DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcc10

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001334325.1	Gene:	Abcc10 / 224814	MGIID:	2386976	Length:	1526	Species:	Mus musculus

Alignment Length:	1435	Identity:	434/1435 - (30%)
Similarity:	689/1435 - (48%)	Gaps:	200/1435 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PKNPFTKANF-----------------FSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSER- 57
            |:.|:|...|                 .|::|:.|:..|..||::|     ||.|.|.|....|
Mouse   195 PQEPWTHDPFLSSESQETEVAEDGESWLSRFSYAWLAPLLARGVRG-----ELQQPRDTCRLPRR 254

  Fly    58 -----VTNKFAELWEDELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGY 117
                 :...|...|::     ...:.|.:.||:|..::.:||...:. |:.....||.|..|||:
Mouse   255 LHPAFLARVFQAHWKE-----GAQLWRALYRAFGCCYLALGLLKMVG-TMLGFSGPLLLSLLVGF 313

  Fly   118 FATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSS 182
            ....|..:|.  ..||.:|:....::..:..:.:.:.:.:|..:.|:|:...:|||.|::..|..
Mouse   314 LEEGQEPLSH--GLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSRP 376

  Fly   183 NDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQ 247
            .   .|..:|:|..|..|........|:.|..|::..:..:|:|:::|::.:.|:...|..:|:.
Mouse   377 P---TGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVN 438

  Fly   248 AWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYI 312
            ...|.:.....|......|.|||||.|::.||:|||.:.||::....:...|.||:..:|...|:
Mouse   439 KVIATRIMASNQEMLRHKDARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYL 503

  Fly   313 HAALGCTSMISPLSVFLAL---CSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEA 374
            .||  |..:.:.|.|.:.:   .:||.:|..|||.||:|..:...||...:..| |..|..:.|:
Mouse   504 DAA--CVYLWAALPVVICITIFITYVLMGHQLTATKVFTALALVRMLILPLNNF-PWVINGLLES 565

  Fly   375 LVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDY 439
            .||..|.:.||      ::|                                           .|
Mouse   566 KVSLDRIQRFL------DLP-------------------------------------------SY 581

  Fly   440 DPEA---------TKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFL 495
            .|||         ....:.|.....|||.........|...  .:|...|..:||.||.||||.|
Mouse   582 SPEAYYSPDPPAEPSTALELHEALFSWDPIGASQKTFISHL--QVKKGMLVGIVGKVGCGKSSLL 644

  Fly   496 NVLLGEV----------GIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKV 550
            ..:.||:          .:.||       ...|:||.|:...||||||:|.:.::.:.|::|::.
Mouse   645 AAITGELHRLCGWVAVSELSKG-------FGLATQEPWIQCATIRDNILFGKTFDAQLYREVLEA 702

  Fly   551 CGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFD 615
            |.|..|:.:||.||.|.|||:||:|||||:||::||||||::..:|||||||:|||..|..|:..
Mouse   703 CALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLLH 767

  Fly   616 RCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQE---LQRSRQFQFLEQTQHDES 677
            |||...||:..|:|.||:.:||...:.:|||.:|:::..|...|   |.::....:.|:.|...|
Mouse   768 RCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILPLVQAVPTAWAEKEQVATS 832

  Fly   678 GIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLL 742
            | .:.||......::.|..:|......|        |.:|.::.|::.:|||.:|.:|:.|....
Mouse   833 G-QSPSVCDLERTTEEELEVEQSTCGCL--------VQEESKSEGAVALHVYRAYWRAMGSGLAA 888

  Fly   743 GIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTL---------PINA 798
            .|::||.: .:....|.|::|:.|:   .|:...|..:..:....:..:..|         |.|.
Mouse   889 AILVSLLL-MQATRNGADWWLAHWL---SQLKAGRNGSREDPASCSPGSTALFSPRLLLFSPGNL 949

  Fly   799 TDPYIA-PL--LASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGI 860
            ..|.:: ||  .||:..|.:...|:: ||||.|...:..|:|...|....|:.:..||.||...:
Mouse   950 YTPLLSTPLHKAASNGTADVHFYLIV-YATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRL 1013

  Fly   861 TRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAI 925
            ..|.:.|:::..|||:|||||.|:..||..||..|...||..:.:.|::.::.....|||:....
Mouse  1014 LMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPP 1078

  Fly   926 IGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNT 990
            :..:...::..|..:.|.::||.|::.||::|....|..||..:||..|....|:|.......|.
Mouse  1079 LSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLLELNQ 1143

  Fly   991 SAWFLFLSCTRAFALWSDVLCIVYMTAVTFS---FLLLKDE---FDSGDVGLAILHSTTMTGMCQ 1049
            ...|    .:.|...|.|:...:...||..:   ..|::.:   .:.|.|||.:.::.::||:..
Mouse  1144 RCQF----ASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLSYALSLTGLLS 1204

  Fly  1050 WGMRQTAELENQMTSVERVLEYT----EQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPK 1110
            ..:....:.|..|.||||:.||:    ::|....|::|.  :.:..|.::|.:||.:..|.|.|.
Mouse  1205 GLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPH--QQRISWLTQGSVEFQDVVLVYRPG 1267

  Fly  1111 EAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQV 1174
            ....|..:.|.:||.||:|||||||:||||:...:|| |..|.|.:.:|:||...:.|.:||||:
Mouse  1268 LPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVDTSQLELAELRSQL 1332

  Fly  1175 SIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYV----------------------- 1216
            ::|||:|.|||||:|.||||.....|..:|:||....|....
Mouse  1333 AVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQACQRSQREAKNGHWQC 1397

  Fly  1217 -STLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKF 1280
             :.|.|||:..:.:.|.|.|:|||||:|||||:|...|||.:|||||:||.:||:|:||||..:|
Mouse  1398 SALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRF 1462

  Fly  1281 AHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAA 1345
            |:.|||||||||:|:::||||||:.||.|.||..|..|..:.....:||:.::        ||.|
Mouse  1463 ANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFQQLLQSS--------QQGA 1519

  Fly  1346 EQSYS 1350
            ....|
Mouse  1520 HSGPS 1524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	429/1425 (30%)
		ABC_membrane	94..360	CDD:294371	72/268 (27%)
		ABCC_MRP_domain1	448..650	CDD:213217	85/211 (40%)
		ABC_membrane	821..1046	CDD:294371	63/230 (27%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	113/243 (47%)
Abcc10	NP_001334325.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650