Protein Alignment rdog and Abcc8

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_036008753.1
• Gene: Abcc8 / 20927
• MGIID: 1352629
• Length: 1597
• Species: Mus musculus
• Alignment Length: 1487
• Identity: 435/1487 - (29%)
• Similarity: 717/1487 - (48%)
• Gaps: 269/1487 - (18%)

  Fly     3 RTRRKVVRPKN----------PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSER 57
            :|.|:|..|::          ||  .|..|:.::|||....|..            |||.:|...
Mouse   199 KTPREVKPPEDLQDLGVRFLQPF--VNLLSKGTYWWMNAFIKTA------------HRKPIDLRA 249

  Fly    58 V----------TN--KFAELWEDELKRSNPS------VVRMILRAYGKIFVPMGLAFSISETICK 104
            :          ||  :....::.:.::...|      :.|.:..|:|:..| :...|.|...:..
Mouse   250 IGKLPIAMRALTNYQRLCAAFDAQARKDTQSQQGARAIWRALCHAFGRRLV-LSSTFRILADLLG 313

  Fly   105 SLMPLFLGGLVG------------------YFATNQTDISENTAYLYAMGIVICMLVPVITFHPF 151
            ...||.:.|:|.                  ||.::|..:  ..||:.|:.:.:.:|:. .||...
Mouse   314 FAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFL--GNAYVLAVLLFLALLLQ-RTFLQA 375

  Fly   152 IFYI-FQVGTKLRLALSGLIYRKVLQVSKSSSNDG--LRGRAINILSNDLGRFDVALCFLHDTWK 213
            .:|: .:.|..||.|:...||.|::.:|.|:.:.|  ..|:..|:::.|..:.........:.|.
Mouse   376 SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWA 440

  Fly   214 GPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQG 278
            .|::.|:...|:|..:|:||:||.:.::...|:|.:.|.|.:..::.|.|.::.|:|..||:::|
Mouse   441 MPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRG 505

  Fly   279 IQVIKMYAWEKSFARVIAEVRLKEVKAIRGTA-------YIHAALGCTSMI-------------- 322
            |:::|:||||..|...:...|.||:.::|..|       :::.|:...:::
Mouse   506 IKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESD 570

  Fly   323 -SPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLL 386
             ||...|.:|..:..|..||     :.:||.               :....:||||.::..:||.
Mouse   571 FSPSVAFASLSLFHILVTPL-----FLLSSV---------------VRSTVKALVSVQKLSEFLS 615

  Fly   387 DGDKAE---VPINLEANQQTGK---------NKRKISKKDKQKNVELNGSLLSNGQVHHNRLR-D 438
            ..:..|   .|.......|.||         |:::.::::.:   :|.|.|        .||. .
Mouse   616 SAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVR---DLLGPL--------QRLTPS 669

  Fly   439 YDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEV- 502
            .|.:|...||.:.....:| |.||..  .:.:.:..|....|..:||.||.||||.|...|||:
Mouse   670 MDGDADNFCVQIIGGFFTW-TPDGIP--TLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQ 731

  Fly   503 ----------------GID----------------KGEAMVHGKISYASQESWVFEGTIRDNIVF 535
                            |.|                ..:|...|.::||||:.|:...|:.:||.|
Mouse   732 RVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITF 796

  Fly   536 VEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDD 600
            ...:|::|||.|::.|.|:.|:::||.||.|.:||||::|||||:.|:|:|||:|:..::..|||
Mouse   797 ESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDD 861

  Fly   601 PLSAVDTHVGKHIFDRCIRDFLSNKIR--ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS 663
            |.||:|.|:..|:....|.:.|.:..|  :||||::|||...:.::.|..|.|..:|:.::.|||
Mouse   862 PFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRS 926

  Fly   664 RQFQFLEQ----TQHDESGIDTHSVSSYLSRSDSE---KSMEHQHNQLLRPDEHVEDV--NQEQQ 719
             :.|..|.    ....:..::..:|....:...|:   ::|..:...||..||..|:.  ::|..
Mouse   927 -ECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDD 990

  Fly   720 TVGSIKMHVYA-----SYIKALDSTFLLGIVISLFVCARIM----LTGVDYFLSRWVIWEEQIAV 775
            .:.|: :|..|     :..|.|.|..:|  ::||.|.::::    |..:||:|::|
Mouse   991 NLSSV-LHQRAKIPWRACTKYLSSAGVL--LLSLLVFSQLLKHMVLVAIDYWLAKW--------- 1043

  Fly   776 NRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVL---FYATI------LGATL 831
                     ||:.:.            ::|...:   ..:.||..|   .||.:      ||..|
Mouse  1044 ---------TDSALV------------LSPAARN---CSLSQECALDQSVYAMVFTVLCSLGIAL 1084

  Fly   832 IVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLL 896
            .  |:.:.......|:::..||..|...|..|.|.||.|...|.||||||.|..|:|..:|.| |
Mouse  1085 C--LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-L 1146

  Fly   897 DCL--AFIIDVSGVVIIVAIANYWL--LIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFS 957
            :||  :.::.||.:.:|..:...:|  |:|.|::...:.  :|..| .||.:::|:..::.|:.|
Mouse  1147 ECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQ--KYFRV-ASRDLQQLDDTTQLPLLS 1208

  Fly   958 LTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV------------- 1009
            ...:|.:|||||||.:.::..:|:..||.::|..| .|||:....   |.:|
Mouse  1209 HFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIA-SLFLTAANR---WLEVRMPGPAAVLPQEY 1269

  Fly  1010 --LCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERV--LE 1070
              .|:|.:.|.|.....|..|..:|.|||.:.::..::....|.:|..|::|.|:.:|:|:  |.
Mouse  1270 IGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLL 1334

  Fly  1071 YTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTG 1135
            .||..|...|..|... ||: ||.:|:|:..|..:||.....||||.:|..|.|.:||||.||||
Mouse  1335 KTEAESYEGLLAPSLI-PKN-WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTG 1397

  Fly  1136 AGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERS 1199
            :||||...:.||:. ..||.|.||.:||..:.||.|||::|||.|||||||||:|:||||..:.|
Mouse  1398 SGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCS 1462

  Fly  1200 DEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANV 1264
            |..:|:||...:|:..|..|.|||:..:.:||.|||.|||||.|||||.:|...|.|||||||::
Mouse  1463 DSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1527

  Fly  1265 DPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQR 1321
            |..|:.::|:.:.:.||..||:|||||:||::.:|.|:|:..|.:.|...|.:||.:
Mouse  1528 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQ 1584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	431/1466 (29%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	428/1460 (29%)