DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and abcc8

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_031756190.1	Gene:	abcc8 / 101730668	-ID:	-	Length:	1580	Species:	Xenopus tropicalis

Alignment Length:	1472	Identity:	423/1472 - (28%)
Similarity:	698/1472 - (47%)	Gaps:	260/1472 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLD----------SERVTNKFA 63
            ||...||  .|..|:.::|||....|..            |:|.:|          ...|||...
Frog   215 VRFLQPF--VNLLSKGTYWWMNTFIKTA------------HKKPIDLKAIGKLPIAMRAVTNYLL 265

  Fly    64 --ELWEDELKRSNP------SVVRMILRAYGK------IFVPMGLAFSISETICKS--------- 105
              :.:..:..:|:|      |:...:.:|:|:      ||..|......:..:|.|
Frog   266 LNKAFHSQKSKSSPCPAGPKSIWFALCQAFGRPLILSSIFRIMADMLGFAGPLCISGIVHHLSQE 330

  Fly   106 -----LMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLA 165
                 ..|:|||   .:|.::|..::  .||:.|:.:...:|:.........:...:.|..||.|
Frog   331 NKTFHPQPIFLG---VFFISSQEFLA--NAYVLAVLLFFALLLQRSFLQASYYVAIETGINLRGA 390

  Fly   166 LSGLIYRKVLQVSKSSSNDG--LRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYRE 228
            :...||.|::.:|.|:.:.|  ..|:..|:::.|..:.........:.|..|::.|:...|:|..
Frog   391 IQTKIYNKIMHLSTSNMSMGEMSSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYI 455

  Fly   229 IGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFAR 293
            :||||:||...::...|:|.:.|.|.:..::.|.|.::.|:|..||:::||:::|:|:||..|..
Frog   456 LGISALIGAVVIIVLAPIQYFVATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSWEHIFHS 520

  Fly   294 VIAEVRLKEVKAIRGTA-------YIHAALGCTSMI---------------SPLSVFLALCSYVY 336
            .:.|.|.||:.:::..|       :::||:...:::               ||...|.:|..:..
Frog   521 SVEETRQKEMNSLKAFALYTSISIFMNAAIPIAAVLITFVVHVHLLHREQFSPAVAFASLSLFHI 585

  Fly   337 LGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLE--- 398
            |..||     :.:||.               :....:||||.::..:|.   ...|:...:|
Frog   586 LVTPL-----FLLSSV---------------VRSTVKALVSVQKLSEFF---SSEEIGEEVEKCP 627

  Fly   399 -ANQQTGKNK-----RKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDP---EATKKCVVLKNVS 454
             :|:...:||     .|:..:.:....:.|         |.|..:...|   |..:.|:.:.:..
Frog   628 PSNKSVPQNKYQAVPLKVVNRKRPIRDDWN---------HFNSRQRGAPNPTEGNEFCIKVTSGF 683

  Fly   455 ASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGE------------------ 501
            .:| |.||..  |:......|....|..:||.||.||||.|...|||
Frog   684 FTW-TPDGPP--ALSSIDIRIPQGQLTMIVGQVGCGKSSLLLATLGEMHKISGDVSWNSTVPDSE 745

  Fly   502 ----VGIDKG-----EAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDM 557
                |..||.     |....|.::||||:.|:...|:.:||.|...:|:::||.::..|.|:.|:
Frog   746 TGEDVNPDKETAIDVETRRRGAVAYASQKPWLLNATVEENITFESPFNKQKYKAIIDACSLQPDI 810

  Fly   558 ELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFL 622
            ::||.||.|.:||||::|||||:.|:|:||.:|::..:..||||.||:|.|:..|:....|...|
Frog   811 DILPHGDQTQIGERGINLSGGQRQRISVARVLYQQTSVVFLDDPFSALDIHLSDHLMHEGILKML 875

  Fly   623 SNKIR--ILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRS-------------RQFQFLEQT 672
            .:..|  :||||::|||...:.::.|..|.|..:|:.:::|:|             ||.|.||:
Frog   876 RDNKRTTVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDIQKSDPELYEHWKTLMNRQDQELEK- 939

  Fly   673 QHDESGIDTHSVSSYLSRSDSEKSME-----HQHNQLLRPD----EHVEDVNQEQQTVGSIKMHV 728
                        ...|.|....:.|.     :..:.||..|    |.:.:..::...:.|: :|.
Frog   940 ------------EIILDRKAGGERMNLTRTIYPRDALLGDDEEDEEEISESEEDDDNLSSV-LHQ 991

  Fly   729 YASYI-----KALDSTFLLGIVISLFVCARIM----LTGVDYFLSRWVIWEEQIAVNRTTTLLNE 784
            .|...     |.|.|..:|  ::.|.|.::::    :..:|::|::|           |:..:
Frog   992 RAKMPWRACGKYLSSAGIL--LLPLLVLSQLLKHSVMVAIDFWLAKW-----------TSAAI-- 1041

  Fly   785 TDTTIAN-DTLPINATD--PYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCL 846
            |:.::|| ...|....|  ||                 .:.::.:....:|:.|..:.......|
Frog  1042 TNLSVANCSGRPTCRFDHSPY-----------------SMAFSILSCVGIIMCLATSIAVEWTGL 1089

  Fly   847 RISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCL--AFIIDVSGVV 909
            |::..||..|...|..|.|.||.|...|.||||||.|..|:|..:|.| |:||  :.::.||.:.
Frog  1090 RVAKKLHSSLLNAIILAPMRFFETTPLGSILNRFSADFNTIDQHIPAT-LECLSRSTLLCVSALA 1153

  Fly   910 IIVAIANYWL--LIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRAL 972
            :|..:...:|  |:|.|||...:.  :|..| .||.:::||..::.|:.|...:|.:|||||||.
Frog  1154 VISYVTPVFLISLVPLAIICYFIQ--KYFRV-ASRDLQQLEDSTQLPLLSHFAETVEGLTTIRAF 1215

  Fly   973 QAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV------LCIVYMTAVTFSFLLLKDEFDS 1031
            :.:....|:..|:.::|..| .|||:....   |.:|      .|:|.:.||......|.....|
Frog  1216 RYEPRFRQKLLEHTDSNNIA-SLFLTAANR---WLEVRMEYIGACVVLIAAVASITNSLHYNLSS 1276

  Fly  1032 GDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERV--LEYTEQPSEALLETPEKFKPKSEWPS 1094
            |.|||.:.::..::....|.:|..:::|.|:.:|:|:  |..||..:...|.:|.:..|  .||.
Frog  1277 GLVGLGLTYALMVSNYLNWMVRNLSDMEIQLGAVKRINGLLKTEPENYKGLLSPTQIPP--NWPE 1339

  Fly  1095 KGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACN-EGMIRID 1158
            .|.|:..|..:||.....||||.:|..|.|.:||||.||||:||||...:.||:... :|.|.||
Frog  1340 NGEIQIQNLSVRYDSSLKPVLKHVNAHITPGQKIGICGRTGSGKSSFSLAFFRMVDTFQGRIIID 1404

  Fly  1159 DVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGL 1223
            .:||..:.|..|||::|||.|||:|||||:|:||||.::.:|..:|:||...:|:..|..|.|||
Frog  1405 GIDIAKLPLQTLRSRLSIILQDPILFSGTIRFNLDPENKCTDAMLWEALEIAQLKHVVKVLPGGL 1469

  Fly  1224 NCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTI 1288
            :..:.:||.|||||||||.|||||.:|.:.|||||||||::|..|:.::|:.:.:.|...||:||
Frog  1470 DALVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFDDRTVVTI 1534

  Fly  1289 AHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLV 1330
            |||:||::::|.|:||..|.:.|...|..||:..|......|
Frog  1535 AHRVHTILNADLVIVMKRGAIMEYDKPEALLEGGGSMFASYV 1576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	421/1469 (29%)
		ABC_membrane	94..360	CDD:294371	69/303 (23%)
		ABCC_MRP_domain1	448..650	CDD:213217	78/230 (34%)
		ABC_membrane	821..1046	CDD:294371	72/234 (31%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	107/219 (49%)
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	417/1456 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010