DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and Abcc5

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_446376.1	Gene:	Abcc5 / 116721	RGDID:	70913	Length:	1436	Species:	Rattus norvegicus

Alignment Length:	1413	Identity:	471/1413 - (33%)
Similarity:	739/1413 - (52%)	Gaps:	147/1413 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKVVRPKNPFTKANFFSQWSFWWMRDL----FKRGLQGPLTDEELYQHRKTLDSERVTNKFAELW 66
            |...:.::|...|..||..:|.|:..|    .|:   |.|..|:::...|...|:....:...||
  Rat    92 RTTTKHQHPVDNAGLFSYMTFSWLSPLAQVVHKK---GELLMEDVWPLSKYESSDVNCRRLERLW 153

  Fly    67 EDELKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVG----------YFATN 121
            ::||....|....  ||....||....|..||   :|  ||...|.|..|          |  |.
  Rat   154 QEELNEVGPDAAS--LRRVVWIFCRTRLILSI---VC--LMITQLAGFSGPAFVVKHLLEY--TQ 209

  Fly   122 QTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGL 186
            .|:.:...:.|..:|:::..:|...:........::.|.:||.|:..:.::|:|:: |:.....|
  Rat   210 ATESNLQYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAVLTMAFKKILKL-KNIKEKSL 273

  Fly   187 RGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREI--GISAVIGVSFMLSFIPLQAW 249
             |..|||.|||..|...|.........||:.:||  .::|..|  |.:..:|.:..:.|.|...:
  Rat   274 -GELINICSNDGQRMFEAAAVGSLLAGGPVVAIL--GMIYNVIILGPTGFLGSAVFILFYPAMMF 335

  Fly   250 AAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHA 314
            .::..||:|:.....||.||:.|||::..|:.||||||.|:|::.:.::|.:|.:.:....|..:
  Rat   336 VSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQS 400

  Fly   315 ALGCTSMISPLSVFLA----LCSYVYLGDPLTAQKVYTVSSYFNMLNDSM-VTFWPMSITFIAEA 374
               .|..::|:.|.:|    ...::.||..|||.:.:||.:.||.:..:: ||  |.|:..::||
  Rat   401 ---ITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT--PFSVKSLSEA 460

  Fly   375 LVSAKRCKD-FLLD------GDKAEVPINLE---------ANQQTGKNKRKISKKDKQKNVELNG 423
            .|:..|.|. ||::      ...|...|.:|         ::..:.::..|::.|.|:......|
  Rat   461 SVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSPKLTPKVKKDKRAPKG 525

  Fly   424 SLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDG---HANC-----AIEDFSTDIKDQTL 480
            ....:.|:.|...:....|.....::..:...|.:..:|   ||..     .:.:...:|::..|
  Rat   526 KKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHAGSMRLQRTLYNIDLEIEEGKL 590

  Fly   481 AAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYK 545
            ..:.|.||:||:|.::.:||::.:.:|...|.|..:|.:|::|:...|:||||:|.::::|.||.
  Rat   591 VGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFGKEFDEERYN 655

  Fly   546 KVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVG 610
            .|:..|.|..|:.:||..|||.:||||.:|||||:.|:|||||:|....||:|||||||:|.|||
  Rat   656 SVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720

  Fly   611 KHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR-----SRQFQFLE 670
            .|||:..||..|.:|..:.||||:|||.|.:.::.|..|.|..:|:::||..     :..|..|.
  Rat   721 NHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLL 785

  Fly   671 QTQHDESGIDTHSVSSYLSRSD----------SEKSMEHQHNQLLRPDEHVEDVNQEQQTVGSIK 725
            ..:.....|::...:|...:|.          .||:::.:..||::    ||:..|     ||:.
  Rat   786 LGETPPVEINSKKEASGSQKSQDKGPKPGSVKKEKAVKSEEGQLVQ----VEEKGQ-----GSVP 841

  Fly   726 MHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWV-IWEEQIAVNRTTTLLNETDTTI 789
            ..||..||:|........:::.||    ::..|...|.:.|: .|.:|.:.|.|   :.|.:.:.
  Rat   842 WSVYWVYIQAAGGPLAFLVIMVLF----MLNVGSTAFSTWWLSYWIKQGSGNST---VFEGNRSS 899

  Fly   790 ANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHD 854
            .:|::..|....|.|.:                ||..:...||:..||...|.|..||.|..|||
  Rat   900 VSDSMRDNPFLQYYASI----------------YALSMAVMLILKAIRGVVFVKGTLRASSRLHD 948

  Fly   855 RLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWL 919
            .|||.|.|:.|.||:|..:||||||||||:..||..||......:..:|.|...|.::|....|.
  Rat   949 ELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWF 1013

  Fly   920 LI---PAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQE 981
            |:   |..|:..:|.::..:.:   |.:|||::|::||..|....:.|||.||.|...:    ||
  Rat  1014 LVAVGPLLILFSVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKR----QE 1071

  Fly   982 F-HEYQ---NTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEFDSGDVGLAILHST 1042
            | |.||   :.|.:.:|||....|..|:..|::.|..:|......:|:..:..|...||||.::.
  Rat  1072 FLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAV 1136

  Fly  1043 TMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFK---PKSEWPSKGRIEFINFK 1104
            .:||:.|:.:|..:|.|.:.|||||:..|.:..|   ||.|.:.|   |..:||.:|.|.|.|.:
  Rat  1137 QLTGLFQFTVRLASETEARFTSVERINHYIKTLS---LEAPARIKNKAPPHDWPQEGEITFENAE 1198

  Fly  1105 LRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLH 1168
            :||......|||.::|||:|:||||||||||:||||:..::|||. .:.|.|:||.|.|..|||.
  Rat  1199 MRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLA 1263

  Fly  1169 DLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSN 1233
            ||||:::||||:|||||||:|.||||.::.::|::|.||....::..::.|...|...:.:.|.|
  Rat  1264 DLRSKLTIIPQEPVLFSGTVRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDN 1328

  Fly  1234 FSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDS 1298
            ||||:|||:|:|||:|||.||||:|||||.:|.|||.|||:|||..||.||:||||||||||:.|
  Rat  1329 FSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGS 1393

  Fly  1299 DRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAAE 1346
            ||::|:..|:|.|...|..||            :..::..:|:..|||
  Rat  1394 DRIMVLAQGQVVEFDTPSVLL------------SNDSSRFYAMCAAAE 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	467/1402 (33%)
		ABC_membrane	94..360	CDD:294371	77/281 (27%)
		ABCC_MRP_domain1	448..650	CDD:213217	83/209 (40%)
		ABC_membrane	821..1046	CDD:294371	81/231 (35%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	121/219 (55%)
Abcc5	NP_446376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..38
		PLN03130	100..1424	CDD:215595	466/1398 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..569		9/69 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..822		4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660