DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and mrp-1

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1421	Identity:	453/1421 - (31%)
Similarity:	707/1421 - (49%)	Gaps:	210/1421 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KN--PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELW-------- 66
            ||  |...|:|.:|.:|.|...|...|.:..|..|:|:...:...:|.:...|.|..
Worm   204 KNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYR 268

  Fly    67 -------EDELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTD 124
                   |..:.:::||::..|.:.| |..:..|..:.:...:.:.:.|..|..|:.:..
Worm   269 RKIKKNPEAAIPKNHPSILIPIFKTY-KFTLLAGGCYKLMFDLLQFVAPELLRQLISFIE----- 327

  Fly   125 ISENTAYLYAMGIVICM----LVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDG 185
             .:|......:.|.:.|    |:..:..|.:...:|::|..:|..|:..:|.|.|.:|..:....
Worm   328 -DKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGK 391

  Fly   186 LRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWA 250
            ..|..:|::|.|:.|......|:...|..|::.:|..:.:::.:|:|.:.|...::..||..::.
Worm   392 TTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFI 456

  Fly   251 AKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAA 315
            :.|....:....:..|.|:|:|:||:.|::|:|:|:||||..:::.|||.||::.::..:|::||
Worm   457 SVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAA 521

  Fly   316 LGCTSMISPLSVFLALCSYVYLGDP----LTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALV 376
            ...:...:|..|.:.......|.||    ||.|..:...:.||:|...:..| .|..:...:...
Worm   522 TTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVF-AMVFSQAVQCSA 585

  Fly   377 SAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDP 441
            |..|.|:|.    .||     |.:.||                    |:...|
Worm   586 SNTRLKEFF----AAE-----EMSPQT--------------------SIAYGG------------ 609

  Fly   442 EATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDK 506
              |...:.:...|.:|.:.:  .:..:.|.:.:||...|.|:||.||:||||.|:.||||:....
Worm   610 --TDSAIKMDGGSFAWGSKE--EDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLS 670

  Fly   507 GEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGER 571
            |...|:|.::|..|.:|:...::|:||:|...|:.:.|:.|::.|.|.:|:|.||..|.|.:||:
Worm   671 GSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEK 735

  Fly   572 GVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCI---RDFLSNKIRILVTHQ 633
            |::||||||.|||||||||:.|:|.||||||||||:|||||||:..|   ...|..|.|:|:||.
Worm   736 GINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHG 800

  Fly   634 VQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQ--FQFLEQTQHDES---------GIDTHSVSSY 687
            :.||...:.::::....|...|:||||..|..  .:|||:...:||         |.|:..|:..
Worm   801 LTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNEL 865

  Fly   688 L-----------SRSDSEKSME----------------HQHNQ-----------------LLRPD 708
            |           .|..|:.|.|                |:..|                 .:.|.
Worm   866 LRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPK 930

  Fly   709 EHVED---------VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISL-----FVCARIMLTGV 759
            |...:         :.:|....|.:|..||.||.:|      :||.|:|     :|.:.::....
Worm   931 EKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRA------IGIKIALVFFLVYVASSMLGVFS 989

  Fly   760 DYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYA 824
            :.:|:||....::||::...:         :::|                .|:.||...|.:..|
Worm   990 NLYLARWSDDAKEIALSGNGS---------SSET----------------QIRLGIYAVLGMGQA 1029

  Fly   825 TILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDT 889
            |.:.|..|:..:.     .:|  .|..||..|...|.|:.|.||:....|||||||.||:..|||
Worm  1030 TSVCAASIIMALG-----MVC--ASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDT 1087

  Fly   890 DLPHTLLDCLAFI-IDVSGVVIIVAIANYW-------LLIPAAIIGVILGMIRYLYVNTSRSVKR 946
            |:|.|:   ..|| ..||.:.||..|  .|       ||:|..|:..:  ::|: ||:|||.:||
Worm  1088 DIPRTM---SMFIRTAVSSIEIIAII--LWATPLAISLLLPLFIVYFV--VLRF-YVSTSRQLKR 1144

  Fly   947 LESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVL- 1010
            |||.||||::|...::.||.::|||........:|.....:.|.:.::..:...|..|:..:::
Worm  1145 LESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVG 1209

  Fly  1011 -CIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQ 1074
             .||..:|....:........:|.|||::.::..:|....|.:|.|:|||..:.:|||:.|||..
Worm  1210 NLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTIT 1274

  Fly  1075 PSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKS 1139
            |:|.  ...:...||| ||..|.|...||.:||.|....||..:...|.|.||||||||||||||
Worm  1275 PTEG--NNSQSLAPKS-WPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKS 1336

  Fly  1140 SIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEM 1203
            |:..::|| :..:.|.|.||..:|..:.|..|||:::|:||||||||||:|.||||....||:::
Worm  1337 SLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQI 1401

  Fly  1204 WKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPET 1268
            |:||.:..|.|:|.:|..||:..:.:||.|.|||||||:|||||:||..|:|::|||.|.||.||
Worm  1402 WEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVET 1466

  Fly  1269 DKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGG 1324
            |.|:|:|||.:|..||||||||||:|||||||:||:|.|.|.|...|.:||....|
Worm  1467 DSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDG 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	453/1421 (32%)
		ABC_membrane	94..360	CDD:294371	64/273 (23%)
		ABCC_MRP_domain1	448..650	CDD:213217	87/204 (43%)
		ABC_membrane	821..1046	CDD:294371	73/234 (31%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	121/219 (55%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	453/1421 (32%)
		ABC_membrane	309..570	CDD:294371	64/266 (24%)
		ABCC_MRP_domain1	614..815	CDD:213217	87/202 (43%)
		ABC_membrane	976..1248	CDD:279056	85/311 (27%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	121/219 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830