Protein Alignment rdog and pgp-9

DIOPT Version :9

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_507487.1
• Gene: pgp-9 / 180165
• WormBaseID: WBGene00004003
• Length: 1294
• Species: Caenorhabditis elegans
• Alignment Length: 1489
• Identity: 318/1489 - (21%)
• Similarity: 576/1489 - (38%)
• Gaps: 410/1489 - (27%)

  Fly    45 ELYQHRKTLDSERVTNKFAELWEDELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPL 109
            :||::..|:|                                ::.:.:|:..|.:..:...||.:
 Worm    33 QLYRYTSTVD--------------------------------RLMLAVGIIVSCATGVGLPLMSI 65

  Fly   110 FLGGLVGYFAT--------NQTDISENTA---------------YLY------AMG-------IV 138
            .:|.:...|.|        |.| .||..|               |:|      |.|       :|
 Worm    66 IMGNVSQNFVTLGTIFLDPNST-ASEKAAARAEFSHEVIQNCLKYVYLGCGIFAAGFLQASCFMV 129

  Fly   139 ICMLVPVITFHPFIFYIFQVGTKLRLA-----LSGLIYRKV---LQVSKSSSNDGLRGRAINILS 195
            ||..:.    :.|....|....:..:|     .||.:..|:   |:..:..:.|.: |.|..:::
 Worm   130 ICEKLS----NRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGDKV-GLAFQMMA 189

  Fly   196 NDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQM 260
            ..:|.|.||  |.:| |       |:..:|........:.|    |....|.|.||.|
 Worm   190 QFIGGFAVA--FTYD-W-------LLTLIMMSLSPFMMICG----LFLAKLLATAATK------- 233

  Fly   261 TAERTDMRVKLMNEIIQGIQ-VIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP 324
            .|::..:...:..|::..|: ||.....|....|....:...:...|:.:..|.|.|....:|..
 Worm   234 EAKQYAVAGGIAEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIY 298

  Fly   325 LSVFLAL---CSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWP-MSITFIAEALVSAKRCKDFL 385
            .|..||.   .::||.| .|.:..|.||  :|:::..||..... .....|..||.:|....: :
 Worm   299 ASYCLAFWVGTNFVYSG-RLESGTVLTV--FFSVMMGSMALGQAGQQFATIGTALGAAASLYE-V 359

  Fly   386 LDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVL 450
            :|    .:| .::|....|:...|||.:.....||..                |...|..|  :|
 Worm   360 ID----RIP-EIDAYSTEGQTPSKISGRISVNKVEFT----------------YPTRADVK--IL 401

  Fly   451 KNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHG-- 513
            |.||.  |...|               ||: |:||..|.|||:.:.:|......|.|:.::..
 Worm   402 KGVSL--DAQPG---------------QTV-ALVGSSGCGKSTIIQLLQRFYNPDAGQILIDDIP 448

  Fly   514 ----KISY-------ASQESWVFEGTIRDNIVF-VEDYNERRYKKVVKVCGLERDMELLPRGDLT 566
                .|.|       .|||..:|..:|..||.: ..|.::....:.:|.......::..|.|..|
 Worm   449 IEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEANAADFIKTFPEGLNT 513

  Fly   567 VVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVT 631
            :||:|||.:|||||.|:::|||:.|...|.|||:..||:|.. .:.|....:.:....:..|::.
 Worm   514 LVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAE-SESIVQSALENASRGRTTIVIA 577

  Fly   632 HQVQYLFDVEHLLLMGSGKIM----------AQGSYQELQRSRQFQFLEQTQHDESGIDTHSVSS 686
            |::..:.:.:.:::|.:|::|          .:|.|.||..::.|..::.....:      ....
 Worm   578 HRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDKPKKK------EAER 636

  Fly   687 YLSRSDSE-------KSMEHQHNQLLRP---------DEHVEDVNQEQQTVGSIKMHVYASYIKA 735
            .:||..|:       |:.|.|.::  :|         ::.::.:.:|.:..|::|
 Worm   637 RMSRQTSQRKGSVNFKTQESQVDE--KPGAPPAPEAAEKEIKRLKKELEEEGAVK---------- 689

  Fly   736 LDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATD 800
                      .:||...|       |....|:
 Worm   690 ----------ANLFKILR-------YARPEWI--------------------------------- 704

  Fly   801 PYI-APLLASDIQAGIRQELVLFYATILG-----------------ATLIVYLIRTFG---FFKM 844
             || ..::|:.||..:.....||::.|:.                 |.:.:.|....|   .|:.
 Worm   705 -YIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDRDQMKKDGHFWALMFLVLAAVQGTSMLFQC 768

  Fly   845 CL------RISLHLHDRLFRGITRASMYFFN--TNSSGRILNRFSKDIRTVDTDLPHTLLDCLAF 901
            .|      |:::.:..:::|.:.|....:|:  .:|.|||..|.:.|...:.:.:.:.|......
 Worm   769 SLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAIDYRLGSIFNA 833

  Fly   902 IIDVSGVVIIVAIANYW---------LLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFS 957
            |..|.|.   :.||.|:         .:.|...:|..| |::|...:.:...|.:|:..::.:.:
 Worm   834 IASVGGG---LGIAFYYGWQMAFLVMAIFPFMAVGQAL-MMKYHGGSATSDAKEMENAGKTAMEA 894

  Fly   958 LTNQTFQGLTTIRALQAQSALEQEF-------H------------EYQNTNTSAWFLFLSCTRAF 1003
            :.|     :.|::||..|:.|...|       |            .|...|:..:|.:.:..| |
 Worm   895 IEN-----IRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYGFANSIQFFTYAAAFR-F 953

  Fly  1004 ALW-----------SDVLCIVYMTAVTFSFLLLKDEFDSGDVGLA------ILHSTTMTGMCQWG 1051
            .|:           .:||.:::  |::|||         |.:|.|      .:.:|...|:. :.
 Worm   954 GLFLIFDKNVLMEPENVLRVLF--AISFSF---------GTIGFAASYFPEYIKATFAAGLI-FN 1006

  Fly  1052 MRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPS-KGRIEFINFKLRYSPKEA-PV 1114
            |.:.....:.|||                        ...:|. .|.::......||..:.| |:
 Worm  1007 MLEEEPRIDGMTS------------------------SGTYPQLSGEVKLNKVFFRYPERPAVPI 1047

  Fly  1115 LKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACN-EGMIRIDDVDIEHIGLHDLRSQVSIIP 1178
            |:.||..::|.:.:.:||.:|.|||::|..:.||... ||.:.:|:.|:..:....||..::::.
 Worm  1048 LQGLNVHVKPGQTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVS 1112

  Fly  1179 QDPVLFSGTLR----YNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQR 1239
            |:|:||..::|    |.|.| .|.:.|::..|.....:..::..|..|...|:.:.|:..|.||:
 Worm  1113 QEPILFDTSIRENIVYGLQP-GEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQK 1176

  Fly  1240 QLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVM 1304
            |.:.:|||::|:.|||::||||:.:|.|::|.:|..:.:.....|.:.:||||.|::::..::|:
 Worm  1177 QRIAIARALIRNPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVV 1241

  Fly  1305 DAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAAEQSYS------KQILGDD 1357
            ..|:|.|.|...||:.:.|.|             |||.|....:.|      .:.|.||
 Worm  1242 KNGQVVEQGTHNELIAKRGAY-------------FALTQKQSSNQSGGAFDTSEALDDD 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	313/1467 (21%)
		ABC_membrane	94..360	CDD:294371	67/313 (21%)
		ABCC_MRP_domain1	448..650	CDD:213217	58/215 (27%)
		ABC_membrane	821..1046	CDD:294371	56/297 (19%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	69/224 (31%)
pgp-9	NP_507487.1	PTZ00265	28..1262	CDD:240339	309/1449 (21%)
		ABC_membrane	50..334	CDD:279056	67/313 (21%)
		ABC_MTABC3_MDL1_MDL2	383..620	CDD:213216	69/273 (25%)
		ABC_membrane	710..977	CDD:279056	51/278 (18%)
		ABC_MTABC3_MDL1_MDL2	1030..1269	CDD:213216	76/252 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000