DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and Abcc8

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_036008753.1 Gene:Abcc8 / 20927 MGIID:1352629 Length:1597 Species:Mus musculus


Alignment Length:1487 Identity:435/1487 - (29%)
Similarity:717/1487 - (48%) Gaps:269/1487 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RTRRKVVRPKN----------PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSER 57
            :|.|:|..|::          ||  .|..|:.::|||....|..            |||.:|...
Mouse   199 KTPREVKPPEDLQDLGVRFLQPF--VNLLSKGTYWWMNAFIKTA------------HRKPIDLRA 249

  Fly    58 V----------TN--KFAELWEDELKRSNPS------VVRMILRAYGKIFVPMGLAFSISETICK 104
            :          ||  :....::.:.::...|      :.|.:..|:|:..| :...|.|...:..
Mouse   250 IGKLPIAMRALTNYQRLCAAFDAQARKDTQSQQGARAIWRALCHAFGRRLV-LSSTFRILADLLG 313

  Fly   105 SLMPLFLGGLVG------------------YFATNQTDISENTAYLYAMGIVICMLVPVITFHPF 151
            ...||.:.|:|.                  ||.::|..:  ..||:.|:.:.:.:|:. .||...
Mouse   314 FAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFL--GNAYVLAVLLFLALLLQ-RTFLQA 375

  Fly   152 IFYI-FQVGTKLRLALSGLIYRKVLQVSKSSSNDG--LRGRAINILSNDLGRFDVALCFLHDTWK 213
            .:|: .:.|..||.|:...||.|::.:|.|:.:.|  ..|:..|:::.|..:.........:.|.
Mouse   376 SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWA 440

  Fly   214 GPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQG 278
            .|::.|:...|:|..:|:||:||.:.::...|:|.:.|.|.:..::.|.|.::.|:|..||:::|
Mouse   441 MPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRG 505

  Fly   279 IQVIKMYAWEKSFARVIAEVRLKEVKAIRGTA-------YIHAALGCTSMI-------------- 322
            |:::|:||||..|...:...|.||:.::|..|       :::.|:...:::              
Mouse   506 IKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESD 570

  Fly   323 -SPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLL 386
             ||...|.:|..:..|..||     :.:||.               :....:||||.::..:||.
Mouse   571 FSPSVAFASLSLFHILVTPL-----FLLSSV---------------VRSTVKALVSVQKLSEFLS 615

  Fly   387 DGDKAE---VPINLEANQQTGK---------NKRKISKKDKQKNVELNGSLLSNGQVHHNRLR-D 438
            ..:..|   .|.......|.||         |:::.::::.:   :|.|.|        .||. .
Mouse   616 SAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVR---DLLGPL--------QRLTPS 669

  Fly   439 YDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEV- 502
            .|.:|...||.:.....:| |.||..  .:.:.:..|....|..:||.||.||||.|...|||: 
Mouse   670 MDGDADNFCVQIIGGFFTW-TPDGIP--TLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQ 731

  Fly   503 ----------------GID----------------KGEAMVHGKISYASQESWVFEGTIRDNIVF 535
                            |.|                ..:|...|.::||||:.|:...|:.:||.|
Mouse   732 RVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITF 796

  Fly   536 VEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDD 600
            ...:|::|||.|::.|.|:.|:::||.||.|.:||||::|||||:.|:|:|||:|:..::..|||
Mouse   797 ESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDD 861

  Fly   601 PLSAVDTHVGKHIFDRCIRDFLSNKIR--ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS 663
            |.||:|.|:..|:....|.:.|.:..|  :||||::|||...:.::.|..|.|..:|:.::.|||
Mouse   862 PFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRS 926

  Fly   664 RQFQFLEQ----TQHDESGIDTHSVSSYLSRSDSE---KSMEHQHNQLLRPDEHVEDV--NQEQQ 719
             :.|..|.    ....:..::..:|....:...|:   ::|..:...||..||..|:.  ::|..
Mouse   927 -ECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDD 990

  Fly   720 TVGSIKMHVYA-----SYIKALDSTFLLGIVISLFVCARIM----LTGVDYFLSRWVIWEEQIAV 775
            .:.|: :|..|     :..|.|.|..:|  ::||.|.::::    |..:||:|::|         
Mouse   991 NLSSV-LHQRAKIPWRACTKYLSSAGVL--LLSLLVFSQLLKHMVLVAIDYWLAKW--------- 1043

  Fly   776 NRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVL---FYATI------LGATL 831
                     ||:.:.            ::|...:   ..:.||..|   .||.:      ||..|
Mouse  1044 ---------TDSALV------------LSPAARN---CSLSQECALDQSVYAMVFTVLCSLGIAL 1084

  Fly   832 IVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLL 896
            .  |:.:.......|:::..||..|...|..|.|.||.|...|.||||||.|..|:|..:|.| |
Mouse  1085 C--LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-L 1146

  Fly   897 DCL--AFIIDVSGVVIIVAIANYWL--LIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFS 957
            :||  :.::.||.:.:|..:...:|  |:|.|::...:.  :|..| .||.:::|:..::.|:.|
Mouse  1147 ECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQ--KYFRV-ASRDLQQLDDTTQLPLLS 1208

  Fly   958 LTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV------------- 1009
            ...:|.:|||||||.:.::..:|:..||.::|..| .|||:....   |.:|             
Mouse  1209 HFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIA-SLFLTAANR---WLEVRMPGPAAVLPQEY 1269

  Fly  1010 --LCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERV--LE 1070
              .|:|.:.|.|.....|..|..:|.|||.:.::..::....|.:|..|::|.|:.:|:|:  |.
Mouse  1270 IGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLL 1334

  Fly  1071 YTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTG 1135
            .||..|...|..|... ||: ||.:|:|:..|..:||.....||||.:|..|.|.:||||.||||
Mouse  1335 KTEAESYEGLLAPSLI-PKN-WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTG 1397

  Fly  1136 AGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERS 1199
            :||||...:.||:. ..||.|.||.:||..:.||.|||::|||.|||||||||:|:||||..:.|
Mouse  1398 SGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCS 1462

  Fly  1200 DEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANV 1264
            |..:|:||...:|:..|..|.|||:..:.:||.|||.|||||.|||||.:|...|.|||||||::
Mouse  1463 DSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1527

  Fly  1265 DPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQR 1321
            |..|:.::|:.:.:.||..||:|||||:||::.:|.|:|:..|.:.|...|.:||.:
Mouse  1528 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQ 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 431/1478 (29%)
ABC_membrane 94..360 CDD:294371 72/308 (23%)
ABCC_MRP_domain1 448..650 CDD:213217 80/236 (34%)
ABC_membrane 821..1046 CDD:294371 74/252 (29%)
ABCC_MRP_domain2 1096..1315 CDD:213211 109/219 (50%)
Abcc8XP_036008753.1 MRP_assoc_pro 224..1594 CDD:188098 428/1460 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841694
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.740

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