DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and mrp-3

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1403	Identity:	424/1403 - (30%)
Similarity:	701/1403 - (49%)	Gaps:	200/1403 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPS 76
            |.|...|||.|:....|...:...|.:..|..:::::....:|.|.:..::...|..:.:::...
Worm   192 KCPEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREK 256

  Fly    77 VVRM------------------ILRAYG--------KIFVPMGLAFSISETICKSLM-------- 107
            .|::                  ....||        ::.|...:..::.:.:...::
Worm   257 QVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEILGGSFIKFL 321

  Fly   108 --------PLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRL 164
                    |.||..|:.:..|....:.....  .|:|:.:...:..:..:.:...:.:||.|::.
Worm   322 SDLLQFANPTFLNYLILFIETPNAPLINGIG--LAVGLFLAGQIKSLFMNTYFIAMTRVGAKIQT 384

  Fly   165 ALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREI 229
            .||..:|.|.|.:|.::..:...|..:||||.|:.||.:....:...|..|.:.|:...|:.:.|
Worm   385 MLSCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQTI 449

  Fly   230 GISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARV 294
            |::...|:..|:|.:|:....:.....::....:..|.|::|:||::.||:|:|:.|||.:....
Worm   450 GVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAMEET 514

  Fly   295 IAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSYV--YLGDP---LTAQKVYTVSSYFN 354
            |..||.||:|.|:.:|.:.....|.::.:|  ||:||.|:.  .|.||   ||....:...|.||
Worm   515 IERVRDKELKMIKQSALLKTFADCLNVGAP--VFVALSSFTVFVLIDPKNVLTPNIAFVSLSLFN 577

  Fly   355 MLNDSMVTFWPMSITFIAEA---LVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQ 416
            :|...::    |:...:|:.   :||.||.:.||.:.:.....|                  ||
Worm   578 LLRGPLM----MAAELVAQTVQLVVSNKRVRTFLCEKEVDTAAI------------------DK- 619

  Fly   417 KNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLA 481
               |:.|.|.:|                  .|.:.:.|.:||:::......|| |....|:  |.
Worm   620 ---EIRGELYTN------------------TVEIHSGSFAWDSAEARILSDIE-FLAGSKE--LV 660

  Fly   482 AVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKK 546
            .|||.||:||||.|...|||:....|...|.|.::|.||:.|:...:::.|::...|.|:..|||
Worm   661 TVVGSVGSGKSSLLLAALGEMEKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKK 725

  Fly   547 VVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGK 611
            |::.|.|:.|::.||.||.|.:||:|::||||||||::||||||:..|:|.|||||||||.||||
Worm   726 VIESCALKEDLKQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGK 790

  Fly   612 HIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL-----------QRS 663
            ||||..|  ...||:..|||||:...:|.:...:::|..|:|...|:|.||           :..
Worm   791 HIFDNVIGPNGMLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTYNELLTDVEAREYLQEVD 855

  Fly   664 RQFQFLEQTQHDESG-----------IDTHSVSSYLSRSD--SEKSMEHQHNQLLRPDEHVEDVN 715
            .::...:::..:|||           |.:.|..|.|||..  |.|..:....:..:||..   :.
Worm   856 NEYAQAQESSGEESGGEENSDILPGSIASGSRMSRLSRLSKISRKKSKSSIVEKKKPDAL---IT 917

  Fly   716 QEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSR--WV-IWEE-QIAVN 776
            :|:..:|.:...||..|.||      :|||..:...|..::..|.:.|.|  |: .|.: .|.:|
Worm   918 KEEAAIGRVNPGVYLLYFKA------MGIVTYVLPYAIAVVLNVSFALGRSLWLTAWSDANIDIN 976

  Fly   777 RTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGF 841
            ..             ||:.:.|             :.|:       ||. .|.|.:::|     |
Worm   977 HP-------------DTMSVGA-------------RLGV-------YAG-FGITEVIFL-----F 1002

  Fly   842 FKMCLRI------SLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLA 900
            |.:.|.:      |.:||..|...:.|..:.:|:....|||:||.:||:..||..|..:....:.
Worm  1003 FSLVLLLIGGVAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDMEVVDLRLSSSFRFLVM 1067

  Fly   901 FIIDVSGVVIIVA------IANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLT 959
            .:|::...|:||:      ||   ::||..||  ...:::| .:.::|.::|:.|::|||:||..
Worm  1068 ALINMVQTVLIVSYTTPLFIA---IIIPVFII--YFFVLKY-SIKSTRQLQRIASLTRSPIFSNF 1126

  Fly   960 NQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVL-CIVYMTAVTFSFL 1023
            ::|.||::|:||.|......:...|:.||:....:......|..::..::| .||..:|...:.:
Worm  1127 SETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMANRWLSIRLELLGNIVIFSAAILAII 1191

  Fly  1024 LLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKP 1088
            ..:....:|.:||::.:|..:|.|....:||..|:|..:.||||:.||::..|||.........|
Worm  1192 GKESGITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEAEWRLDNNNLP 1256

  Fly  1089 KSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA-CNE 1152
             |.||:.|.:...::..||..:...|||.::..|.|.:|:|:.|||||||||:..::||:. ..:
Worm  1257 -SNWPTGGAVNIEDYSCRYRDELDLVLKQISLNILPGQKVGVCGRTGAGKSSLALALFRIVEAAD 1320

  Fly  1153 GMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVS 1217
            |.|.||.....||||||||.:::||||:.|||:.|||:|:||..:.:|:::|.||.:..|:::|.
Worm  1321 GNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLALENSNLKAHVE 1385

  Fly  1218 TLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAH 1282
            .|...|...:.:||.|||||||||:||.||:||.:|:|::|||||.:|..||.::|.|||.|||.
Worm  1386 LLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDTMVQATIREKFAD 1450

  Fly  1283 CTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQ 1320
            .|::||||||||::|.||::|||||.:.|.|.|.|||:
Worm  1451 STIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLK 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	424/1403 (30%)
		ABC_membrane	94..360	CDD:294371	70/286 (24%)
		ABCC_MRP_domain1	448..650	CDD:213217	90/203 (44%)
		ABC_membrane	821..1046	CDD:294371	62/237 (26%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	107/219 (49%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	424/1403 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720