DRSC/TRiP Functional Genomics Resources

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Protein Alignment rdog and Cftr

DIOPT Version :10

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_312930.5 Gene:Cftr / 1273896 VectorBaseID:AGAMI1_011650 Length:1450 Species:Anopheles gambiae


Alignment Length:1498 Identity:559/1498 - (37%)
Similarity:810/1498 - (54%) Gaps:238/1498 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRS--- 73
            |||...|...||..|.|:..||.||.:..|..::|.:..|...||.:.::..|.||.|:.::   
Mosquito    10 KNPRKGAFCLSQLFFGWLLPLFYRGSRRGLGKDDLTKCLKADRSEDLGDELEEQWEKEVSQARIA 74

  Fly    74 --NPSVVRMILRAYGK----------IFV------PMGLA---------------------FSIS 99
              .|.:...:.|.:.|          :||      |:.||                     ..:.
Mosquito    75 SREPKLRNALFRTFYKQSLFDGFLIFLFVLIKTILPVVLAQLLVQFQEPTNSTHVAVVNMNNDVF 139

  Fly   100 ETICKSLMPLFL--------------------------------------GGLVGYFATNQT--- 123
            .|:....|||.:                                      |..:|....|..   
Mosquito   140 STVPPMAMPLMMLPDTTQSHLENLVFDETAMINKRRRKRRIRIEDDKPAPGNSIGGSKPNVAQEA 204

  Fly   124 ---------DISE---------------------------NTAYLYAMGIVICMLVPVITFHPFI 152
                     |:||                           |.|:..:..:|:..|:.....|...
Mosquito   205 EAMETTILPDLSEQFGADDPSATANSTVVDDLSDFLHHAWNDAFWLSGLLVLLTLLGCFCCHHSD 269

  Fly   153 FYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPME 217
            .....||.::|:|...|||||.|::|:.::.....|..||:||||:.|.|....::|..|..|.:
Mosquito   270 LRERLVGARMRIACCSLIYRKTLRMSRKAAGQTPAGYMINLLSNDVSRLDYGFIYVHYVWVLPFQ 334

  Fly   218 SILIGFLMYREIGISAVIG-VSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQV 281
            :....:|::|.:..:|::| |..::..||:|...::.::..|...|::||.||.:|||:||||||
Mosquito   335 ACFTCYLIWRRVQWAAIVGVVGLLVKTIPVQTGLSRLSSIIRMRVAKKTDQRVGIMNELIQGIQV 399

  Fly   282 IKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLS-VFLALCSYVYLGDPLTAQK 345
            ||||||||.|.:|::..|.|||:.||..:||......|.:.:..| :|||:...|..|..:||..
Mosquito   400 IKMYAWEKPFHKVVSLARKKEVRQIRWASYIRGIYLSTMVFTERSTLFLAIACCVIEGRAITADI 464

  Fly   346 VYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKI 410
            |:.::.:||:|..:...|:|::::..||||||..|.::||...:....|.:..|   ||..||.:
Mosquito   465 VFPMAQFFNILQLTAAIFYPLAVSLGAEALVSIDRIQEFLALQEHDATPPSASA---TGGLKRNL 526

  Fly   411 SKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASW-DTSDGHANCAIEDFSTD 474
            :                  .:|  .|.::|   .|..:.|:||:||| :|:|.    .::|.|..
Mosquito   527 N------------------DLH--LLAEHD---NKPAIELQNVTASWEETTDK----TLKDISVK 564

  Fly   475 IKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDY 539
            |:...|.||:|||||||||.|.:||||:.|..|.|.::|.:||.|||.|:|.||:|:||:|...|
Mosquito   565 IEPGRLLAVIGPVGAGKSSLLQMLLGELPIQNGTATINGDVSYGSQEPWLFTGTVRNNILFGLPY 629

  Fly   540 NERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSA 604
            :..||:.||:.|.|..|.:.||.||.|||||||.||||||:||||||||||..|.||||||||||
Mosquito   630 DRHRYQAVVRHCALTTDFQQLPDGDKTVVGERGTSLSGGQRARVSLARAVYNNASIYLLDDPLSA 694

  Fly   605 VDTHVGKHIFDRCI--RDFLSNK---IRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSR 664
            ||.|||||:||..|  |.:|:.|   .|:||||||.:|.:.:.::::..|||:.||:|.||...:
Mosquito   695 VDAHVGKHLFDEVIGPRGYLAQKQKATRVLVTHQVHFLKEADWIVIIEGGKIVTQGTYTELANGK 759

  Fly   665 -QFQFLEQTQHDESG------------------IDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEH 710
             .|..|.::...|.|                  ||..::..|.....|..|:..     :.|...
Mosquito   760 VDFGKLLKSGEPEKGGADDSVLAADIPEDEIPFIDGVTLDGYKLLKGSTVSLRG-----VTPSSC 819

  Fly   711 VEDVNQ-------EQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVI 768
            ...|..       |.|..|:|...::|:|..:..:..:|.....:.:.::.:::|.|||::.|..
Mosquito   820 ASSVADNLGRQVAEDQAEGTISWRIWATYFLSGGNVLMLLFTFLMLLFSQAIVSGSDYFVTYWTR 884

  Fly   769 WEEQIAVNR---TTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGAT 830
            .||...||.   |||                                   :.:.:..|..|:...
Mosquito   885 QEELRLVNERAVTTT-----------------------------------KVDFLYTYGVIIIGV 914

  Fly   831 LIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTL 895
            ::..:.|.:.||.:|::.|.:||||:|..:..|.|.||:||.|||||||||||:..:|..||..:
Mosquito   915 VVFTIFRGYLFFNICMKASRNLHDRMFARMLTAPMRFFDTNPSGRILNRFSKDMGAIDELLPKAM 979

  Fly   896 LDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVIL--GMIRYLYVNTSRSVKRLESISRSPVFSL 958
            ::.:..::.::|::.::.|.|..||:|  ::|.:|  .:...||:...:.:||||.|:||||||.
Mosquito   980 IEAIQILLVMTGILTMITIVNPLLLLP--LLGAVLLYAIALKLYLRPIQDMKRLEGITRSPVFSH 1042

  Fly   959 TNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFL 1023
            .:.|..||:||||...|..:.:||.:.||.:::.|.|.:|...|..||.|.:...::..|||||:
Mosquito  1043 LSATLSGLSTIRASGVQEKIREEFDDLQNVHSAVWQLTMSSNAALGLWLDCISTAFVACVTFSFI 1107

  Fly  1024 LLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKP 1088
            :|..:..|.:|||||..:..:|||.|:|:|||.|...|||:||||::|||..||.   .|.|. |
Mosquito  1108 VLHQDTYSANVGLAISQALILTGMVQYGIRQTTESIQQMTAVERVVQYTEIASET---DPPKV-P 1168

  Fly  1089 KSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNEG 1153
            ..:||.||:|:|.|..|.|.....||||:|...|||..|:||||||||||||:|.::||||..||
Mosquito  1169 PGDWPWKGQIQFHNMSLCYEQDAPPVLKNLELVIEPTWKVGIVGRTGAGKSSLIGALFRLARIEG 1233

  Fly  1154 MIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVST 1218
            .|.||.:|...|.|..|||::|||||||||||.|:||||||.....|:.:|:|:|:|||||.:| 
Mosquito  1234 RIMIDGIDTGVISLEALRSKISIIPQDPVLFSATIRYNLDPFSLYDDDMLWRAIGEVELRSAIS- 1297

  Fly  1219 LIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHC 1283
               ||:..:.:||:|||||||||:||||||||:||||::|||||||||:||.|||:|||.||.||
Mosquito  1298 ---GLDFMVTEGGTNFSVGQRQLICLARAILRNNKILVLDEATANVDPQTDALIQKTIREKFKHC 1359

  Fly  1284 TVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAAEQS 1348
            ||||:||||||||||||:|||||||.||...|:.|||:.||.|:.:|:.||.:.|.:|::.|.::
Mosquito  1360 TVLTVAHRLHTVMDSDRILVMDAGEAREFDTPHILLQQEGGILKDMVEATGPSESESLKRIAAET 1424

  Fly  1349 YSK 1351
            |::
Mosquito  1425 YAQ 1427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 MRP_assoc_pro 14..1323 CDD:188098 547/1466 (37%)
CftrXP_312930.5 MRP_assoc_pro <276..1404 CDD:188098 507/1207 (42%)

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