DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and cft-1

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_504463.1	Gene:	cft-1 / 178939	WormBaseID:	WBGene00000477	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	1367	Identity:	320/1367 - (23%)
Similarity:	596/1367 - (43%)	Gaps:	190/1367 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPS 76
            :|...|::|.|:.....:..|.::.....:|.::|....:...|.||.:.|.  |:   ||
Worm    21 ENEQAKSSFASKLLELPVSKLLQKCRSSTITVDDLPILEEKQCSNRVMSGFK--WK---KR---- 76

  Fly    77 VVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICM 141
            |:..||..:.|.|.. ..||.:..........|.|..|:        |.:|.:|.|:...|:..:
Worm    77 VIFSILMKFWKSFAG-AFAFRMCAIFADYASILLLKYLI--------DSAEISATLFNFFIIAVL 132

  Fly   142 LVPVITFHPFIF--YIFQVG---TKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRF 201
            ::..:.....:.  :.:.||   .::...|:.:|.:|.|.:: |.:.|..|.:...:|:......
Worm   133 ILFFMQLKSLLLGVHTYLVGEDSVEMVTVLNNIIVKKALHLT-SENTDWNRSKISKLLTTHSEAV 196

  Fly   202 DVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFM----LSFIPLQAWAAKKAAYYRQMTA 262
            ...|.::|.:....:|..:..|.::..:|...:|.|..:    ..|..:.::..||:.   ::..
Worm   197 SNGLAYVHHSCSALIELTIALFWIWETLGTRTIIVVLIVALVYAVFNIIDSYVYKKSL---KVQL 258

  Fly   263 ERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSV 327
            :..|.||:....::..::.|||::||..|.:.:..:|.||:...|.|..|::.:...::.||..:
Worm   259 KCRDERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVFRKTLSINSFMHSLNVTSPFVI 323

  Fly   328 -FLALCSY--VYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGD 389
             |::...|  .|....|..:..:.:.:.||.:...:....| |:..:.:||.||.....||:
Worm   324 TFVSFAVYGLQYEISALRFEDAFVLIAIFNYMRRPLHVIIP-SLEIVDKALHSATIINQFLI--- 384

  Fly   390 KAEVPINLEANQQTGKNKRKISKKD-KQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNV 453
                          .|...||:.|. .|..||                .|.|       :.:.|.
Worm   385 --------------VKQSPKINTKTAPQPPVE----------------PDLD-------IKILNA 412

  Fly   454 SASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYA 518
            :.||:..|...|    |....:|.....|.:|....||||.|..:.||:.:.||...|...||:|
Worm   413 NFSWNGKDDTLN----DVCVHVKKGEKHAFIGFPLCGKSSLLFSITGELKMTKGNMWVSKGISFA 473

  Fly   519 SQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARV 583
            ....::|..::::||:|..||.:.:|.||:..|.|::|:..|||.:.||:|::|..|:..|||::
Worm   474 PASPYIFSQSLKENILFGNDYVKSKYDKVIMACDLKKDIFSLPRCEATVLGDKGYVLTSTQKAQI 538

  Fly   584 SLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRD--FLSNKIRILVTHQVQYL--FDVEHLL 644
            ||||.:|..||||.||.....:|......||.|.:.:  :|.:|..||.|:.::.:  |.:.|:|
Worm   539 SLARCLYEDADIYALDKAFGPMDRTTSNKIFTRVLGENGYLRDKTVILATNNIELIKTFTMVHVL 603

  Fly   645 LMGSGKIMAQGSYQELQRSRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRP-- 707
              .:|||...|||.        |.||.::         .:|..|::|..:|.:|.:::....|
Worm   604 --KNGKIETSGSYD--------QILECSE---------IMSDLLNQSRIDKIIEEKYSDEKPPRK 649

  Fly   708 ----DEHVEDVNQEQQTVGSI-----KMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFL 763
                |:.|....:::|::...     ...||..|.:: .|.......|.|.:|..:......::|
Worm   650 TVMFDDKVLKKRKKKQSMEDTAPVFENRSVYPFYFRS-GSFIFTAFYIVLLICRFVFQALAFFWL 713

  Fly   764 SRWV--IWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATI 826
            |.|:  :|::                 :..:..|                |....|.:..|..:.
Worm   714 SFWLDPVWKK-----------------VECENCP----------------QYVFIQTMSFFAISA 745

  Fly   827 LGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDL 891
            :.:|::.|   || |....::.|..|:..:...|....|.|.:..:...::|..:.|:..|||..
Worm   746 IISTMLSY---TF-FVLTNVQTSRKLYQHITSAIFAVPMIFLSPTNKESLMNMITSDLDIVDTQF 806

  Fly   892 P---HTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRS 953
            |   ....:|...|:.:..:| .|.:..:.:.:.|.:| .::|::|| ::.....:..||...|.
Worm   807 PLFFKFSFECTLHILMIFAIV-CVNVPVFAIFVVAFLI-FLVGLLRY-FLPALHKISSLEEQKRD 868

  Fly   954 PVFSLTNQTFQGLTTIRAL-QAQSALEQEFHEYQNTNTSAWFLF------LSCTRAFALWSD--- 1008
            .....:.:.|:....:|.. :.:..|.:       |:.:|..|.      .|..|..:|.::
Worm   869 LFLCGSIEDFEARIMVRTFGKTRQTLAK-------TSVNADILTRCRMARYSTLRWISLRTEFIS 926

  Fly  1009 --VLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEY 1071
              ::|:.:..|   |..|..|...:....|::.....::.:....:|.|..||:....|:|:...
Worm   927 NLMICMCFFIA---SICLKVDYIGNAQFALSVASILCISELVSTFIRTTCILESLTPHVQRISNV 988

  Fly  1072 TEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGA 1136
            .|.|.|.::   :|...:..||..|:||..|..: ::.|...|:||::..||.|||:||:|:.|:
Worm   989 REYPKEPMI---DKCTIRDSWPDDGKIEIKNLNV-FANKYRHVIKDVSLVIEEREKLGIIGKVGS 1049

  Fly  1137 GKSSIIQSIFRL--ACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERS 1199
            |||.:.:::..:  |..|..|.:||:||..:.:..|||::::|||...:||.|||.|:||..:.:
Worm  1050 GKSQLAKTLVMMSSADKESHIVVDDLDIFEMSVKTLRSRITVIPQKAKIFSDTLRSNIDPCCQFA 1114

  Fly  1200 DEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANV 1264
            |.::|.|:...:||.||.:|..||:..:  .....|..|:..|.:.||:|:..:|.::|::|..:
Worm  1115 DSDIWLAIEACQLREYVKSLPDGLHQMV--SPEKMSNEQKCQVNVCRALLKGGQIFVIDQSTKMM 1177

  Fly  1265 DPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQL 1329
            ......|:.:.||:.....|.:.|......|...|||:|::.|.:.....|..|:...|...:.|
Worm  1178 KEPIKSLVNEAIRNSLKQSTTIWIGEDFSDVEHCDRVVVIENGVILTTDTPQNLISEFGSLQKCL 1242

  Fly  1330 VD 1331
            ::
Worm  1243 LN 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	320/1367 (23%)
		ABC_membrane	94..360	CDD:294371	53/277 (19%)
		ABCC_MRP_domain1	448..650	CDD:213217	68/205 (33%)
		ABC_membrane	821..1046	CDD:294371	44/239 (18%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	71/220 (32%)
cft-1	NP_504463.1	MdlB	76..631	CDD:224055	155/635 (24%)
		ABC_membrane	93..359	CDD:294371	53/277 (19%)
		P-loop_NTPase	407..607	CDD:304359	68/205 (33%)
		ABC_membrane	696..938	CDD:294371	50/291 (17%)
		P-loop_NTPase	1010..1228	CDD:304359	71/220 (32%)
		EcfA2	1012..1234	CDD:224047	72/224 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850