DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Tap2

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_035660.3	Gene:	Tap2 / 21355	MGIID:	98484	Length:	702	Species:	Mus musculus

Alignment Length:	682	Identity:	159/682 - (23%)
Similarity:	289/682 - (42%)	Gaps:	134/682 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 GSIKMHVYASYIKALDSTFLLGIVISLFVCA--------------------RI-------MLTGV 759
            |::::.|....:|..:...|:|.::.|...|                    |:       :|.|.
Mouse    42 GTLRLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWLLAGY 106

  Fly   760 DYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATD-PYIAPLLASDIQAGIRQELVLFY 823
            ......|.:|..............:.:.|:....|.::..| |::.......:.|...:.|:..|
Mouse   107 GAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRY 171

  Fly   824 A----TILGATLIVYLIRTFGFFKMCL---------------------RISLHLHDRLFRGITRA 863
            :    .|||.........:..|| |||                     ||:|.:.::||..:.|.
Mouse   172 SGRVIDILGGDFDPDAFASAIFF-MCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQ 235

  Fly   864 SMYFFNTNSSGRILNRFSKDIRTVDTDLP---HTLLDCLA-------FIIDVSGVVIIVAIANYW 918
            .:.||....:|.:.:|.|.|...:...||   :.||..|.       |::.||..:..:::.:..
Mouse   236 DLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLP 300

  Fly   919 LLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFH 983
            |.|.|          ..:|....::|.:....:.:....:..:...||.|:|:..|:   |||..
Mouse   301 LTIAA----------EKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAE---EQEVS 352

  Fly   984 EYQNT---NTSAWF-------LFLSCTRAFALWSDVLCI------VYMTAVT----FSFLLLKDE 1028
            .|:..   ....|:       ::|...|..||...||.:      :....||    .||||.::|
Mouse   353 HYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEE 417

  Fly  1029 FDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQ----PSEALLETPEKFKPK 1089
                 ||..:.:...|.|          ::.:.:.:.|:|..|.::    |...:|..|
Mouse   418 -----VGQYVRNLVYMYG----------DMLSNVGAAEKVFSYLDRKPNLPQPGILAPP------ 461

  Fly  1090 SEWPSKGRIEFINFKLRYSPK-EAPVLKDLNFTIEPREKIGIVGRTGAGKSSI---IQSIFRLAC 1150
              | .:||:||.:....|..: |.|||:.|.||:.|.....:||..|:|||::   :|::::  .
Mouse   462 --W-LEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQ--P 521

  Fly  1151 NEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLD-PMDERSDEEMWKALGDVELRS 1214
            ..|.:.:|...:.....|.|..||.::.|:||||||:::.|:. .:.:..|.::..|........
Mouse   522 TGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADD 586

  Fly  1215 YVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSK 1279
            ::..:..|:|..:.:.|...:|||:|.:.:|||::|:.::||:||||:.:|.:.::.:|.. ||:
Mouse   587 FIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNW-RSQ 650

  Fly  1280 FAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRE 1311
             ...|:|.||||||||.::|:|||:..|.:.|
Mouse   651 -GDRTMLVIAHRLHTVQNADQVLVLKQGRLVE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	159/682 (23%)
		ABC_membrane	94..360	CDD:294371
		ABCC_MRP_domain1	448..650	CDD:213217
		ABC_membrane	821..1046	CDD:294371	60/279 (22%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	73/221 (33%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	159/682 (23%)
		ABC_membrane	155..415	CDD:279056	58/273 (21%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03519	300..388		19/100 (19%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03519	413..432		6/33 (18%)
		P-loop_NTPase	456..679	CDD:304359	75/235 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000