Protein Alignment rdog and Abcc9

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_035641.1
• Gene: Abcc9 / 20928
• MGIID: 1352630
• Length: 1546
• Species: Mus musculus
• Alignment Length: 1426
• Identity: 418/1426 - (29%)
• Similarity: 706/1426 - (49%)
• Gaps: 200/1426 - (14%)

  Fly     9 VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLD----------SERVTNK-- 61
            ||...||  .|..|:.::|||..|.            :..|||.:|          ...|||.
Mouse   213 VRFLQPF--VNLLSKATYWWMNTLI------------ISAHRKPIDLKAIGKLPIAMRAVTNYVC 263

  Fly    62 FAELWEDELKRS------NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYF-- 118
            ..|.:|::.|::      .||:...:.||:|:..: :...|.....:.....||.:.|:|...
Mouse   264 LKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPIL-LSSTFRYLADLLGFAGPLCISGIVQRVNE 327

  Fly   119 ATNQT-----------DISENTAYLYAMGIVICMLVPVITFHPFIFYI-FQVGTKLRLALSGLIY 171
            .||.|           :..|| |::.|: ::...|:...||....:|: .:.|..||.||..:||
Mouse   328 KTNTTREMFPETLSSKEFLEN-AHVLAV-LLFLALILQRTFLQASYYVTIETGINLRGALLAMIY 390

  Fly   172 RKVLQVSKSSSNDG--LRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAV 234
            .|:|::|.|:.:.|  ..|:..|:::.:..:....|....:.|..|::.|:...|:|..:|.||:
Mouse   391 NKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSAL 455

  Fly   235 IGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVR 299
            :|.:.::...|:|.:.|.|.|..::.|.:.:..|:|..|||::||:::|:||||..|.:.:.|.|
Mouse   456 VGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETR 520

  Fly   300 LKEVKAIRGTA-YIHAALGCTSMISPLSVFLALCSYVYL-GDPLTAQKVYTVSSYFNMLNDSMVT 362
            :||:.:::..| |...::...:.|...:|.....::.|. |:.|...:.:...|.|::|   :..
Mouse   521 MKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL---VTP 582

  Fly   363 FWPMS--ITFIAEALVSAKRCKDFLLDGDKAE---------VPINLEANQQTGKNKRKISKKDKQ 416
            .:.:|  :.|..:|::|.::..:|||..:..|         :|.. ...:.||...:.|::|..
Mouse   583 LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTLPFE-SCKKHTGVQSKPINRKQP- 645

  Fly   417 KNVELNGSLLSNGQVH---HNRLRDYDPEATKKCVV-LKNVSASWDTSDGHANCAIEDFSTDIKD 477
                        |:.|   :.:.|...|..|:...: :.|...||    |.....:.:....|..
Mouse   646 ------------GRYHLDSYEQARRLRPAETEDIAIKVTNGYFSW----GSGLATLSNIDIRIPT 694

  Fly   478 QTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHG-----------------KISYASQESWVF 525
            ..|..:||.||.||||.|..:|||:...:|:...:.                 .::||:|:.|:.
Mouse   695 GQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLL 759

  Fly   526 EGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVY 590
            ..|:.:||.|...:|.:|||.|...|.|:.|::|||.||.|.:||||::|||||:.|:.:|||:|
Mouse   760 NATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 824

  Fly   591 RKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIR--ILVTHQVQYLFDVEHLLLMGSGKIMA 653
            :..:|..||||.||:|.|:..|:....|..||.:..|  :||||::|||...:.::.|..|.::.
Mouse   825 QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLR 889

  Fly   654 QGSYQELQ-------------RSRQFQFLEQ-TQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQL 704
            :|:.:::|             .:||.|.||: .:.|::.::..::...:...:::..||.:..:
Mouse   890 EGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEE- 953

  Fly   705 LRPDEHVEDVNQEQQTVGSIKMHVYAS----YIKALDSTFLLGIVISLFVCARIMLTGVDYFLSR 765
               :|..||......||..::..:...    |:.: ...|||.::|...:....::..:||:|:.
Mouse   954 ---EEEEEDEEDNMSTVMRLRTKMPWKTCWWYLTS-GGFFLLFLMIFSKLLKHSVIVAIDYWLAT 1014

  Fly   766 WVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGAT 830
            |.   .:.::|..    .:.|.|.            |:|.                 ::.:.||.
Mouse  1015 WT---SEYSINHP----GKADQTF------------YVAG-----------------FSILCGAG 1043

  Fly   831 LIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTL 895
            :.:.|:.:.....|.|..:.:||..|...|....:.||:|...|.||||||.|...:|..:|.||
Mouse  1044 IFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1108

  Fly   896 -------LDCLAFI--IDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESIS 951
                   |.||:.|  |..:..|.:||:|.         :||....|:..:...|:.::.|:..:
Mouse  1109 ESLTRSTLLCLSAIGMISYATPVFLVALAP---------LGVAFYFIQKYFRVASKDLQELDDST 1164

  Fly   952 RSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV------L 1010
            :.|:....::|.:|||||||.:.::..:|...|..:||..| :||||....   |.:|      .
Mouse  1165 QLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA-YLFLSAANR---WLEVRTDYLGA 1225

  Fly  1011 CIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQP 1075
            |||    :|.|...:....:||.|||.:|::.|:|....|.:|..|:||.||.:|::|..:....
Mouse  1226 CIV----LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1286

  Fly  1076 SEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSS 1140
            ||....|.:..:....||.:|.|:..:..:||.....||||.:...|:|.:|:||.||||:||||
Mouse  1287 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSS 1351

  Fly  1141 IIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMW 1204
            :..:.||:. ..:|.|.||.:||..:.||.|||::|||.|||:||||::|:||||..:.:|:.:|
Mouse  1352 LSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLW 1416

  Fly  1205 KALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETD 1269
            :||...:|::.|.:|.|||:..:.:||.|||||||||.|||||.:|.:.|||||||||::|..|:
Mouse  1417 EALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1481

  Fly  1270 KLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLV 1330
            .::|:.:.:.||..||:|||||:||::.:|.|:||..|.:.|...|..||.:..|.....|
Mouse  1482 NILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFV 1542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	414/1412 (29%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	418/1426 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	941..964		5/26 (19%)