..|..||:|:|..|.:|.:.||:.|..||||||||
Mouse   782 RSLLVFY--------------------ILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFS 826

  Fly   882 KDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKR 946
            |||..:|..||.|.||.:..::.|..|:.:.|....|:|||...:.|:..::|..::.|||.|||
Mouse   827 KDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKR 891

  Fly   947 LESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLC 1011
            |||.:||||||..:.:.|||.||||.:|:...::.|..:|:.::.||||||:.:|.||:..|.:|
Mouse   892 LESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAIC 956

  Fly  1012 IVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPS 1076
            .:::..|.|..|:|....::|.||||:.::.|:.||.||.:||:||:||.|.|||||:|||:...
Mouse   957 AIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEK 1021

  Fly  1077 EALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSI 1141
            ||..|.  |.:|...||.:|.|.|.|....||.....|||.|...|:.|||:||||||||||||:
Mouse  1022 EAPWEC--KKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSL 1084

  Fly  1142 IQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKA 1206
            |.::|||:..||.|.||.:....|||||||.::|||||:||||:||:|.||||.:|.:|||:|:|
Mouse  1085 ISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWRA 1149

  Fly  1207 LGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKL 1271
            |.:|:|:..:..|.|.::..:.:.|||||||||||||||||||::|:|||:|||||||||.||:|
Mouse  1150 LEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTDEL 1214

  Fly  1272 IQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAA 1336
            |||.||.|||.||||||||||:|::|||:::|:|:|.::|...||.|||.......::|...|..
Mouse  1215 IQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNPESLFYKMVQQLGKG 1279

  Fly  1337 TSFALQQAAEQSYSKQILGDDT 1358
            .:.||.:.|:|.|.::...|.|
Mouse  1280 EAAALTETAKQVYFRRNYPDIT 1301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 539/1367 (39%)
ABC_membrane 94..360 CDD:294371 95/268 (35%)
ABCC_MRP_domain1 448..650 CDD:213217 109/202 (54%)
ABC_membrane 821..1046 CDD:294371 84/224 (38%)
ABCC_MRP_domain2 1096..1315 CDD:213211 130/218 (60%)
Abcc4NP_001028508.2 PLN03130 12..1284 CDD:215595 536/1363 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 657..690 6/40 (15%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:O15439 1322..1325
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841684
Domainoid 1 1.000 97 1.000 Domainoid score I7210
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.760

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