DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and mrp-5

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_510479.1 Gene:mrp-5 / 181587 WormBaseID:WBGene00003411 Length:1427 Species:Caenorhabditis elegans


Alignment Length:1462 Identity:437/1462 - (29%)
Similarity:710/1462 - (48%) Gaps:222/1462 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RKVVRPKN----PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEEL----YQHRKTLDSERVTNKF 62
            |...|.||    ....|..||..::.|:.....:.::|.|...::    :.....|:..|:    
 Worm    57 RTTERNKNNGGSRIDDAGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARL---- 117

  Fly    63 AELWEDELKRS--NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVG--------- 116
            ..|||||.|.:  :||:.::|.|     |:...|.||     |.......:.|.:|         
 Worm   118 EVLWEDEKKANAKSPSLFKVIYR-----FISTRLWFS-----CAVFFFCLIFGFIGPTCFIRRLI 172

  Fly   117 YFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFY------IFQVGTKLRLALSGLIYRKVL 175
            .||.| .:..|.:..:|:.||.:...:.|:.|...:.|      .::.|.::|.|:..|:|:.||
 Worm   173 AFAEN-PERDEQSRIVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVL 236

  Fly   176 QVSKSSSNDGLRGR----AINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMY--REIGISAV 234
                 :|.| |.|:    .|||.:||..|...|:.|......||:  :|:|.:.|  ..||..::
 Worm   237 -----NSKD-LCGKTESDVINIFANDGQRLFDAVTFAPLVLVGPL--VLVGGIGYLLMVIGRWSL 293

  Fly   235 IGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVR 299
            :|:.....|..:|....|.....|.:...:|:.|:.:|.|||:.|:::||..||:.|:..|.:.|
 Worm   294 LGILVFFVFDVIQFGLGKSMVACRNLAIVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFR 358

  Fly   300 LKEVKAIRGTAYIHA-ALGCTSMISPLSVFLALCSYVYLGDPLTAQKVYT-VSSYFNMLNDSMVT 362
            .:|...||.:.|..: |:.|..::..::..|.....|..|:.|.|...:: ::.||.||..  :.
 Worm   359 KEEKVQIRKSGYAQSLAIACGPVVPVVAAILTFVGVVLAGNDLLASDAFSAITVYFVMLFG--IR 421

  Fly   363 FWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLS 427
            ..|....::|||:|:.:|.:::||....|..|:.                  ..::|.|:    .
 Worm   422 MIPYGSRYLAEAVVAMRRIQEYLLLEQYAPYPVT------------------NAEDVVLD----C 464

  Fly   428 NGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHAN-----------CAIEDFSTDIKDQTLA 481
            .|..:     .|.|:|.|..|.        :|.:...|           |:.:..|  ||.....
 Worm   465 QGATY-----TYQPKAAKAPVD--------ETKEPTENEVIVVETPVFTCSFDKLS--IKRGEHI 514

  Fly   482 AVVGPVGAGKSSFLNVLLGE-------VGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDY 539
            ||:|.||.|||:.|..:.|.       :.:|:.:.:      |..|::|:|.||::|||:|.:..
 Worm   515 AVIGAVGCGKSAILKAISGHMFTTDDALSVDRSQTV------YVPQKAWIFNGTVQDNILFGDKM 573

  Fly   540 NERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSA 604
            |..||.|.|..|.|..|:..|..||.|.|||||.:|||||||||:|||||::..::||.||..::
 Worm   574 NSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGATLSGGQKARVALARAVFQTKNLYLFDDIFAS 638

  Fly   605 VDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGS----YQELQRSRQ 665
            :|..|...|.:..|:..|..|..::||:.::.|...:.:|.:..|.|:|.|:    |::....:.
 Worm   639 LDKKVANKIHEEIIQKLLKKKALMMVTNNMELLHHFDRVLFVEGGNIVADGNHDILYEKNDAYKT 703

  Fly   666 FQFLEQTQHDESGIDT---------HSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVNQEQQTV 721
            |....:|....||..:         ..:.:.:.|:.|| .::...::|:..:|.:.:        
 Worm   704 FVDACETYQATSGATSPCGDGPAQPAPLDAEILRNSSE-DLKGDADKLISDEEDMGN-------- 759

  Fly   722 GSIKMHVYASYIKA-----LDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTL 781
            .:|...:|..||.|     :.:..::|.:::  |.:.|..|   |:||||:    :...:.|||:
 Worm   760 STIAWRIYKQYIHAAGGWPIWTCLVIGFIVN--VVSNIFST---YWLSRWL----KKGHDETTTI 815

  Fly   782 LNETD-----TTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGF 841
            .|.|:     |::|:.  |:..                       |||.:....|:|..|.  |.
 Worm   816 TNGTEFLEMKTSLADS--PVTG-----------------------FYAAVYLVALVVLTIS--GL 853

  Fly   842 FKMC--LRISL----HLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHT------ 894
            ||.|  :::||    .||||:|:.:...:..||::..:||||||||||:..:|..||.|      
 Worm   854 FKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFSKDMDEIDVKLPFTAEVFLQ 918

  Fly   895 -LLDCLAFIIDVSGVVIIVAIANYWLL--IPAAIIGVILGMIRYLYVNT----SRSVKRLESISR 952
             ::.||.|:      |:|.::..|:||  ||..::.|:       :|:.    .|::||.|.|||
 Worm   919 NMITCLGFL------VVITSVFPYFLLFAIPLFVVFVV-------FVSCFRAGIRNLKRSEHISR 970

  Fly   953 SPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTA 1017
            ||::...:.:.:|:|||...|..:...:...::.:.|:.|.|:|.|..|..|:|.|:|.:|....
 Worm   971 SPLYDHVSASLEGITTIHTFQQSNRFLEVLKKHLDCNSGAIFMFQSAMRWLAVWLDLLVVVMTAI 1035

  Fly  1018 VTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQ-PSEALLE 1081
            |....::|.......|.|:||..:..|:|:.|:.:|...|||.:|||||||..|.:. |.:....
 Worm  1036 VALLTVMLTGTVSPADAGMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYADNIPEDGEWN 1100

  Fly  1082 TPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIF 1146
            |.:....:|.||:.|:|.|....|||.......|.|:.|.|:..||:||:||||:||||:...||
 Worm  1101 TRQGLDIESSWPANGQINFSEVNLRYRKSHPLALNDITFEIKGGEKVGIIGRTGSGKSSLANLIF 1165

  Fly  1147 RL-ACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDV 1210
            || ....|.|.||.|||..:||..||..:|.|.|||.|||||:|:||||..|.||..:|:||...
 Worm  1166 RLYPVTNGTIYIDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDSMIWEALEKC 1230

  Fly  1211 ELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQT 1275
            .|::.|.:|...|...:..||:|||||:|||.|||||:|..::|:|:|||||:||..||||||:.
 Worm  1231 HLKTLVQSLDKKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDAGTDKLIQEV 1295

  Fly  1276 IRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFA 1340
            |::.||..||:.|||||..|.:.||::.:..|::.....|.|:.:......:....:....::..
 Worm  1296 IKTVFADATVIIIAHRLDNVRNMDRIMHLKNGKLINFTTPQEMFKDDWSVYKLEDKDDDQHSAVV 1360

  Fly  1341 LQQAAEQSYSKQILGDDTAAEDLNITLAMEEK 1372
            :.:.:|.|..|...|....::|: :.:..|:|
 Worm  1361 VGENSEHSMEKSSQGSSQESDDI-VKVENEQK 1391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 428/1425 (30%)
ABC_membrane 94..360 CDD:294371 76/288 (26%)
ABCC_MRP_domain1 448..650 CDD:213217 73/219 (33%)
ABC_membrane 821..1046 CDD:294371 77/243 (32%)
ABCC_MRP_domain2 1096..1315 CDD:213211 107/219 (49%)
mrp-5NP_510479.1 MRP_assoc_pro 90..1340 CDD:188098 422/1375 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 142 1.000 Domainoid score I2904
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1827
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.780

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