DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and mrp-6

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001362008.1 Gene:mrp-6 / 180691 WormBaseID:WBGene00003412 Length:1415 Species:Caenorhabditis elegans


Alignment Length:1424 Identity:459/1424 - (32%)
Similarity:739/1424 - (51%) Gaps:164/1424 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 FSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKF-AELWEDELKRSNPSVVRMILRA 84
            ||...|:|.|   .|..|   ||.:|.:.    .|:.::.|: |:..|.:...|.|.....::..
 Worm    59 FSFVGFYWWR---TRNAQ---TDTDLLEK----PSKGISAKYAAQKLESKWISSGPKRTHFLVGV 113

  Fly    85 Y--GKIFVPMGLAFSIS---ETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVP 144
            :  .|:.|   :|.:||   |.:.:...||.|..|:.|:     ||.|...:.|...:.:.:::.
 Worm   114 WHCTKVSV---MAHAISLCLEELTRVAQPLLLRELMSYY-----DIEEGQEFPYWPAMQVALIIS 170

  Fly   145 VITF------HPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDV 203
            :::|      ||:...:.:||...|:|...|:|||.|::|.:|..:...|:.|.:|:.|..:.:.
 Worm   171 LLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQIIQLLNTDAAKLEQ 235

  Fly   204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268
            |..|.|..|..|:......::::...|...::|...|::.:..|...:.:....|:...::.|.|
 Worm   236 AFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQLGVNRRNIGDKMDSR 300

  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTA--YIHAALGCTSMISPLSVFLAL 331
            :|:|:|||.||:||||:.||.:||..|..:|..|:||: ||:  |....:|...:.:.:.:|:.:
 Worm   301 LKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAV-GTSAFYSSMVMGIYFISAKIGLFVYI 364

  Fly   332 CSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPIN 396
            .:..|..:.||.:.|:..|:.||.:......|.|:.:.|..|...:::|...|....:.:.:.:.
 Worm   365 FACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRRIDLFFCLEEYSRITLE 429

  Fly   397 LEA--------NQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKC------ 447
            |::        |::.|...:||.:|                           |..|.||      
 Worm   430 LDSTDTEDGSKNEKEGLTLKKIGEK---------------------------PSWTLKCDKAEKT 467

  Fly   448 -VVLKNVSASWDTSDGHAN------------------------------CAIEDFSTDIKDQTLA 481
             |.|..|:|.|...|.|..                              .|::|.|.:....|..
 Worm   468 SVFLNKVTAVWYDKDEHDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCY 532

  Fly   482 AVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKK 546
            .::|.||:||||.|..:|.|..:.:|...|:|..:|.:||.|:|.|:|:|||||..::|:.||:.
 Worm   533 GIIGSVGSGKSSLLLTILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYEN 597

  Fly   547 VVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGK 611
            .:::|.|..|:.....||:|:||:.|.:|||||:|||:||||||..||||||||||||||.||||
 Worm   598 ALELCLLTPDLRQFANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGK 662

  Fly   612 HIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFLE------ 670
            .:::..||.|||:|:.||||||:.:|.:::.::||.:.|::..||..||:.:....|::      
 Worm   663 KLYENLIRGFLSDKLVILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKSTFTDDFIKLQAVET 727

  Fly   671 QTQHDESGIDTHSVS---SYLSRSDSEK----SMEHQHNQLL-----RPDEHVEDVNQEQQTVGS 723
            :.|.||..:|....|   |.::....||    |:..:.|.:|     ...|:|:::..|.:..|:
 Worm   728 EVQSDELFVDGPPSSPPPSPVNIESMEKINKESIFQRANSVLSGSKMSETEYVKEIVYESRKSGT 792

  Fly   724 IKMHVYASYIKALDSTFLLGIVISLFVC---ARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNET 785
            |...||..|.:.:.:....|  |.|.||   .::|...||::|::|::..:          :|..
 Worm   793 ISWSVYWEYTRGVINPLKYG--IWLVVCVLITQLMNNFVDWWLNKWLVDLD----------MNNA 845

  Fly   786 DTTIANDTLPINATDPYIAPLLASDIQAGIR-QELVLFYATILGATLIVYLIRTFGFFKMCLRIS 849
            |.:.:.:....|      ..:|........: .||....:|::.:  |:.::|:..|....|..|
 Worm   846 DNSTSKEEFNRN------VDVLGYTFNVTFQTYELTFIISTVIMS--ILGVVRSVWFRNAQLMAS 902

  Fly   850 LHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAI 914
            ..||:.:|..:.:....||:.||.|.|||||||||...|..|..|..:.:...:...|:|.:|::
 Worm   903 RILHNSMFDCVLKTESEFFDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSM 967

  Fly   915 ANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALE 979
            ....:::..|.|.......|.:||:.||.:||:|:.:|||:.:....|..||:||||.:.::.:.
 Worm   968 VRPIVILACAFITAGFYFCRKMYVHRSRELKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMI 1032

  Fly   980 QEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTM 1044
            ::|....:...:|:.:.|...|.|.:..|.|..|:::.|....:|..:....|:|||.::.:..:
 Worm  1033 EKFCALHDVYMAAYNMGLLSARWFGICIDFLVSVFVSIVAIVVVLQYETLTVGEVGLCLVCAVQL 1097

  Fly  1045 TGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETP-EKFKPK---SEWPSKGRIEFINFKL 1105
            :|...|.|||:|||||.|.|||||||||:..||.....| :.:..|   :.||:||.|||.|..:
 Worm  1098 SGFFSWIMRQSAELENGMVSVERVLEYTKLKSEEEARRPHDAYLDKQLLNSWPTKGEIEFENVSV 1162

  Fly  1106 RYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA--CNEGMIRIDDVDIEHIGLH 1168
            .|.  |..|||:|:|.:...:|||:|||||||||::|:.||.|.  |: |.:.||.||::||.|:
 Worm  1163 NYG--ETKVLKNLSFVVLGGQKIGVVGRTGAGKSTLIKIIFGLKEYCS-GRVTIDGVDLDHISLN 1224

  Fly  1169 DLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSN 1233
            ..|..:|||||:||:||||:|.||||.||..|..:|.||...||:..: |...|||..:...|.:
 Worm  1225 FRRGGMSIIPQEPVIFSGTVRENLDPFDEYDDATIWFALEQCELKRSI-TKEKGLNVELGQRGVS 1288

  Fly  1234 FSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDS 1298
            .|||||||.|||||::..:|||::||||||||..||..||:|||..|.:.|::|:||||||:|:|
 Worm  1289 LSVGQRQLFCLARAMIHRSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNS 1353

  Fly  1299 DRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAA-------EQSYS 1350
            |.|:|.:.||:.|...|..||........::...:||....:|:.||       :.||:
 Worm  1354 DNVMVFEKGELVEFDKPITLLDDQSSLFSRMAAQSGAENFDSLRAAALAHAIDDQSSYT 1412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 455/1408 (32%)
ABC_membrane 94..360 CDD:294371 75/276 (27%)
ABCC_MRP_domain1 448..650 CDD:213217 95/231 (41%)
ABC_membrane 821..1046 CDD:294371 63/224 (28%)
ABCC_MRP_domain2 1096..1315 CDD:213211 114/220 (52%)
mrp-6NP_001362008.1 MRP_assoc_pro <126..1389 CDD:188098 433/1319 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I2739
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.830

Return to query results.
Submit another query.