Protein Alignment rdog and mrp-6

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001362008.1
• Gene: mrp-6 / 180691
• WormBaseID: WBGene00003412
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1424
• Identity: 459/1424 - (32%)
• Similarity: 739/1424 - (51%)
• Gaps: 164/1424 - (11%)

  Fly    21 FSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKF-AELWEDELKRSNPSVVRMILRA 84
            ||...|:|.|   .|..|   ||.:|.:.    .|:.::.|: |:..|.:...|.|.....::..
 Worm    59 FSFVGFYWWR---TRNAQ---TDTDLLEK----PSKGISAKYAAQKLESKWISSGPKRTHFLVGV 113

  Fly    85 Y--GKIFVPMGLAFSIS---ETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVP 144
            :  .|:.|   :|.:||   |.:.:...||.|..|:.|:     ||.|...:.|...:.:.:::.
 Worm   114 WHCTKVSV---MAHAISLCLEELTRVAQPLLLRELMSYY-----DIEEGQEFPYWPAMQVALIIS 170

  Fly   145 VITF------HPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDV 203
            :::|      ||:...:.:||...|:|...|:|||.|::|.:|..:...|:.|.:|:.|..:.:.
 Worm   171 LLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQIIQLLNTDAAKLEQ 235

  Fly   204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268
            |..|.|..|..|:......::::...|...::|...|::.:..|...:.:....|:...::.|.|
 Worm   236 AFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQLGVNRRNIGDKMDSR 300

  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTA--YIHAALGCTSMISPLSVFLAL 331
            :|:|:|||.||:||||:.||.:||..|..:|..|:||: ||:  |....:|...:.:.:.:|:.:
 Worm   301 LKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAV-GTSAFYSSMVMGIYFISAKIGLFVYI 364

  Fly   332 CSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPIN 396
            .:..|..:.||.:.|:..|:.||.:......|.|:.:.|..|...:::|...|....:.:.:.:.
 Worm   365 FACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRRIDLFFCLEEYSRITLE 429

  Fly   397 LEA--------NQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKC------ 447
            |::        |::.|...:||.:|                           |..|.||
 Worm   430 LDSTDTEDGSKNEKEGLTLKKIGEK---------------------------PSWTLKCDKAEKT 467

  Fly   448 -VVLKNVSASWDTSDGHAN------------------------------CAIEDFSTDIKDQTLA 481
             |.|..|:|.|...|.|..                              .|::|.|.:....|..
 Worm   468 SVFLNKVTAVWYDKDEHDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCY 532

  Fly   482 AVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKK 546
            .::|.||:||||.|..:|.|..:.:|...|:|..:|.:||.|:|.|:|:|||||..::|:.||:.
 Worm   533 GIIGSVGSGKSSLLLTILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYEN 597

  Fly   547 VVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGK 611
            .:::|.|..|:.....||:|:||:.|.:|||||:|||:||||||..||||||||||||||.||||
 Worm   598 ALELCLLTPDLRQFANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGK 662

  Fly   612 HIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQFQFLE------ 670
            .:::..||.|||:|:.||||||:.:|.:::.::||.:.|::..||..||:.:....|::
 Worm   663 KLYENLIRGFLSDKLVILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKSTFTDDFIKLQAVET 727

  Fly   671 QTQHDESGIDTHSVS---SYLSRSDSEK----SMEHQHNQLL-----RPDEHVEDVNQEQQTVGS 723
            :.|.||..:|....|   |.::....||    |:..:.|.:|     ...|:|:::..|.:..|:
 Worm   728 EVQSDELFVDGPPSSPPPSPVNIESMEKINKESIFQRANSVLSGSKMSETEYVKEIVYESRKSGT 792

  Fly   724 IKMHVYASYIKALDSTFLLGIVISLFVC---ARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNET 785
            |...||..|.:.:.:....|  |.|.||   .::|...||::|::|::..:          :|..
 Worm   793 ISWSVYWEYTRGVINPLKYG--IWLVVCVLITQLMNNFVDWWLNKWLVDLD----------MNNA 845

  Fly   786 DTTIANDTLPINATDPYIAPLLASDIQAGIR-QELVLFYATILGATLIVYLIRTFGFFKMCLRIS 849
            |.:.:.:....|      ..:|........: .||....:|::.:  |:.::|:..|....|..|
 Worm   846 DNSTSKEEFNRN------VDVLGYTFNVTFQTYELTFIISTVIMS--ILGVVRSVWFRNAQLMAS 902

  Fly   850 LHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAI 914
            ..||:.:|..:.:....||:.||.|.|||||||||...|..|..|..:.:...:...|:|.:|::
 Worm   903 RILHNSMFDCVLKTESEFFDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSM 967

  Fly   915 ANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALE 979
            ....:::..|.|.......|.:||:.||.:||:|:.:|||:.:....|..||:||||.:.::.:.
 Worm   968 VRPIVILACAFITAGFYFCRKMYVHRSRELKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMI 1032

  Fly   980 QEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTM 1044
            ::|....:...:|:.:.|...|.|.:..|.|..|:::.|....:|..:....|:|||.::.:..:
 Worm  1033 EKFCALHDVYMAAYNMGLLSARWFGICIDFLVSVFVSIVAIVVVLQYETLTVGEVGLCLVCAVQL 1097

  Fly  1045 TGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETP-EKFKPK---SEWPSKGRIEFINFKL 1105
            :|...|.|||:|||||.|.|||||||||:..||.....| :.:..|   :.||:||.|||.|..:
 Worm  1098 SGFFSWIMRQSAELENGMVSVERVLEYTKLKSEEEARRPHDAYLDKQLLNSWPTKGEIEFENVSV 1162

  Fly  1106 RYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA--CNEGMIRIDDVDIEHIGLH 1168
            .|.  |..|||:|:|.:...:|||:|||||||||::|:.||.|.  |: |.:.||.||::||.|:
 Worm  1163 NYG--ETKVLKNLSFVVLGGQKIGVVGRTGAGKSTLIKIIFGLKEYCS-GRVTIDGVDLDHISLN 1224

  Fly  1169 DLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSN 1233
            ..|..:|||||:||:||||:|.||||.||..|..:|.||...||:..: |...|||..:...|.:
 Worm  1225 FRRGGMSIIPQEPVIFSGTVRENLDPFDEYDDATIWFALEQCELKRSI-TKEKGLNVELGQRGVS 1288

  Fly  1234 FSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDS 1298
            .|||||||.|||||::..:|||::||||||||..||..||:|||..|.:.|::|:||||||:|:|
 Worm  1289 LSVGQRQLFCLARAMIHRSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNS 1353

  Fly  1299 DRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAA-------EQSYS 1350
            |.|:|.:.||:.|...|..||........::...:||....:|:.||       :.||:
 Worm  1354 DNVMVFEKGELVEFDKPITLLDDQSSLFSRMAAQSGAENFDSLRAAALAHAIDDQSSYT 1412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	452/1388 (33%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	433/1319 (33%)