DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and mrp-8

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_499598.2 Gene:mrp-8 / 190710 WormBaseID:WBGene00003414 Length:1461 Species:Caenorhabditis elegans


Alignment Length:1393 Identity:436/1393 - (31%)
Similarity:703/1393 - (50%) Gaps:185/1393 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDE---LKRS 73
            :.|..|::|.|:..|.|:..|.:.|.:.|||:|.|:...:...||.:..::...::.|   .|..
 Worm   175 QTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLHNLNENATSEWLYTRWRAEFDKEKAGRKSG 239

  Fly    74 NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIV 138
            ..|:|...:|......:.:.|| .::..|...|.|:.|..|:.|.:.:...:|        .||.
 Worm   240 ETSIVWPFIRIQRATIITLTLA-RLTADIVHYLNPILLKQLIDYVSLHDQPLS--------FGIA 295

  Fly   139 I-CMLVPVITFHPFIFYIFQVGTKLRLA------LSGLIYRKVLQVSKSSSNDGLRGRAINILSN 196
            | |::....|... :...:|:....|.|      ||..|..|:|::|.|:.::...|..:|..:.
 Worm   296 IACIMFSCSTTRS-LLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARSNRTAGEILNHAAV 359

  Fly   197 DLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAK--KAAYYRQ 259
            |:.....::.:|.:.|..|.:..|...::...:|.:|:.||..|:.||||....::  |.:..:|
 Worm   360 DIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLSQQKQ 424

  Fly   260 MTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP 324
            |..:  |.|.||.||::.||:|:|:||||:||...|..:|.||||.:|....:...:...:..||
 Worm   425 MKIK--DERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNVCILSRIVDVANAASP 487

  Fly   325 LSVFLALCSYVYLGDP----LTAQKVYTVSSYFNMLNDSMVTFWPMS-----ITFIAEALVSAKR 380
            ..|.:...:...|..|    ||....:...:.||.|..      ||.     |..:.:|.||.||
 Worm   488 FLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQ------PMRMVANLINTLVQARVSNKR 546

  Fly   381 CKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATK 445
            .:.||.|                         ::.::..|:                     |..
 Worm   547 LRQFLND-------------------------EEMERKTEV---------------------ALG 565

  Fly   446 KCVVLKNVSASWDTSDGHAN-CAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEA 509
            ..:|.||.|.:|   .|..| ..::|.|..||...|.|:||.||.||||.|:.:|.|:.:..|..
 Worm   566 NAIVFKNASLNW---KGPQNPPVLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRV 627

  Fly   510 MVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVS 574
            .|.|.|:|..|.||:|..||::||:|..:.:...|.:||..|.|:.|.....:|:.|:|||.|::
 Worm   628 KVGGSIAYVPQHSWIFNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGIT 692

  Fly   575 LSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYL 637
            ||||||||:|||||||:..|||||||||||||.|||:.:||:.|  ...|.:|.|:||||.:||.
 Worm   693 LSGGQKARISLARAVYQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYT 757

  Fly   638 FDVEHLLLMGSGKIMAQGSYQ--------------ELQRSRQFQFLEQTQHDESGI--------- 679
            ..|:.:.::..|:|:..||::              |.:.|.:....|:.:..|:.:         
 Worm   758 KYVDTIYVIEDGQIVQHGSFEDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTPPVPVLEN 822

  Fly   680 -DTHSV--SSYLSRSD---SEKSMEHQHNQLLRPDEHVEDVNQEQQTVGSIKMHVYASYIKAL-- 736
             |..::  ||.:.|::   ||||.:.:... .:.:::||:|.     :|.:|..||..|||.:  
 Worm   823 GDNGAIEKSSQIDRTNSHFSEKSRKSEEKP-QKVEKNVENVQ-----LGRVKKSVYQLYIKTMGI 881

  Fly   737 --DSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINAT 799
              .|.||:     .|:....::.....:||.|.  .|..|:.:.|  |:..|.        :|:|
 Worm   882 FNSSAFLI-----FFIAHFTVMIMRSLWLSDWS--NENAAIKKAT--LSSVDY--------LNST 929

  Fly   800 DPYIAPLLASDIQAGIRQELVLFYATILGATLIV----YLIRTFGFFKMCLRISLHLHDRLFRGI 860
            .....|:       .:...|:: ||...|..:::    :.:.|.|    .||.|..||..|...:
 Worm   930 SSVDGPV-------SVETRLIV-YAGFGGLEMLLLALAFTVLTIG----SLRASYGLHSPLIHAL 982

  Fly   861 TRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAI 925
            ..|.:.||:|..:|||:||.|:|:..:| .|...:..|...:::...::::::|:....|:.||.
 Worm   983 LVAPISFFDTTPTGRIINRLSRDLDVID-KLQDNIRMCTQTLLNACMILVLISISTPIFLVCAAP 1046

  Fly   926 IGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQ-------AQSALEQEFH 983
            :.:|...:...|:.|||.:|||||.:|||:.|...::..|.::|||..       |.|....:|.
 Worm  1047 LILIYYFVMIYYIPTSRQLKRLESANRSPILSTIAESIHGASSIRAFDKTERTTTALSTNVDKFA 1111

  Fly   984 E--YQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEF--DSGDVGLAILHSTTM 1044
            :  |.:..::.|.    .||...|.:  .|:::   .:.|..|....|  ..|..||::.::.|:
 Worm  1112 QCRYLSHMSNRWL----ATRLELLGN--TCVLF---ASLSATLSTKYFGLTPGMAGLSVSYALTI 1167

  Fly  1045 TGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSP 1109
            |.:....:|..:|:|:.:.|||||.||.:...||.....:..:.:.:||.||:||...|.:||..
 Worm  1168 TEVLNICVRSVSEIESNIVSVERVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRYRK 1232

  Fly  1110 KEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNE-GMIRIDDVDIEHIGLHDLRSQ 1173
            ....|||:::..||..|:||::||||:||||:..:::|:...| |.|:||||:|:.||||.|||:
 Worm  1233 NLPLVLKNIDLKIEGGERIGVIGRTGSGKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSK 1297

  Fly  1174 VSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQ 1238
            :.||||:||:||||||:||||.::.||:::|..|...:|:.:.......|:..:.:||.|.|||:
 Worm  1298 LIIIPQEPVVFSGTLRFNLDPFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGE 1362

  Fly  1239 RQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLV 1303
            |||:||.||:||..:|:|:|||||:||..||.::|:.||..|...|.::|||||.|::||||::|
 Worm  1363 RQLLCLCRALLRGARIVILDEATASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVV 1427

  Fly  1304 MDAGEVRELGHPYELLQRTGGYLRQLVD 1331
            :|||.|.|...|..||........||::
 Worm  1428 LDAGRVAEFDTPSNLLLNPDSLYSQLLN 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 436/1393 (31%)
ABC_membrane 94..360 CDD:294371 76/278 (27%)
ABCC_MRP_domain1 448..650 CDD:213217 94/204 (46%)
ABC_membrane 821..1046 CDD:294371 63/239 (26%)
ABCC_MRP_domain2 1096..1315 CDD:213211 107/219 (49%)
mrp-8NP_499598.2 CFTR_protein 173..1459 CDD:273530 436/1393 (31%)
ABC_membrane 259..527 CDD:294371 76/285 (27%)
ABCC_MRP_domain1 568..770 CDD:213217 94/204 (46%)
ABC_membrane 887..1168 CDD:294371 78/319 (24%)
ABCC_MRP_domain2 1219..1439 CDD:213211 107/219 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

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