Protein Alignment rdog and Cftr

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_066388.1
• Gene: Cftr / 12638
• MGIID: 88388
• Length: 1476
• Species: Mus musculus
• Alignment Length: 1502
• Identity: 394/1502 - (26%)
• Similarity: 687/1502 - (45%)
• Gaps: 273/1502 - (18%)

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWE-DELKRSNP 75
            |:|..||:|.|:..|.|...:.::|.:..|...::||......::.::.|....|: ::..:.||
Mouse     3 KSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDREQASKKNP 67

  Fly    76 SVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLV-GYFATNQTDISENTAYLYAMGIVI 139
            .::..:.|.:...|:..|:...:.| :.|::.|:.||.:: .|...|:.   |.:..:| :||.:
Mouse    68 QLIHALRRCFFWRFLFYGILLYLGE-VTKAVQPVLLGRIIASYDPENKV---ERSIAIY-LGIGL 127

  Fly   140 CML--VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFD 202
            |:|  |..:..||.||.:.::|.::|.|:..|||:|.|::|....:....|:.:::|||:|.:||
Mouse   128 CLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFD 192

  Fly   203 VALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDM 267
            ..|...|..|..|::..|:..|::..:..||..|:..::..:..||...|....||...|.:.:.
Mouse   193 EGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAKINE 257

  Fly   268 RVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLAL 331
            |:.:.:|||..|..:|.|.||.:..::|..:|..|:|..|..||:..........|. ..|||::
Mouse   258 RLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGFFVVFLSV 322

  Fly   332 CSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPIN 396
            ..|..: :.:..:|::|..|:..:|..|:...:|.::....::....::.:|||
Mouse   323 LPYTVI-NGIVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSFGMIRKIQDFL----------- 375

  Fly   397 LEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSD 461
                           :|.:.|.:|.|  |::.|                  ::::||:|.|:...
Mouse   376 ---------------QKQEYKVLEYN--LMTTG------------------IIMENVTAFWEEGF 405

  Fly   462 GH-----------------------------ANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNV 497
            |.                             .|..:::.:.:|:...:.|:.|..|:||:|.|.:
Mouse   406 GELLEKVQQSNGDRKHSSDENNVSFSHLCLVGNPVLKNINLNIEKGEMLAITGSTGSGKTSLLML 470

  Fly   498 LLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPR 562
            :|||:...:|.....|::|:.||.||:..|||::||:|...|:|.|||.|||.|.|::|:.....
Mouse   471 ILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAE 535

  Fly   563 GDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIR 627
            .|.||:||.||:|||||:||:|||||||:.||:||||.|...:|....:.:|:.|:...::||.|
Mouse   536 QDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTR 600

  Fly   628 ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSR-QFQ--------FLEQTQHDESGIDTHS 683
            ||||.::::|...:.:|::..|.....|::.|||..| .|.        |.:.|:...|.|.|.:
Mouse   601 ILVTSKMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTET 665

  Fly   684 VSSYLSRSDSEKSM--------------EHQHNQLLRPDEHVEDVNQEQQT-------------- 720
            :..: |..||....              |.:.|.:|.....|..::..|:|
Mouse   666 LRRF-SVDDSSAPWSKPKQSFRQTGEVGEKRKNSILNSFSSVRKISIVQKTPLCIDGESDDLQEK 729

  Fly   721 --------------------------------------------------------------VGS 723
                                                                          |..
Mouse   730 RLSLVPDSEQGEAALPRSNMIATGPTFPGRRRQSVLDLMTFTPNSGSSNLQRTRTSIRKISLVPQ 794

  Fly   724 IKMHVYASYIKAL--DST-----------------------------------FLL--GIVISLF 749
            |.::....|.:.|  |||                                   |.|  |:::.|.
Mouse   795 ISLNEVDVYSRRLSQDSTLNITEEINEEDLKECFLDDVIKIPPVTTWNTYLRYFTLHKGLLLVLI 859

  Fly   750 VCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAG 814
            .|..:.|  |:...|.:|:|           ||........|:...| :...|:..:.::..
Mouse   860 WCVLVFL--VEVAASLFVLW-----------LLKNNPVNSGNNGTKI-SNSSYVVIITSTSF--- 907

  Fly   815 IRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNR 879
              ..:...|..:....|.:.|.|........:..|..||.::...|..|.|...:...:|.||||
Mouse   908 --YYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTISKLKAGGILNR 970

  Fly   880 FSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIV-AIANYWLL--IPAAIIGVILGMIRYLYVNTS 941
            |||||..:|..||.|:.|.:..:..|.|.:|:| |:..|..|  :|..::.::|   |..:::|:
Mouse   971 FSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYIFLATVPGLVVFILL---RAYFLHTA 1032

  Fly   942 RSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALW 1006
            :.:|:|||..|||:|:....:.:||.|:||.:.|:..|..||:..|.:|:.||::|:..|.|.:.
Mouse  1033 QQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMR 1097

  Fly  1007 SDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLE- 1070
            .|::.:::...|||..:|...| ..|..|:.:..:..:....||.:..:.:.::.|.||.||.:
Mouse  1098 IDMIFVLFFIVVTFISILTTGE-GEGTAGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKF 1161

  Fly  1071 ---------YT--------EQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDL 1118
                     ||        |..|:.|:...|..|....|||.|.:...:..::|......||:::
Mouse  1162 IDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIWPSGGEMVVKDLTVKYMDDGNAVLENI 1226

  Fly  1119 NFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVL 1183
            :|:|.|.:::|::||||:|||:::.:..|:...:|.|.||.|....:.|.:.|....:|.|...:
Mouse  1227 SFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGDIEIDGVSWNSVTLQEWRKAFGVITQKVFI 1291

  Fly  1184 FSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAI 1248
            ||||.|.||||..:..|||:||...:|.|:|.:....|.||..:.|||...|.|.:||:||||::
Mouse  1292 FSGTFRQNLDPNGKWKDEEIWKVADEVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSV 1356

  Fly  1249 LRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELG 1313
            |...||:::||.:|::||.|.::|::.::..||.|||:...||:..::|..|.||::...|.:
Mouse  1357 LSKAKIILLDEPSAHLDPITYQVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLVIEESNVWQ-- 1419

  Fly  1314 HPYELLQ 1320
              |:.||
Mouse  1420 --YDSLQ 1424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	393/1500 (26%)
Cftr	NP_066388.1	CFTR_protein	1..1464	CDD:273530	394/1502 (26%)
		Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569	654..826		20/172 (12%)
		Interaction with GORASP2. /evidence=ECO:0000250|UniProtKB:P13569	1382..1476		15/47 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1446..1476
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569	1474..1476