Sequence 1: | NP_651678.1 | Gene: | rdog / 43450 | FlyBaseID: | FBgn0039644 | Length: | 1374 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_000483.3 | Gene: | CFTR / 1080 | HGNCID: | 1884 | Length: | 1480 | Species: | Homo sapiens |
Alignment Length: | 1535 | Identity: | 414/1535 - (26%) |
---|---|---|---|
Similarity: | 725/1535 - (47%) | Gaps: | 248/1535 - (16%) |
- Green bases have known domain annotations that are detailed below.
Fly 12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDEL-KRSNP 75
Fly 76 SVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVIC 140
Fly 141 ML--VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDV 203
Fly 204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268
Fly 269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLALC 332
Fly 333 SYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINL 397
Fly 398 EANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWD---- 458
Fly 459 --------------TSDGHANC-----------AIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVL 498
Fly 499 LGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRG 563
Fly 564 DLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRI 628
Fly 629 LVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR--------------------SRQFQFLEQTQ 673
Fly 674 HDESGIDTHSVSSYLSRSDSEKSM----EHQHNQLLRP------------------------DEH 710
Fly 711 VE-------DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIV--------------------ISL 748
Fly 749 FVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIA----NDTLP-INATDPYI----- 803
Fly 804 -----------APLLASDIQAGIRQELVLF--------------------YATILGATLIVYL-- 835
Fly 836 --------IRTFGFFK------MCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRT 886
Fly 887 VDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESIS 951
Fly 952 RSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMT 1016
Fly 1017 AVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEA--- 1078
Fly 1079 ---------------LLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKI 1128
Fly 1129 GIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLD 1193
Fly 1194 PMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMD 1258
Fly 1259 EATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323
Fly 1324 GYLRQLVDNTGAATSFALQQAAEQSYSKQI--LGDDTAAE 1361 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
rdog | NP_651678.1 | CFTR_protein | 12..1343 | CDD:273530 | 409/1513 (27%) |
ABC_membrane | 94..360 | CDD:294371 | 74/268 (28%) | ||
ABCC_MRP_domain1 | 448..650 | CDD:213217 | 88/230 (38%) | ||
ABC_membrane | 821..1046 | CDD:294371 | 75/260 (29%) | ||
ABCC_MRP_domain2 | 1096..1315 | CDD:213211 | 82/218 (38%) | ||
CFTR | NP_000483.3 | CFTR_protein | 1..1480 | CDD:273530 | 414/1535 (27%) |
ABC_membrane | 85..303 | CDD:279056 | 66/221 (30%) | ||
ABCC_CFTR1 | 389..670 | CDD:213258 | 97/280 (35%) | ||
CFTR_R | 639..849 | CDD:291094 | 33/215 (15%) | ||
Disordered R region. /evidence=ECO:0000269|PubMed:10792060 | 654..831 | 32/182 (18%) | |||
ABC_membrane | 866..1147 | CDD:279056 | 79/284 (28%) | ||
ABCC_CFTR2 | 1208..1480 | CDD:213256 | 92/268 (34%) | ||
Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936 | 1386..1480 | 22/90 (24%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1452..1480 | 5/23 (22%) | |||
PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976 | 1478..1480 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C165151598 | |
Domainoid | 1 | 1.000 | 62 | 1.000 | Domainoid score | I10331 |
eggNOG | 1 | 0.900 | - | - | E2759_KOG0054 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D138195at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 1 | 1.100 | - | - | O | PTHR24223 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
7 | 6.850 |