DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC5

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	1426	Identity:	476/1426 - (33%)
Similarity:	738/1426 - (51%)	Gaps:	172/1426 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKVVRPKNPFTKANFFSQWSFWWMRDLFK-RGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDE 69
            |...:.::|...|..||..:|.|:..|.: ...:|.|:.|:::...|...|:....:...||::|
Human    92 RTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE 156

  Fly    70 LKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVG----------YFATNQTD 124
            |....|....  ||....||....|..||   :|  ||...|.|..|          |  |..|:
Human   157 LNEVGPDAAS--LRRVVWIFCRTRLILSI---VC--LMITQLAGFSGPAFMVKHLLEY--TQATE 212

  Fly   125 ISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGR 189
            .:...:.|..:|:::..:|...:........::.|.:||.|:..:.::|:|:: |:.....| |.
Human   213 SNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL-KNIKEKSL-GE 275

  Fly   190 AINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREI--GISAVIGVSFMLSFIPLQAWAAK 252
            .|||.|||..|...|.........||:.:||  .::|..|  |.:..:|.:..:.|.|...:|::
Human   276 LINICSNDGQRMFEAAAVGSLLAGGPVVAIL--GMIYNVIILGPTGFLGSAVFILFYPAMMFASR 338

  Fly   253 KAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALG 317
            ..||:|:.....||.||:.|||::..|:.||||||.|:|::.:.::|.:|.:.:....|..:
Human   339 LTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQS--- 400

  Fly   318 CTSMISPLSVFLA----LCSYVYLGDPLTAQKVYTVSSYFNMLNDSM-VTFWPMSITFIAEALVS 377
            .|..::|:.|.:|    ...::.||..|||.:.:||.:.||.:..:: ||  |.|:..::||.|:
Human   401 ITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT--PFSVKSLSEASVA 463

  Fly   378 AKRCKD-FLLD------GDKAEVPINLEANQQT--------------------GKNKR-KISKKD 414
            ..|.|. ||::      ...|...|.:|....|                    .|:|| ...||:
Human   464 VDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKE 528

  Fly   415 KQKNVEL--NGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANC--AIEDFSTDI 475
            |.:.::.  :.::|:..:.|  .|.|.|...:.:....|::..      ||...  .:.....:|
Human   529 KVRQLQRTEHQAVLAEQKGH--LLLDSDERPSPEEEEGKHIHL------GHLRLQRTLHSIDLEI 585

  Fly   476 KDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYN 540
            ::..|..:.|.||:||:|.::.:||::.:.:|...:.|..:|.:|::|:...|:||||:|.::|:
Human   586 QEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYD 650

  Fly   541 ERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAV 605
            |.||..|:..|.|..|:.:||..|||.:||||.:|||||:.|:|||||:|....||:|||||||:
Human   651 EERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSAL 715

  Fly   606 DTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQ--------- 661
            |.|||.|||:..||..|.:|..:.||||:|||.|.:.::.|..|.|..:|:::||.
Human   716 DAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI 780

  Fly   662 --------------RSRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVE 712
                          .|::.....|.:..:.|..|.||.       .||:::.:..||
Human   781 FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVK-------KEKAVKPEEGQL-------- 830

  Fly   713 DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWV-IWEEQIAVN 776
             |..|::..||:...||..||:|........::::||    ::..|...|.:.|: .|.:|.:.|
Human   831 -VQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALF----MLNVGSTAFSTWWLSYWIKQGSGN 890

  Fly   777 RTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGF 841
            .|.|..|||.   .:|::..|....|.|.:                ||..:...||:..||...|
Human   891 TTVTRGNETS---VSDSMKDNPHMQYYASI----------------YALSMAVMLILKAIRGVVF 936

  Fly   842 FKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVS 906
            .|..||.|..|||.|||.|.|:.|.||:|..:||||||||||:..||..||......:..:|.|.
Human   937 VKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVF 1001

  Fly   907 GVVIIVAIANYWLLI---PAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTT 968
            ..|.::|....|.|:   |..|:..:|.::..:.:   |.:|||::|::||..|....:.|||.|
Human  1002 FCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLAT 1063

  Fly   969 IRALQAQSALEQEF-HEYQ---NTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEF 1029
            |.|...    .||| |.||   :.|.:.:|||....|..|:..|::.|..:|......:|:..:.
Human  1064 IHAYNK----GQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQI 1124

  Fly  1030 DSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFK---PKSE 1091
            .....||||.::..:||:.|:.:|..:|.|.:.|||||:..|.:..|   ||.|.:.|   |..:
Human  1125 PPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS---LEAPARIKNKAPSPD 1186

  Fly  1092 WPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA-CNEGMI 1155
            ||.:|.:.|.|.::||......|||.::|||:|:||||||||||:||||:..::|||. .:.|.|
Human  1187 WPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCI 1251

  Fly  1156 RIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLI 1220
            :||.|.|..|||.||||::|||||:|||||||:|.||||.::.:::::|.||....::..::.|.
Human  1252 KIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316

  Fly  1221 GGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTV 1285
            ..|...:.:.|.|||||:|||:|:|||:|||.||||:|||||.:|.|||.|||:|||..||.||:
Human  1317 LKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTM 1381

  Fly  1286 LTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAAE 1346
            ||||||||||:.|||::|:..|:|.|...|..||            :..::..:|:..|||
Human  1382 LTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL------------SNDSSRFYAMFAAAE 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	472/1415 (33%)
		ABC_membrane	94..360	CDD:294371	78/281 (28%)
		ABCC_MRP_domain1	448..650	CDD:213217	82/203 (40%)
		ABC_membrane	821..1046	CDD:294371	80/231 (35%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	120/219 (55%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	473/1416 (33%)
		ABC_membrane	<271..447	CDD:294371	56/181 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538		6/36 (17%)
		ABCC_MRP_domain1	577..759	CDD:213217	79/181 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		8/39 (21%)
		ABC_membrane	863..1143	CDD:294371	99/309 (32%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	120/219 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.610