DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcc2

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_038834.2	Gene:	Abcc2 / 12780	MGIID:	1352447	Length:	1543	Species:	Mus musculus

Alignment Length:	1424	Identity:	456/1424 - (32%)
Similarity:	722/1424 - (50%)	Gaps:	202/1424 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRSNPSVV 78
            |...|:|.|..:|.|......:|.:.|||.|:::...:.|.::.:|:||..:...:|:::..::.
Mouse   193 PSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQ 257

  Fly    79 R------------------------------------------------MILRAYGKIF---VPM 92
            |                                                .:::|..|.|   :..
Mouse   258 RRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILK 322

  Fly    93 GLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQ 157
            .....::..|...|.|..|..|:|:  ....|......|:||:.:....|:.......:..:.|.
Mouse   323 SFILKLAHDILLFLNPQLLKFLIGF--VKDPDSYPWVGYIYAILMFSVTLIQSFFLQCYFQFCFV 385

  Fly   158 VGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIG 222
            :|..:|..:...:|:|.|.:|..:......|..:|::|.|..:......::|..|...::..|..
Mouse   386 LGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSI 450

  Fly   223 FLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAW 287
            |.::||:|.|.:.||..|:..:|:....|.|....:....:..|.|:|:||||:.||:::|.:||
Mouse   451 FFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAW 515

  Fly   288 EKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLALCSYVYLGDP---LTAQKVYTV 349
            |.||...:..:|.||::.:...:.:...|.....::|..|.:...|...|.|.   |.|:|.:|.
Mouse   516 EPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKAFTS 580

  Fly   350 SSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKD 414
            .:.||:|...:... ||.|:.:.:|.||..|.:.:|...|     ::|.|
Mouse   581 ITLFNILRFPLAML-PMVISSVIQASVSVDRLEQYLGSDD-----LDLSA--------------- 624

  Fly   415 KQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQT 479
                            :.|  :..:|     |.|.....|.:||..   ....|:|.:.|||...
Mouse   625 ----------------IRH--VCHFD-----KAVQFSEASFTWDRD---LEATIQDVNLDIKPGQ 663

  Fly   480 LAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRY 544
            |.||||.||:||||.::.:|||:....|...:.|.|:|..|::|:..|||:|||:|..:|:|::|
Mouse   664 LVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKY 728

  Fly   545 KKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHV 609
            ::|::.|.|..|:|:||.||:..:||:|::||||||.|||||||.|:.||||:||||||||||||
Mouse   729 QRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHV 793

  Fly   610 GKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSRQF------ 666
            |||||::.:  ...||.|.||||||.:.:|..|:.::::|.|.|:.:|||.:|...:..
Mouse   794 GKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWK 858

  Fly   667 QFLEQT-----------QHDESG----IDT----------------HSVSSYLSRSDSEKSMEHQ 700
            .|::.:           ..:|.|    |.|                :|:...||||....|...:
Mouse   859 TFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGK 923

  Fly   701 H----------NQLLRPDEHVED---VNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCA 752
            .          |.|.:.:|.|:.   :.:|....|.:|..:|..|::|:....||.||| .:|..
Mouse   924 SLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSLLFIVI-FYVLN 987

  Fly   753 RIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQ 817
            .:...|.:.:||.|....|:         .|.||.:.:...:.|....           ..||.|
Mouse   988 YVAFIGTNLWLSAWTSDSEK---------QNGTDNSPSQRDMRIGVFG-----------ALGIAQ 1032

  Fly   818 ELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSK 882
            .:.|..:::..    :|         .|...|..||.:|...|.||.|.||:|..:|||:|||:.
Mouse  1033 GIFLLSSSLWS----IY---------ACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAG 1084

  Fly   883 DIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIAN---YWLLIPAAIIGVILGMIRYLYVNTSRSV 944
            ||.|||..||.||...|.....:...::::.:|.   ..::||.:|:.|   .::..||.|||.:
Mouse  1085 DISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYV---SVQVFYVATSRQL 1146

  Fly   945 KRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV 1009
            :||:|:::||::|..::|..||..|||.:.|........:..:||....|.:::..|..|:..::
Mouse  1147 RRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLEL 1211

  Fly  1010 L--CIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYT 1072
            :  .||:.:|:.  .::.|:......||..:.::..:|....|.:|.|:|:|..:.:|||:.||.
Mouse  1212 VGNLIVFCSALL--LVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYI 1274

  Fly  1073 EQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAG 1137
            ...:||...|.:  ||.::||.||.|:|.|:::||.|:...|||.:...|:..||:|:|||||||
Mouse  1275 NVDNEAPWVTDK--KPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAG 1337

  Fly  1138 KSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDE 1201
            |||:...:|| |....|.|.||.:||..|||||||.:::||||||:||||.||.||||.::.|||
Mouse  1338 KSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDE 1402

  Fly  1202 EMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDP 1266
            |:|:||....|:|:|:.|..||...:.:||.|.|:|||||:||.||:||.:|||::|||||.||.
Mouse  1403 EIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDL 1467

  Fly  1267 ETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGY 1325
            |||.|||.|||::|:.|||:||||||||:||||:::|:|:|::.|.|.|.|||...|.:
Mouse  1468 ETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSNMGPF 1526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	456/1424 (32%)
		ABC_membrane	94..360	CDD:294371	67/268 (25%)
		ABCC_MRP_domain1	448..650	CDD:213217	98/203 (48%)
		ABC_membrane	821..1046	CDD:294371	64/229 (28%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	124/219 (57%)
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	456/1424 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..285		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..927		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830