DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC4

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1373	Identity:	546/1373 - (39%)
Similarity:	809/1373 - (58%)	Gaps:	114/1373 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDELKRS 73
            |:| ||...||..|:..|||:..|||.|.:..|.::::|.......|:.:..:....|:.|:.|:
Human     8 VKP-NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    74 -----NPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFAT--NQTDISENTAY 131
                 .||:.|.|::.|.|.::.:|: |::.|...|.:.|:|||.::.||..  ....::.||||
Human    72 ENDAQKPSLTRAIIKCYWKSYLVLGI-FTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135

  Fly   132 LYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSN 196
            .||..:..|.|:..|..|.:.:::...|.:||:|:..:||||.|::|..:......|:.:|:|||
Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200

  Fly   197 DLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMT 261
            |:.:||....|||..|.||:::|.:..|::.|||||.:.|::.::..:|||:...|..:..|..|
Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265

  Fly   262 AERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEV-KAIRGTAYIHAALGCTSMISPL 325
            |..||.|::.|||:|.||::||||||||||:.:|..:|.||: |.:|.:......|......|.:
Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKI 330

  Fly   326 SVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDK 390
            .||:...:||.||..:||.:|:...:.:..:..::..|:|.:|..::||:||.:|.:.|||
Human   331 IVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLL---- 391

  Fly   391 AEVPINLEANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSA 455
                  |:          :||::::|        |.|:|               ||.|.:::.:|
Human   392 ------LD----------EISQRNRQ--------LPSDG---------------KKMVHVQDFTA 417

  Fly   456 SWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQ 520
            .||.:.  ....::..|..::...|.||||||||||||.|:.:|||:....|...|||:|:|.||
Human   418 FWDKAS--ETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ 480

  Fly   521 ESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSL 585
            :.|||.||:|.||:|.:.|.:.||:||:|.|.|::|::||..|||||:|:||.:|||||||||:|
Human   481 QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNL 545

  Fly   586 ARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGK 650
            |||||:.||||||||||||||..|.:|:|:.||...|..||.||||||:|||.....:|::..||
Human   546 ARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGK 610

  Fly   651 IMAQGSYQELQRSR-QFQFLEQTQHDES------GIDTHSVSSYLSRSDSEKSMEHQHNQLLRP- 707
            ::.:|:|.|..:|. .|..|.:..::||      |..|     ..:|:.||.|:..|  |..||
Human   611 MVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPT-----LRNRTFSESSVWSQ--QSSRPS 668

  Fly   708 -------DEHVEDV----NQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDY 761
                   .:..|:|    ::|.::.|.:....|.:|.:|.....:...:|.|...|::.....|:
Human   669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733

  Fly   762 FLSRWVIWEEQIAVNRTTTLLNETDTTIANDT--LPINATDPYIAPLLASDIQAGIRQELVLFYA 824
            :||.|.         ...::||.|.....|.|  |.:|......:.|..:.:..||.:.|::||.
Human   734 WLSYWA---------NKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYV 789

  Fly   825 TILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDT 889
            .:                    ..|..||:::|..|.:|.:.||:.|..|||||||||||..:|.
Human   790 LV--------------------NSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDD 834

  Fly   890 DLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSP 954
            .||.|.||.:..::.|.|||.:......|:.||...:|:|...:|..::.|||.||||||.:|||
Human   835 LLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSP 899

  Fly   955 VFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVT 1019
            |||..:.:.|||.||||.:|:...::.|..:|:.::.||||||:.:|.||:..|.:|.:::..|.
Human   900 VFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVA 964

  Fly  1020 FSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPE 1084
            |..|:|....|:|.||||:.::.|:.||.||.:||:||:||.|.|||||:|||:...||..|..:
Human   965 FGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK 1029

  Fly  1085 KFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA 1149
              :|...||.:|.|.|.|....|||....|||.|...|:.:||:||||||||||||:|.::|||:
Human  1030 --RPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLS 1092

  Fly  1150 CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRS 1214
            ..||.|.||.:....|||||||.::|||||:||||:||:|.||||.:|.:|||:|.||.:|:|:.
Human  1093 EPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKE 1157

  Fly  1215 YVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSK 1279
            .:..|.|.::..:.:.||||||||||||||||||||.|:|||:|||||||||.||:|||:.||.|
Human  1158 TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREK 1222

  Fly  1280 FAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQA 1344
            |||||||||||||:|::|||:::|:|:|.::|...||.|||.......::|...|.|.:.||.:.
Human  1223 FAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTET 1287

  Fly  1345 AEQSYSKQ 1352
            |:|.|.|:
Human  1288 AKQVYFKR 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	540/1359 (40%)
		ABC_membrane	94..360	CDD:294371	94/268 (35%)
		ABCC_MRP_domain1	448..650	CDD:213217	105/201 (52%)
		ABC_membrane	821..1046	CDD:294371	85/224 (38%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	131/218 (60%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	535/1341 (40%)
		ABC_membrane	96..365	CDD:294371	95/269 (35%)
		ABCC_MRP_domain1	410..610	CDD:213217	105/201 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		7/32 (22%)
		ABC_membrane	718..991	CDD:279056	103/301 (34%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	131/218 (60%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151555
Domainoid	1	1.000	101	1.000	Domainoid score	I6950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860