Protein Alignment rdog and CFTR

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Alignment Length: 1535
• Identity: 414/1535 - (26%)
• Similarity: 725/1535 - (47%)
• Gaps: 248/1535 - (16%)

  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDEL-KRSNP 75
            ::|..||:..|:..|.|.|.:.::|.:..|...::||......::.::.|....|:.|| .:.||
Human     3 RSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNP 67

  Fly    76 SVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVIC 140
            .::..:.|.:...|:..|:...:.| :.|::.||.||.::   |:...|..|..:....:||.:|
Human    68 KLINALRRCFFWRFMFYGIFLYLGE-VTKAVQPLLLGRII---ASYDPDNKEERSIAIYLGIGLC 128

  Fly   141 ML--VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDV 203
            :|  |..:..||.||.:..:|.::|:|:..|||:|.|::|....:....|:.:::|||:|.:||.
Human   129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDE 193

  Fly   204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268
            .|...|..|..|::..|:..|::..:..||..|:.|::.....||...:....||...|.:...|
Human   194 GLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISER 258

  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLALC 332
            :.:.:|:|:.||.:|.|.||::..::|..:|..|:|..|..||:..........|. ..|||::.
Human   259 LVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVL 323

  Fly   333 SYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINL 397
            .|..: ..:..:|::|..|:..:|..::...:|.::....::|.:..:.:|||
Human   324 PYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFL------------ 375

  Fly   398 EANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWD---- 458
                          :|.:.|.:|.|                    .|...||::||:|.|:
Human   376 --------------QKQEYKTLEYN--------------------LTTTEVVMENVTAFWEEGFG 406

  Fly   459 --------------TSDGHANC-----------AIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVL 498
                          ||:|..:.           .::|.:..|:...|.||.|..||||:|.|.|:
Human   407 ELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471

  Fly   499 LGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRG 563
            :||:...:|:....|:||:.||.||:..|||::||:|...|:|.||:.|:|.|.||.|:......
Human   472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536

  Fly   564 DLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRI 628
            |..|:||.|::|||||:||:|||||||:.||:||||.|...:|....|.||:.|:...::||.||
Human   537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRI 601

  Fly   629 LVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR--------------------SRQFQFLEQTQ 673
            |||.::::|...:.:|::..|.....|::.|||.                    .|:...|.:|.
Human   602 LVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETL 666

  Fly   674 HDESGIDTHSVSSYLSRSDSEKSM----EHQHNQLLRP------------------------DEH 710
            |..|......||...::..|.|..    |.:.|.:|.|                        ||.
Human   667 HRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEP 731

  Fly   711 VE-------DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIV--------------------ISL 748
            :|       |..|.:..:..|.:......::|.....:|.::                    :||
Human   732 LERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSL 796

  Fly   749 FVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIA----NDTLP-INATDPYI----- 803
              ..:..||.:|.: ||.:..|..:.::..   :||.|....    .:::| :...:.|:
Human   797 --APQANLTELDIY-SRRLSQETGLEISEE---INEEDLKECFFDDMESIPAVTTWNTYLRYITV 855

  Fly   804 -----------APLLASDIQAGIRQELVLF--------------------YATILGATLIVYL-- 835
                       ..:..:::.|.:   :||:                    ||.|:.:|...|:
Human   856 HKSLIFVLIWCLVIFLAEVAASL---VVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFY 917

  Fly   836 --------IRTFGFFK------MCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRT 886
                    :...|||:      ..:.:|..||.::...:.:|.|...||..:|.|||||||||..
Human   918 IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAI 982

  Fly   887 VDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESIS 951
            :|..||.|:.|.:..::.|.|.:.:||:...::.:....:.|...|:|..::.||:.:|:|||..
Human   983 LDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEG 1047

  Fly   952 RSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMT 1016
            |||:|:....:.:||.|:||...|...|..||:..|.:|:.|||:||..|.|.:..:::.:::..
Human  1048 RSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFI 1112

  Fly  1017 AVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEA--- 1078
            ||||..:|...| ..|.||:.:..:..:....||.:..:.::::.|.||.||.::.:.|:|.
Human  1113 AVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPT 1176

  Fly  1079 ---------------LLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKI 1128
                           ::|. ...|....|||.|::...:...:|:.....:|::::|:|.|.:::
Human  1177 KSTKPYKNGQLSKVMIIEN-SHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRV 1240

  Fly  1129 GIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLD 1193
            |::||||:|||:::.:..||...||.|:||.|..:.|.|...|....:|||...:||||.|.|||
Human  1241 GLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD 1305

  Fly  1194 PMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMD 1258
            |.::.||:|:||...:|.|||.:....|.|:..:.|||...|.|.:||:||||::|...|||::|
Human  1306 PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLD 1370

  Fly  1259 EATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323
            |.:|::||.|.::|::|::..||.|||:...||:..:::..:.||::..:||:.....:||...
Human  1371 EPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNER- 1434

  Fly  1324 GYLRQLVDNTGAATSFALQQAAEQSYSKQI--LGDDTAAE 1361
            ...||.:..:.....|..:.:::.....||  |.::|..|
Human  1435 SLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEE 1474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	406/1491 (27%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	414/1535 (27%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		32/182 (18%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		22/90 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		5/23 (22%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480