Protein Alignment rdog and pgp-14

DIOPT Version :9

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_510128.1
• Gene: pgp-14 / 181416
• WormBaseID: WBGene00004008
• Length: 1327
• Species: Caenorhabditis elegans
• Alignment Length: 1451
• Identity: 298/1451 - (20%)
• Similarity: 567/1451 - (39%)
• Gaps: 363/1451 - (25%)

  Fly    72 RSNPSVVRMILRAY-------GKIFVPMGLAFSISETICK--------SLMPLFLGGLVGYFATN 121
            :|:|.:...:...|       .|::.|..|...::..:|:        ...|:.:.||..|
 Worm    36 KSDPKIASDLPANYVDDDDDAPKMYTPSLLEKILNYALCRGDIANQQLEAQPVSIPGLFRY---- 96

  Fly   122 QTDISENTAYLYAMGIVICMLVPVITFHPFI----------------------------FYIFQV 158
                .:...||......||.::..:: .|.:                            .||| :
 Worm    97 ----GKKFDYLLLFIGTICAIISGVS-QPILALVSGRVTNALLVYPPTSKQFRNKANENVYIF-L 155

  Fly   159 GTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAI-NILSNDLGRFD-----VALCFLHDTWKGPME 217
            |..:.::::..|.....|...:.....:|.|.: ::|..:.|.||     .....|:|:.:...|
 Worm   156 GIGIFISITNFIQYMCFQHCCTRVMAQMRHRFVYSVLRQNAGWFDKNHSGTITTKLNDSMERIRE 220

  Fly   218 SI-------LIGFLMYREIGISAVIG--------VSFMLSFIPLQAWAAKKAAYYRQMTAERTDM 267
            .|       |.||.|.    |:|::.        .|.||...|.........|  ||||:.....
 Worm   221 GIGDKLGVLLRGFAML----IAAIVVAYIYEWRLASMMLGVAPTCCICMSLLA--RQMTSTTIKE 279

  Fly   268 RV------KLMNEIIQGIQVIKMY-AWEKSFARVIAEVRLKEVKAI-RG----------TAYIHA 314
            .:      .:..|.:.|::.::.: ..|:...|..||:......|: :|          ..::.:
 Worm   280 LIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFFGGLFFFWLFS 344

  Fly   315 ALGCTSM-----------ISPLSVFLALCSYVYLGDPLTAQKVYTVSSYF-NMLNDSMVTFWPMS 367
            .|||..:           .:|..||:.:.|.:             :.:|| .:::..|:.
 Worm   345 FLGCGMLYGAYLLKVGIITTPGDVFIVVMSML-------------LGAYFLGLISPHMMV----- 391

  Fly   368 ITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVH 432
               :..|.|||......:   |:  || .::...:.||..:.:..:.|.:||
 Worm   392 ---LLNARVSAASIYQTI---DR--VP-KIDPYSKAGKRLQNVVGRVKFENV------------- 434

  Fly   433 HNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNV 497
            |.|.     .:.|...:|..:           |..:|       ..|..|:||..|.|||:.:.:
 Worm   435 HFRY-----PSRKDAKILNGL-----------NLVVE-------PGTSVALVGHSGCGKSTSVGL 476

  Fly   498 L-------LGEVGIDKGEA------MVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVK 549
            |       .|.|.||..:.      .:...:....||..:|..||.:|::.....:.|  :.:::
 Worm   477 LTRLYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTR--ETMIE 539

  Fly   550 VCGLERD---MELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGK 611
            ||.:...   :|.:|:|..|::|:.||.||||||.||::||.:.|...:.|||:..||:|.. .:
 Worm   540 VCKMANAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQ-SE 603

  Fly   612 HIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR----------SRQF 666
            .|....:.:....:..|::.|::..:.:.:.::....|.|:..|:::||.|          ::||
 Worm   604 SIVQSALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQF 668

  Fly   667 ----QFLEQTQHDESGIDTHSVSSYLS-----RSDSE-----------------KSMEHQHNQLL 705
                :..|:.:.:|..:|..|.||..|     ||.||                 .:.....|...
 Worm   669 KADPEATEEFEEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAF 733

  Fly   706 RPDEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFL---LGIVISLFVCARIMLTGVDY----FL 763
            ..:|........|.|.|      |....|.....:|   ||.|.:|       :.|::.    .:
 Worm   734 AANEAAIMAEDGQITAG------YLDIFKNAKGNYLYMFLGTVFAL-------IRGLELPALALI 785

  Fly   764 SRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILG 828
            ..||.               |..|.:           ||...::.....|      |:.:|::..
 Worm   786 FGWVF---------------EGFTFV-----------PYGGRMMHRMAMA------VIAFASVGV 818

  Fly   829 ATLIVYLIRTFGFFKMCLRISLHLHDRLFRGIT-RASMYFFN-TNSSGRILNRFSKDIRTVDTDL 891
            ......|..:..|..:...:|:....:.||.:. :.:.||.| .::.|:::.|.:.|...:...:
 Worm   819 GVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLYQDASYFDNPAHAPGKLITRLASDAPNIKAVV 883

  Fly   892 PHTLLDCLAFIIDVSGVVIIVAIANYW------------LLIPAAIIGVI--LGMIRY------- 935
            ...:|.   .|..::.::..:|||..:            ||:...:||:.  :.::..
 Worm   884 DARMLQ---VIYALAAIIANIAIAFIYCWQIGILGTSLILLLAFVMIGLAYKISLMNVEQIQNDD 945

  Fly   936 ---LYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFL 997
               :.:....:||.::.::|..:|      |....|....|.:|.|::...|..|.:.:..|::.
 Worm   946 AGRIAIEIIENVKTIQLLTRCELF------FDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYF 1004

  Fly   998 SCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQM 1062
                       ::|..|...:.   ::.:.:..|.|         |..|:....:...|    .|
 Worm  1005 -----------MMCFTYAVGIR---IIYQGDKSSDD---------TFKGIIAMMLGAVA----VM 1042

  Fly  1063 TSVERVLEYTEQPSEA-LLETPEKFKPKS------EWPS-KGRIEFINFKLRYSPKE-APVLKDL 1118
            .|.:...|:.:..:.| :|......||::      :.|. :|.|.|.|.|..|..:. .|::|.|
 Worm  1043 NSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDRPEIRGNILFENVKFSYPQRPLQPIMKGL 1107

  Fly  1119 NFTIEPREKIGIVGRTGAGKSSIIQSIFRL-ACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPV 1182
            .:|....:.:.:||.:|:|||:.|..:.|. ....|.:|||..||..:.|..||:|::::.|:|.
 Worm  1108 QWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALVGQEPR 1172

  Fly  1183 LFSGTLRYNL------DPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQL 1241
            ||:||:|.|:      .|:     |::.:||.......:::.|..|::..:.:.|...|.||:|.
 Worm  1173 LFAGTIRENVCLGLKDVPL-----EKINQALELANANRFLANLPAGIDTDVGEKGGQLSGGQKQR 1232

  Fly  1242 VCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDA 1306
            :.:|||::|..|||::||||:.:|.|:::.:|:.:.......|.:||||||.::.:||.::.:|.
 Worm  1233 IAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLIVYIDK 1297

  Fly  1307 GEVRELGHPYELLQRTGGYLR 1327
            |:|:|.|:..:|:.:.|.|.:
 Worm  1298 GKVQEAGNHTQLMHQKGRYYK 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	298/1451 (21%)
		ABC_membrane	94..360	CDD:294371	59/352 (17%)
		ABCC_MRP_domain1	448..650	CDD:213217	52/217 (24%)
		ABC_membrane	821..1046	CDD:294371	38/250 (15%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	75/226 (33%)
pgp-14	NP_510128.1	PTZ00265	104..1321	CDD:240339	285/1375 (21%)
		ABC_membrane	109..377	CDD:279056	49/288 (17%)
		ABC_MTABC3_MDL1_MDL2	429..666	CDD:213216	64/275 (23%)
		ABC_membrane	769..1039	CDD:294371	50/340 (15%)
		ABC_MTABC3_MDL1_MDL2	1086..1323	CDD:213216	77/238 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000