Protein Alignment rdog and pgp-12

DIOPT Version :9

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_510126.1
• Gene: pgp-12 / 181415
• WormBaseID: WBGene00004006
• Length: 1318
• Species: Caenorhabditis elegans
• Alignment Length: 1459
• Identity: 288/1459 - (19%)
• Similarity: 569/1459 - (38%)
• Gaps: 366/1459 - (25%)

  Fly    42 TDEE---LYQHRKTLDSERVTNKFAELWEDELKRSNPSVVRMILRAYGKIFVPMGLAFSISE--- 100
            :|||   :|:..|   .|::.|..  |...:|.....||..:.|         :|| |..:|
 Worm    40 SDEEPKIVYEPSK---MEKLINYM--LCRGDLASRELSVKPVTL---------LGL-FRYAERTD 89

  Fly   101 --TICKSLMPLFLGGL----VGYFATNQT--------------DISENTAYLY-AMGIVICMLVP 144
              .:|..:...|:.|:    :|..|.|.|              |.:....:|: .:||:: ::|.
 Worm    90 YALLCFGIFLSFISGIAQPGLGIIAGNITNSLLIHNATSDDFYDSAMTNVWLFGGIGIIV-LIVN 153

  Fly   145 VITFHPFIFYIFQVGTKLRLAL----------------SGLIYRKVLQVSKSSSNDGLRGRAINI 193
            .:.:..|.:...::.:|::...                ||.:..| |..:....|:|: |..:.:
 Worm   154 FVQYMCFQYCCIRITSKMKQHYIQSILRQNAGWFDKNHSGTLTTK-LHDNMERINEGI-GDKLGV 216

  Fly   194 LSNDLGRF--DVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAY 256
            |...:..|  .:.:.|.:: |:       :..:|   :||..:..|...|....:.::.:|:.|.
 Worm   217 LIRGMVMFVAGIVISFFYE-WR-------LALMM---MGIGPLCCVCMSLMSRSMSSFTSKELAG 270

  Fly   257 YRQ--MTAERTDMRVKLMNEIIQGIQVIKMYAWE----KSFARVIAEVRLKEVKAIRGTAYIHAA 315
            ..:  ..||.:.|.|:.:.......::::.|..|    ||||         ..|.:.|..:
 Worm   271 VGKAGSIAEESLMGVRTVQAFNGQEEMVEKYTVELGKGKSFA---------IQKGLWGGVF---- 322

  Fly   316 LGCTSMISPLSVFLA-LCSY----VYLGDPLTAQKV-------------YTVSSYF-NMLNDSMV 361
             |        .:||. |.||    :|.|..|...|:             ..:.:|| .:::..::
 Worm   323 -G--------GIFLLFLFSYFGGGIYYGGQLLRWKIIETPGDVFIVVISMLIGAYFLGLISPHLM 378

  Fly   362 TFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVEL---NG 423
            .        :..|.|:|....:.:                            |:..::::   .|
 Worm   379 V--------LLNARVAAATIYEII----------------------------DRTPDIDVYSTEG 407

  Fly   424 SLLSN--GQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGP 486
            ..::|  |:|....:....| ..||..||..::.:                  :|..|..|:||.
 Worm   408 QKMTNVVGKVVFEEVHFRYP-TRKKVKVLNGLNLT------------------VKPGTSVALVGH 453

  Fly   487 VGAGKSSFLNVLLGEVGIDKGEAMVHGK-------------ISYASQESWVFEGTIRDNIVFVED 538
            .|.|||:.:.:|......:.|:.|:.|:             :....||..:|..||.:|::....
 Worm   454 SGCGKSTSVGLLTRLYEPEGGKVMIDGQDVRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNP 518

  Fly   539 YNERRYKKVVKVCGLERD---MELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDD 600
            ...|  :.:::||.:...   ::.:|.|..|::|:..|.||||||.||::||.:.|...:.|||:
 Worm   519 SATR--EDMIRVCKMANAHDFIQKMPNGYETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDE 581

  Fly   601 PLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL----- 660
            ..||:|.. .:.:....:.:....:..|::.|::..:.:.:.::...:|.|:..|:::||
 Worm   582 ATSALDAQ-SESVVQSALNNAAKGRTTIMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGG 645

  Fly   661 --------QRSRQFQFLEQT--QHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPD------- 708
                    |:.::...:|..  :|:|   :|.:|..:...|..:.|.......|...|
 Worm   646 RYAKLVEAQKFKESDDIEDNGDEHEE---ETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYAS 707

  Fly   709 --------------------EHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCAR 753
                                |.|:.|.:|...:.|    .|....|.....:|...|.:.|.
 Worm   708 TFNTFTLKTAQEEIENEDFAEEVQRVMEEDGVINS----GYLDIFKNAQGNYLYLSVGTFFA--- 765

  Fly   754 IMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQE 818
             :|.|.:..|                 |.|......|....|.:.....:..:....:..|
 Worm   766 -ILRGSELAL-----------------LANMFGFVFAAFKEPEDEMVKALGLIFILYVALG---- 808

  Fly   819 LVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFN--TNSSGRILNRFS 881
            |.:|...::..||...:....|         |....:.|:.:......||:  .::.|:::.|.:
 Worm   809 LFVFITQVISGTLFTIVAENLG---------LKFRVQSFKNLLYQDASFFDNPAHAPGKLITRLA 864

  Fly   882 KDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVIL---GMIRYLYVNTSRS 943
            .|...|...:...:|..:..|..:: :.:|......|.:..|..|.::|   .||...|.....:
 Worm   865 SDAPNVKAVVDTRMLQVIYSITSIT-INLITGYIFCWRIAIAGTIMIVLFATMMISMAYKIAREN 928

  Fly   944 VKR-------------LESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFL 995
            :|:             :||:....:.:.|.:........:.:|.:|.:.:.:.:..|...|..|:
 Worm   929 LKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDAQLVQHKSEMRKSYIQSVNNAISQTFM 993

  Fly   996 FLSCTRAFALWSDVLCIVYMTAVTFSFLL-LKDEFDS------GDVGLAILHST----------T 1043
            :      ||::   :|....|.:.:..:: .:..|.:      |.|  |::||:          |
 Worm   994 Y------FAMF---VCYGVGTPLMYHGIVEAEPTFRAINCMMMGSV--AVMHSSHNFPEFVKAKT 1047

  Fly  1044 MTGM---CQWGMRQTAE-LENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFK 1104
            ..||   ..:...:|.: :|...|.:                             :|.:.|.:.|
 Worm  1048 AAGMLFKLIYRKSKTGDVMEGNNTEI-----------------------------RGNVLFESVK 1083

  Fly  1105 LRYSPKE-APVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRL-ACNEGMIRIDDVDIEHIGL 1167
            ..|..:. .||:.||:|:....:.:.:||.:|.|||:.|..:.|. ..:.|.:|||..:|:.:.|
 Worm  1084 FSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSLSL 1148

  Fly  1168 HDLRSQVSIIPQDPVLFSGTLRYNL-DPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGG 1231
            |.||:|::::.|:|.||:||::.|: ..:.:.|.|::.:||.......:::.|..|::..:.:.|
 Worm  1149 HHLRTQMALVGQEPRLFAGTIKENVCFGLKDVSVEKVHQALELANASRFLANLPAGIDTEVGEKG 1213

  Fly  1232 SNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVM 1296
            ...|.||:|.:.:|||::|..|||::||||:.:|.|:::.:|:.:.......|.:||||||.::.
 Worm  1214 GQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQ 1278

  Fly  1297 DSDRVLVMDAGEVRELGHPYELLQRTGGY 1325
            :||.::.:|.|.|:|.|:...|:...|.|
 Worm  1279 NSDLIVYIDHGMVQEAGNHAHLMSLRGKY 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	288/1459 (20%)
		ABC_membrane	94..360	CDD:294371	59/332 (18%)
		ABCC_MRP_domain1	448..650	CDD:213217	48/217 (22%)
		ABC_membrane	821..1046	CDD:294371	42/259 (16%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	73/221 (33%)
pgp-12	NP_510126.1	ABC_membrane	97..332	CDD:279056	47/270 (17%)
		PTZ00265	145..1312	CDD:240339	263/1339 (20%)
		ABC_MTABC3_MDL1_MDL2	417..654	CDD:213216	57/258 (22%)
		ABC_membrane	762..1005	CDD:294371	44/286 (15%)
		ABC_MTABC3_MDL1_MDL2	1077..1314	CDD:213216	75/231 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910