Protein Alignment rdog and mrp-2

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_508121.1
• Gene: mrp-2 / 180408
• WormBaseID: WBGene00003408
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1426
• Identity: 449/1426 - (31%)
• Similarity: 719/1426 - (50%)
• Gaps: 235/1426 - (16%)

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWE---DE------ 69
            |...|:|.::.:|.|...|...|.:..|.:|:|:...:...:|.:...|.:..:   ||
 Worm   208 PEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKPRIDEYHQNIK 272

  Fly    70 ------LKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISEN 128
                  |.:::||.|..|.:.| |..:..|..:.:...:.:.|.|..|..|:|:.......:
 Worm   273 KDPSAALPKNHPSFVIPIFKTY-KYTLLAGFFYKLCFDMLQFLAPQLLKQLIGFIEDKNQPV--- 333

  Fly   129 TAYLYAMGIVICMLVPVITFHPFI-------FY--IFQVGTKLRLALSGLIYRKVLQVSKSSSND 184
                    .:.|.:|.::.|..|:       :|  :|::|..:|..|:..:|.|.|.:|..:...
 Worm   334 --------WIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKG 390

  Fly   185 GLRGRAINILSNDLGRF-DVA---LCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIP 245
            ...|..:|::|.|:.:. |:|   :.|    |..|::..|..:.:::.:|::|:.|:..::..:|
 Worm   391 KTIGAIVNLMSVDIQKIQDMAPTIMLF----WSAPLQIFLSIYFLWKFLGVAALAGLVVLILALP 451

  Fly   246 LQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTA 310
            :....|.:....:....:..|.|:|:|:||:.|::|:|:|:||:|...::.::|.:|:..::..:
 Worm   452 VNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKLS 516

  Fly   311 YIHAALGCTSMISP-LSVFLALCSYVYLGDP----LTAQKVYTVSSYFNMLNDSMVTFWPMSITF 370
            |..||:..:.:.:| |:..::...|||| ||    ||.:..:...|.|::|.        |.:..
 Worm   517 YFMAAIVFSWICAPFLASVISFVVYVYL-DPENNVLTPEITFVALSLFDILR--------MPLAM 572

  Fly   371 IA----EAL---VSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSN 428
            :|    ||:   ||..|.|:|.    .||     |.:.||.                     :|:
 Worm   573 VAMVYGEAVQCSVSNTRLKEFF----AAE-----EMSPQTS---------------------ISH 607

  Fly   429 GQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSS 493
            |:             |...:.::|...||.:.:   :..:.:.|..|:...|.|:||.||:||||
 Worm   608 GE-------------TDSAIEVENGLFSWSSDE---DPTLREISFKIQKGQLVAIVGKVGSGKSS 656

  Fly   494 FLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDME 558
            .|:.||||:....|...::|.|:|..|::|:...::|:||:|.:.|:...|:.|||.|.|:.|:.
 Worm   657 LLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLA 721

  Fly   559 LLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRD--- 620
            .||.||.|.:||:|::||||||.|||||||||:..||.||||||||||:|||||||:..|..
 Worm   722 NLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTG 786

  Fly   621 FLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQE-LQRSRQF-QFLEQTQHDES------ 677
            .|::|.|:||||.:.||...:.|:::..|.|...|:||| |..|..| :|||:...:||
 Worm   787 CLASKTRVLVTHGLTYLKHCDQLIVLKEGTISELGTYQELLNNSGAFAEFLEEFLIEESKTRGRV 851

  Fly   678 ----------------------GI---------------DTHSVSSYLSRSDSEKSM-------E 698
                                  ||               ||.:.:...||..|.:|:       :
 Worm   852 ASIGDGSGEVDEILRDLGQVKPGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQ 916

  Fly   699 HQHNQLL--------RPDEHVEDVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIM 755
            |:.|:.|        ...|:.:.:.:|....|.:|..||.:|.:|:.....|     ||....:.
 Worm   917 HEENEALLGAISEDVPAQENTQLIEKETVETGKVKFEVYIAYFQAISIPITL-----LFFFLYVG 976

  Fly   756 LTGV----DYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIR 816
            .:|:    :::|::  :.:...:.|||                             :||    .:
 Worm   977 SSGLGILSNFYLAK--LSDHAKSGNRT-----------------------------SSD----AK 1006

  Fly   817 QELVLFYATILG-----ATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRI 876
            .||.::  .:||     ..||..:|.|.|    .||.|..||..|...|.|:.|.||:....|||
 Worm  1007 MELGIY--AVLGMGQSFVVLIASIILTIG----VLRASRILHAGLLGNIMRSPMAFFDVTPIGRI 1065

  Fly   877 LNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTS 941
            |||..|||..:|..||..:......|.:|...::::..|..|..|..||:.||..::...|::||
 Worm  1066 LNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYISTS 1130

  Fly   942 RSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALW 1006
            |.:|||||.||||::|...::.||.::|||........::..:..:.:..|::..:...|..|:.
 Worm  1131 RQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPSIVANRWLAVR 1195

  Fly  1007 SDVLCIVYMTAVTFSFLLLKDE--FDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVL 1069
            .:::..:.:.:...:.:..:|.  ..:|.|||::.::..:|....|.:|.|:|||..:.||||:.
 Worm  1196 LEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVERIK 1260

  Fly  1070 EYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRT 1134
            |||..|:|.  ....:...|| ||.||.|...||.:||.|....||..::..|.|.||:||||||
 Worm  1261 EYTVTPTEG--NNSRRLAAKS-WPEKGEISIKNFSVRYRPGLDLVLHGISAHIAPSEKVGIVGRT 1322

  Fly  1135 GAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDER 1198
            ||||||:..::|| :..:.|.|.||.::|.::.|..|||.::|:||||||||||::.||||....
 Worm  1323 GAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAY 1387

  Fly  1199 SDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATAN 1263
            ||.::|:||.:..|:.:|.:|..||..::.:||.|.|||||||:|||||:||..|:|::|||.|.
 Worm  1388 SDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAA 1452

  Fly  1264 VDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGG 1324
            ||.|||.|||:|||.:|..||||||||||:|||||||:||:|.|.|.|...|..||....|
 Worm  1453 VDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPDG 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	448/1423 (31%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	449/1426 (31%)