DRSC/TRiP Functional Genomics Resources

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Protein Alignment rdog and CFTR

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_000483.3 Gene:CFTR / 1080 HGNCID:1884 Length:1480 Species:Homo sapiens


Alignment Length:1535 Identity:414/1535 - (26%)
Similarity:725/1535 - (47%) Gaps:248/1535 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDEL-KRSNP 75
            ::|..||:..|:..|.|.|.:.::|.:..|...::||......::.::.|....|:.|| .:.||
Human     3 RSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNP 67

  Fly    76 SVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVIC 140
            .::..:.|.:...|:..|:...:.| :.|::.||.||.::   |:...|..|..:....:||.:|
Human    68 KLINALRRCFFWRFMFYGIFLYLGE-VTKAVQPLLLGRII---ASYDPDNKEERSIAIYLGIGLC 128

  Fly   141 ML--VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDV 203
            :|  |..:..||.||.:..:|.::|:|:..|||:|.|::|....:....|:.:::|||:|.:||.
Human   129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDE 193

  Fly   204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268
            .|...|..|..|::..|:..|::..:..||..|:.|::.....||...:....||...|.:...|
Human   194 GLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISER 258

  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLALC 332
            :.:.:|:|:.||.:|.|.||::..::|..:|..|:|..|..||:..........|. ..|||::.
Human   259 LVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVL 323

  Fly   333 SYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINL 397
            .|..: ..:..:|::|..|:..:|..::...:|.::....::|.:..:.:|||            
Human   324 PYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFL------------ 375

  Fly   398 EANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWD---- 458
                          :|.:.|.:|.|                    .|...||::||:|.|:    
Human   376 --------------QKQEYKTLEYN--------------------LTTTEVVMENVTAFWEEGFG 406

  Fly   459 --------------TSDGHANC-----------AIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVL 498
                          ||:|..:.           .::|.:..|:...|.||.|..||||:|.|.|:
Human   407 ELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471

  Fly   499 LGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRG 563
            :||:...:|:....|:||:.||.||:..|||::||:|...|:|.||:.|:|.|.||.|:......
Human   472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536

  Fly   564 DLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRI 628
            |..|:||.|::|||||:||:|||||||:.||:||||.|...:|....|.||:.|:...::||.||
Human   537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRI 601

  Fly   629 LVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR--------------------SRQFQFLEQTQ 673
            |||.::::|...:.:|::..|.....|::.|||.                    .|:...|.:|.
Human   602 LVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETL 666

  Fly   674 HDESGIDTHSVSSYLSRSDSEKSM----EHQHNQLLRP------------------------DEH 710
            |..|......||...::..|.|..    |.:.|.:|.|                        ||.
Human   667 HRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEP 731

  Fly   711 VE-------DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIV--------------------ISL 748
            :|       |..|.:..:..|.:......::|.....:|.::                    :||
Human   732 LERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSL 796

  Fly   749 FVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIA----NDTLP-INATDPYI----- 803
              ..:..||.:|.: ||.:..|..:.::..   :||.|....    .:::| :...:.|:     
Human   797 --APQANLTELDIY-SRRLSQETGLEISEE---INEEDLKECFFDDMESIPAVTTWNTYLRYITV 855

  Fly   804 -----------APLLASDIQAGIRQELVLF--------------------YATILGATLIVYL-- 835
                       ..:..:::.|.:   :||:                    ||.|:.:|...|:  
Human   856 HKSLIFVLIWCLVIFLAEVAASL---VVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFY 917

  Fly   836 --------IRTFGFFK------MCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRT 886
                    :...|||:      ..:.:|..||.::...:.:|.|...||..:|.|||||||||..
Human   918 IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAI 982

  Fly   887 VDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESIS 951
            :|..||.|:.|.:..::.|.|.:.:||:...::.:....:.|...|:|..::.||:.:|:|||..
Human   983 LDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEG 1047

  Fly   952 RSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMT 1016
            |||:|:....:.:||.|:||...|...|..||:..|.:|:.|||:||..|.|.:..:::.:::..
Human  1048 RSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFI 1112

  Fly  1017 AVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEA--- 1078
            ||||..:|...| ..|.||:.:..:..:....||.:..:.::::.|.||.||.::.:.|:|.   
Human  1113 AVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPT 1176

  Fly  1079 ---------------LLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKI 1128
                           ::|. ...|....|||.|::...:...:|:.....:|::::|:|.|.:::
Human  1177 KSTKPYKNGQLSKVMIIEN-SHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRV 1240

  Fly  1129 GIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLD 1193
            |::||||:|||:::.:..||...||.|:||.|..:.|.|...|....:|||...:||||.|.|||
Human  1241 GLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD 1305

  Fly  1194 PMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMD 1258
            |.::.||:|:||...:|.|||.:....|.|:..:.|||...|.|.:||:||||::|...|||::|
Human  1306 PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLD 1370

  Fly  1259 EATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323
            |.:|::||.|.::|::|::..||.|||:...||:..:::..:.||::..:||:.....:||... 
Human  1371 EPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNER- 1434

  Fly  1324 GYLRQLVDNTGAATSFALQQAAEQSYSKQI--LGDDTAAE 1361
            ...||.:..:.....|..:.:::.....||  |.::|..|
Human  1435 SLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEE 1474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 409/1513 (27%)
ABC_membrane 94..360 CDD:294371 74/268 (28%)
ABCC_MRP_domain1 448..650 CDD:213217 88/230 (38%)
ABC_membrane 821..1046 CDD:294371 75/260 (29%)
ABCC_MRP_domain2 1096..1315 CDD:213211 82/218 (38%)
CFTRNP_000483.3 CFTR_protein 1..1480 CDD:273530 414/1535 (27%)
ABC_membrane 85..303 CDD:279056 66/221 (30%)
ABCC_CFTR1 389..670 CDD:213258 97/280 (35%)
CFTR_R 639..849 CDD:291094 33/215 (15%)
Disordered R region. /evidence=ECO:0000269|PubMed:10792060 654..831 32/182 (18%)
ABC_membrane 866..1147 CDD:279056 79/284 (28%)
ABCC_CFTR2 1208..1480 CDD:213256 92/268 (34%)
Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936 1386..1480 22/90 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1480 5/23 (22%)
PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976 1478..1480
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151598
Domainoid 1 1.000 62 1.000 Domainoid score I10331
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.850

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