DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC9

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001364202.1	Gene:	ABCC9 / 10060	HGNCID:	60	Length:	1549	Species:	Homo sapiens

Alignment Length:	1432	Identity:	425/1432 - (29%)
Similarity:	713/1432 - (49%)	Gaps:	209/1432 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRPKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLD----------SERVTNK-- 61
            ||...||  .|..|:.::|||..|.            :..|:|.:|          ...|||.
Human   213 VRFLQPF--VNLLSKATYWWMNTLI------------ISAHKKPIDLKAIGKLPIAMRAVTNYVC 263

  Fly    62 FAELWEDELKR------SNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYF-- 118
            ..:.:|::.|:      ..||:...:.||:|:..: :...|.....:.....||.:.|:|...
Human   264 LKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPIL-LSSTFRYLADLLGFAGPLCISGIVQRVNE 327

  Fly   119 ----ATNQTDISE--------NTAYLYAMGIVICMLVPVITFHPFIFYI-FQVGTKLRLALSGLI 170
                ..|.|.|||        ..||:.|: ::...|:...||....:|: .:.|..||.||..:|
Human   328 TQNGTNNTTGISETLSSKEFLENAYVLAV-LLFLALILQRTFLQASYYVTIETGINLRGALLAMI 391

  Fly   171 YRKVLQVSKSSSNDG--LRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGISA 233
            |.|:|::|.|:.:.|  ..|:..|:::.:..:....|....:.|..|::.|:...|:|..:|.||
Human   392 YNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSA 456

  Fly   234 VIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEV 298
            ::|.:.::...|:|.:.|.|.|..::.|.:.:..|:|..|||::||:::|:||||..|.:.:.|.
Human   457 LVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET 521

  Fly   299 RLKEVKAIRGTA-YIHAALGCTSMISPLSVFLALCSYVYL-GDPLTAQKVYTVSSYFNMLNDSMV 361
            |:||:.:::..| |...::...:.|...:|.....::.|. |:.|...:.:...|.|::|   :.
Human   522 RMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL---VT 583

  Fly   362 TFWPMS--ITFIAEALVSAKRCKDFLLD---GD------KAEVPINLEANQQTGKNKRKISKKDK 415
            ..:.:|  :.|..:|::|.::..:|||.   ||      ::.:|.. ...:.||...:.|::|..
Human   584 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFE-SCKKHTGVQPKTINRKQP 647

  Fly   416 QKNVELNGSLLSNGQVH-------HNRLRDYDPEATKKCVV-LKNVSASWDTSDGHANCAIEDFS 472
                         |:.|       ..|||   |..|:...: :.|...||    |.....:.:..
Human   648 -------------GRYHLDSYEQSTRRLR---PAETEDIAIKVTNGYFSW----GSGLATLSNID 692

  Fly   473 TDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHG-------------------KISYA 518
            ..|....|..:||.||.||||.|..:|||:...:|:  ||.                   .::||
Human   693 IRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGK--VHWSNVNESEPSFEATRSRNRYSVAYA 755

  Fly   519 SQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARV 583
            :|:.|:...|:.:||.|...:|::|||.|...|.|:.|::|||.||.|.:||||::|||||:.|:
Human   756 AQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 820

  Fly   584 SLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIR--ILVTHQVQYLFDVEHLLLM 646
            .:|||:|:..:|..||||.||:|.|:..|:....|..||.:..|  :||||::|||...:.::.|
Human   821 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAM 885

  Fly   647 GSGKIMAQGSYQELQ-------------RSRQFQFLEQ-TQHDESGIDTHSVSSYLSRSDSEKSM 697
            ..|.::.:|:.:::|             .:||.|.||: .:.|::.::..::...:...:::..|
Human   886 KDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQM 950

  Fly   698 EHQHNQLLRPDEHVEDVNQEQQTVGSIKMHV-YASYIKALDS--TFLLGIVISLFVCARIMLTGV 759
            |.:..:    :|..||.:....||..::..: :.:..:.|.|  .|||.::|...:....::..:
Human   951 EDEDEE----EEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI 1011

  Fly   760 DYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYA 824
            ||:|:.|.   .:.::|.|    .:.|.|.            |:|.                 ::
Human  1012 DYWLATWT---SEYSINNT----GKADQTY------------YVAG-----------------FS 1040

  Fly   825 TILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDT 889
            .:.||.:.:.|:.:.....|.|..:.:||..|...|....:.||:|...|.||||||.|...:|.
Human  1041 ILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ 1105

  Fly   890 DLPHTL-------LDCLAFI--IDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVK 945
            .:|.||       |.||:.|  |..:..|.:||      |:|   :||....|:..:...|:.::
Human  1106 HIPPTLESLTRSTLLCLSAIGMISYATPVFLVA------LLP---LGVAFYFIQKYFRVASKDLQ 1161

  Fly   946 RLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDV- 1009
            .|:..::.|:....::|.:|||||||.:.::..:|...|..:||..| :||||....   |.:|
Human  1162 ELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA-YLFLSAANR---WLEVR 1222

  Fly  1010 -----LCIVYMTAVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVL 1069
                 .|||    :|.|...:....:||.|||.:|::.|:|....|.:|..|:||.||.:|::|.
Human  1223 TDYLGACIV----LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVN 1283

  Fly  1070 EYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRT 1134
            .:....||....|.:..:....||.:|.|:..:..:||.....||||.:...|:|.:|:||.|||
Human  1284 SFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRT 1348

  Fly  1135 GAGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDER 1198
            |:||||:..:.||:. ..:|.|.||.:||..:.||.|||::|||.|||:||||::|:||||..:.
Human  1349 GSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKC 1413

  Fly  1199 SDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATAN 1263
            :|:.:|:||...:|::.|.:|.|||:..:.:||.|||||||||.|||||.:|.:.|||||||||:
Human  1414 TDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATAS 1478

  Fly  1264 VDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQ 1328
            :|..|:.::|:.:.:.||..||:|||||:||::.:|.|:||..|.:.|...|..||.:..|....
Human  1479 IDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFAS 1543

  Fly  1329 LV 1330
            .|
Human  1544 FV 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	423/1429 (30%)
		ABC_membrane	94..360	CDD:294371	74/284 (26%)
		ABCC_MRP_domain1	448..650	CDD:213217	79/223 (35%)
		ABC_membrane	821..1046	CDD:294371	71/239 (30%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	105/219 (48%)
ABCC9	NP_001364202.1	MRP_assoc_pro	222..1546	CDD:188098	420/1421 (30%)
ABCC9	NP_001364202.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..967		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650